The Arizona Diamondbacks have the most runs by a team in a loss this season, with 12 runs versus the Rockies on May 17.

Interpreted as:

MLB most runs in a regular-season loss in MLB this season

	TEAM	R	L	DATE	TM		OPP	RESULT	W	L%	AB	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Diamondbacks	12	1	5/17/2025	AZ	vs	COL	L 12-14	0	1.000	43	15	5	1	2	10	4	1	7	2	0	49	28	8	0	1	0	0	.349	.408	.651	1.059
2	Diamondbacks	11	1	5/9/2025	AZ	vs	LAD	L 11-14	0	1.000	38	11	2	0	5	11	6	1	6	0	0	45	28	7	0	0	1	0	.289	.400	.737	1.137
3	Rockies	11	1	4/19/2025	COL	vs	WSH	L 11-12	0	1.000	35	8	0	3	1	11	6	2	17	1	0	44	17	4	0	1	0	0	.229	.364	.486	.849
4	Diamondbacks	11	1	4/18/2025	AZ	@	CHC	L 11-13	0	1.000	43	15	4	0	2	11	3	0	9	0	0	46	25	6	0	0	0	0	.349	.391	.581	.973
5	Rays	10	1	6/7/2025	TBR	vs	MIA	L 10-11	0	1.000	39	9	3	0	5	10	2	1	8	0	0	43	27	8	1	0	0	0	.231	.286	.692	.978
6	Braves	10	1	6/5/2025	ATL	vs	AZ	L 10-11	0	1.000	37	13	5	0	3	10	4	0	9	0	1	41	27	8	0	0	0	2	.351	.415	.730	1.144
7	Dodgers	10	1	4/22/2025	LAD	@	CHC	L 10-11	0	1.000	39	10	3	0	3	10	4	0	10	0	0	44	22	6	0	1	0	1	.256	.318	.564	.882
8	Marlins	10	1	4/19/2025	MIA	@	PHI	L 10-11	0	1.000	42	15	4	0	2	10	3	1	2	0	0	46	25	6	0	0	0	1	.357	.413	.595	1.008
9	Nationals	9	1	6/13/2025	WSH	vs	MIA	L 9-11	0	1.000	43	16	1	0	1	9	2	1	11	0	0	46	20	2	0	0	0	0	.372	.413	.465	.878
10	Cardinals	9	1	6/10/2025	STL	vs	TOR	L 9-10	0	1.000	38	12	0	0	3	9	2	1	4	0	0	41	21	3	0	0	0	1	.316	.366	.553	.918
11	Angels	9	1	6/4/2025	LAA	@	BOS	L 9-11	0	1.000	37	12	5	1	1	9	4	0	8	0	0	42	22	7	0	1	0	1	.324	.381	.595	.976
12	Dodgers	9	1	5/17/2025	LAD	vs	LAA	L 9-11	0	1.000	41	15	1	0	2	7	5	1	7	1	0	47	22	3	0	0	0	1	.366	.447	.537	.983
13	Red Sox	9	1	5/13/2025	BOS	@	DET	L 9-10	0	1.000	47	14	3	0	3	9	2	1	15	0	0	50	26	6	0	0	0	0	.298	.340	.553	.893
14	Blue Jays	9	1	5/13/2025	TOR	vs	TBR	L 9-11	0	1.000	36	10	5	0	4	9	5	0	11	1	0	41	27	9	0	0	0	1	.278	.366	.750	1.116
15	Astros	9	1	5/10/2025	HOU	vs	CIN	L 9-13	0	1.000	40	14	3	1	1	9	7	0	10	1	0	47	22	5	0	0	0	1	.350	.447	.550	.997
16	Rockies	9	1	5/9/2025	COL	vs	SDP	L 9-13	0	1.000	41	15	4	0	3	9	2	0	6	0	0	44	28	7	0	1	0	1	.366	.386	.683	1.069
17	Guardians	9	1	5/6/2025	CLE	@	WSH	L 9-10	0	1.000	39	14	2	0	1	8	4	0	1	2	0	44	19	3	0	1	0	0	.359	.409	.487	.896
18	Phillies	9	1	5/4/2025	PHI	vs	AZ	L 9-11	0	1.000	42	14	2	0	3	9	5	0	14	0	0	48	25	5	0	1	0	1	.333	.396	.595	.991
19	Cardinals	9	1	4/4/2025	STL	@	BOS	L 9-13	0	1.000	40	14	2	0	2	8	2	0	9	1	0	42	22	4	0	0	0	3	.350	.381	.550	.931
20	Mariners	9	1	4/4/2025	SEA	@	SFG	L 9-10	0	1.000	48	15	0	0	2	6	7	0	8	3	0	56	21	2	1	0	1	0	.313	.400	.438	.838
21	Brewers	9	1	3/29/2025	MIL	@	NYY	L 9-20	0	1.000	44	13	2	0	1	7	2	2	9	1	0	48	18	3	0	0	0	0	.295	.354	.409	.763
22	Tigers	8	1	6/20/2025	DET	@	TBR	L 8-14	0	1.000	34	8	1	0	3	8	4	0	9	0	0	39	18	4	0	1	0	0	.235	.308	.529	.837
23	Rockies	8	1	6/20/2025	COL	vs	AZ	L 8-14	0	1.000	38	12	4	0	2	8	1	0	12	0	0	40	22	6	0	1	0	0	.316	.325	.579	.904
24	Orioles	8	1	6/18/2025	BAL	@	TBR	L 8-12	0	1.000	35	7	1	0	3	8	1	1	7	1	0	37	17	4	0	0	0	0	.200	.243	.486	.729
25	Red Sox	8	1	6/9/2025	BOS	vs	TBR	L 8-10	0	1.000	43	10	4	0	0	6	8	2	12	2	0	53	14	4	0	0	1	1	.233	.377	.326	.703