The Philadelphia Phillies have put up the most runs by a team in a loss, with 23 runs versus the Cubs on August 25, 1922.

Interpreted as:

MLB most runs in a regular-season loss in MLB history

	TEAM	R	L	DATE	TM		OPP	RESULT	W	L%	AB	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Phillies	23	1	8/25/1922	PHN	@	CHC	L 23-26	0	1.000	52	26	4	2	0	19	11	0	5	1	1	66	34	6	3				.500	.587	.654	1.241
2	Cubs	22	1	5/17/1979	CHC	vs	PHI	L 22-23	0	1.000	56	26	3	1	6	22	3	0	4	0	0	59	49	10	0	0	0	2	.464	.492	.875	1.367
3	Stars	21	1	4/18/1890	SYR	@	BKA	L 21-22	0	1.000
4	Orioles	19	1	6/17/1891	BAL	@	WSH	L 19-20	0	1.000
5	Colonels	19	1	6/6/1888	LOU	@	CLE	L 19-23	0	1.000
6	Rangers	17	1	8/12/2008	TEX	@	BOS	L 17-19	0	1.000	47	20	7	0	1	17	3	1	6	0	0	53	30	8	0	2	0	0	.426	.453	.638	1.091
7	Marlins	17	1	7/4/2008	FLA	@	COL	L 17-18	0	1.000	47	22	7	0	2	17	6	2	4	0	0	56	35	9	1	0	1	1	.468	.545	.745	1.290
8	Phillies	17	1	8/3/1969	PHI	vs	CIN	L 17-19	0	1.000	47	21	4	1	3	17	4	0	6	1	0	51	36	8	0	0	1	2	.447	.490	.766	1.256
9	Indians	17	1	7/10/1932	CLE	vs	PHA	L 17-18	0	1.000	83	33	9	0	1	16	10	0	7	1	0	95	45	10	2				.398	.462	.542	1.005
10	Beaneaters	17	1	4/19/1900	BSN	vs	PHI	L 17-19	0	1.000
11	Alleghenys	17	1	8/7/1890	PTN	@	CIN	L 17-23	0	1.000
12	Giants	17	1	5/23/1889	NYG	vs	CWS	L 17-18	0	1.000
13	Wolverines	17	1	7/28/1888	DET	@	CWS	L 17-21	0	1.000
14	Metropolitans	17	1	4/26/1887	NYM	@	PHA	L 17-18	0	1.000
15	White Stockings	17	1	8/14/1883	CWS	@	BUF	L 17-19	0	1.000
16	Colonels	17	1	7/6/1882	LOU	@	STL	L 17-21	0	1.000
17	Athletics	16	1	5/5/2000	OAK	@	TEX	L 16-17	0	1.000	43	16	3	0	5	16	8	0	8	0	1	51	34	8	0	0	0	0	.372	.471	.791	1.261
18	Tigers	16	1	9/14/1998	DET	vs	CWS	L 16-17	0	1.000	58	22	4	1	3	16	1	0	10	1	0	60	37	8	0	1	1	0	.379	.383	.638	1.021
19	Cubs	16	1	4/17/1976	CHC	vs	PHI	L 16-18	0	1.000	48	19	5	0	3	16	6	3	7	0	0	58	33	8	1	0	1	1	.396	.491	.688	1.179
20	Giants	16	1	5/23/1970	SFG	vs	SDP	L 16-17	0	1.000	60	23	2	0	4	16	10	0	12	1	2	76	37	6	6	0	3	1	.383	.471	.617	1.088
21	Phillies	16	1	9/23/1930	PHN	vs	SLN	L 16-19	0	1.000	44	16	4	0	1	13	6	0	7	0	0	50	23	5	0				.364	.440	.523	.963
22	Phillies	16	1	5/18/1929	PHN	vs	BKN	L 16-20	0	1.000	41	17	6	0	2	16	12	0	6	2	0	53	29	8	0				.415	.547	.707	1.254
23	Cardinals	16	1	6/2/1900	STL	@	BSN	L 16-17	0	1.000
24	Bridegrooms	16	1	9/23/1896	BKN	@	PHI	L 16-17	0	1.000
25	Senators	16	1	8/8/1896	WSH	vs	BAL	L 16-21	0	1.000