Between the 1920 and 1929 seasons, Burleigh Grimes won the most games, with 190 wins.

Interpreted as:

MLB most regular-season wins 1920s pitcher

	NAME	W	L	W%	G	GS	ERA	SO	CG	SHO	SV	IP	H	ER	R	HR	BB	HBP	GF	TBF	WP	K/9	BB/9	K/BB	HR/9	K%	BB%	WHIP	BABIP	RA	ERA-	FIP	FIP-	H/9	PRAA
1	Burleigh Grimes B. Grimes	190	130	.594	373	336	3.52	1,018	234	20	11	2797.2	2,988	1,093	1,354	105	842	62	31	12,039	51	3.27	2.71	1.21	0.34	8.5	7.0	1.37	.288	4.36	90	3.72	94	9.61	69.1
2	Eppa Rixey E. Rixey	166	142	.539	386	330	3.24	686	185	20	10	2678.1	2,827	964	1,169	59	567	37	47	11,150	38	2.31	1.91	1.21	0.20	6.2	5.1	1.27	.282	3.93	85	3.44	89	9.50	117.2
3	Grover Alexander G. Alexander	165	105	.611	325	290	3.04	653	194	20	16	2415.1	2,528	816	982	111	349	15	29	9,893	18	2.43	1.30	1.87	0.41	6.6	3.5	1.19	.276	3.66	77	3.48	88	9.42	127
4	Herb Pennock H. Pennock	163	112	.593	352	286	3.44	731	181	21	23	2313.0	2,485	883	1,038	87	556	21	48	9,743	28	2.84	2.16	1.31	0.34	7.5	5.7	1.31	.287	4.04	86	3.60	91	9.67	88.4
5	Waite Hoyt W. Hoyt	161	102	.612	379	280	3.51	748	160	17	30	2346.0	2,464	914	1,080	88	669	33	80	9,964	25	2.87	2.57	1.12	0.34	7.5	6.7	1.34	.282	4.14	87	3.75	94	9.45	57.6
6	Urban Shocker U. Shocker	156	93	.627	330	261	3.34	753	168	22	22	2148.2	2,256	797	946	117	484	26	53	9,020	10	3.15	2.03	1.56	0.49	8.3	5.4	1.28	.280	3.96	80	3.71	90	9.45	102.2
7	Eddie Rommel E. Rommel	154	108	.588	424	230	3.47	530	132	17	25	2243.1	2,367	865	1,054	116	652	31	138	9,531	25	2.13	2.62	0.81	0.47	5.6	6.8	1.35	.274	4.23	82	4.11	98	9.50	21.7
8	Jesse Haines J. Haines	153	119	.563	346	293	3.61	742	169	20	5	2328.1	2,490	935	1,132	122	644	47	32	9,897	33	2.87	2.49	1.15	0.47	7.5	6.5	1.35	.284	4.38	92	3.92	99	9.62	3.6
9	George Uhle G. Uhle	152	124	.551	356	285	3.97	808	182	16	16	2309.2	2,570	1,019	1,214	64	719	90	51	10,125	43	3.15	2.80	1.12	0.25	8.0	7.1	1.42	.297	4.73	95	3.72	90	10.01	112.1
10	Red Faber R. Faber	149	116	.562	316	297	3.34	804	181	17	4	2364.0	2,429	878	1,045	73	664	47	14	9,958	28	3.06	2.53	1.21	0.28	8.1	6.7	1.31	.281	3.98	83	3.62	90	9.25	101.7
11	Dazzy Vance D. Vance	147	90	.620	266	244	3.10	1,464	172	22	4	2053.2	1,891	708	820	83	583	61	18	8,506	24	6.42	2.55	2.51	0.36	17.2	6.9	1.20	.286	3.59	77	3.05	76	8.29	219.9
12	Bill Sherdel B. Sherdel	139	108	.563	378	209	3.70	657	128	10	24	2061.1	2,317	848	999	116	490	45	118	8,853	18	2.87	2.14	1.34	0.51	7.4	5.5	1.36	.292	4.36	93	3.86	97	10.12	28.7
13	Dolf Luque D. Luque	138	146	.486	353	302	3.09	904	168	21	8	2479.2	2,446	851	1,059	75	688	21	38	10,321	35	3.28	2.50	1.31	0.27	8.8	6.7	1.26	.275	3.84	82	3.52	93	8.88	74.3
14	Sad Sam Jones S. Sam Jones	137	118	.537	363	278	3.83	718	150	21	23	2230.0	2,345	948	1,137	85	791	36	59	9,559	37	2.90	3.19	0.91	0.34	7.5	8.3	1.41	.285	4.59	95	3.95	99	9.46	9.4
15	Howard Ehmke H. Ehmke	136	137	.498	333	275	3.81	824	162	14	13	2265.0	2,319	959	1,151	89	805	118	43	9,783	17	3.27	3.20	1.02	0.35	8.4	8.2	1.38	.281	4.57	93	3.99	98	9.21	23.1
16	Stan Coveleski S. Coveleski	133	89	.599	274	253	3.20	558	137	21	9	1933.2	2,041	688	851	53	510	18	16	8,171	21	2.60	2.37	1.09	0.25	6.8	6.2	1.32	.283	3.96	78	3.57	88	9.50	97.7
17	Jack Quinn J. Quinn	131	111	.541	368	251	3.50	575	124	19	22	2042.0	2,317	795	983	65	432	47	68	8,739	24	2.53	1.90	1.33	0.29	6.6	4.9	1.35	.296	4.33	85	3.54	86	10.21	126.3
18	Lee Meadows L. Meadows	128	103	.554	287	255	3.66	574	146	15	2	1946.1	2,130	792	973	65	524	48	19	8,317	30	2.65	2.42	1.10	0.30	6.9	6.3	1.36	.291	4.50	90	3.71	90	9.85	92.9
19	Tom Zachary T. Zachary	128	122	.512	336	263	3.74	426	126	15	11	2018.1	2,313	838	1,017	77	609	33	50	8,685	24	1.90	2.72	0.70	0.34	4.9	7.0	1.45	.297	4.53	93	4.01	101	10.31	-12.9
20	Pete Donohue P. Donohue	126	107	.541	308	248	3.68	532	132	16	12	1962.0	2,210	803	969	57	376	43	45	8,355	10	2.44	1.72	1.41	0.26	6.4	4.5	1.32	.293	4.44	95	3.49	90	10.14	81.2
21	Carl Mays C. Mays	126	72	.636	304	200	3.44	409	132	14	19	1796.1	1,898	686	812	62	407	40	77	7,512	13	2.05	2.04	1.00	0.31	5.4	5.4	1.28	.278	4.07	87	3.72	95	9.51	38.6
22	Art Nehf A. Nehf	123	77	.615	312	212	3.66	495	103	13	14	1720.0	1,853	699	821	92	425	16	69	7,234	18	2.59	2.22	1.16	0.48	6.8	5.9	1.32	.284	4.30	96	3.87	100	9.70	-7.7
23	Wilbur Cooper W. Cooper	120	95	.558	248	221	3.36	577	151	16	3	1793.0	1,946	669	805	74	395	51	18	7,562	14	2.90	1.98	1.46	0.37	7.6	5.2	1.31	.290	4.04	87	3.62	93	9.77	54.9
24	Walter Johnson W. Johnson	120	88	.577	258	227	3.33	895	143	24	12	1823.2	1,768	675	799	66	545	63	28	7,669	25	4.42	2.69	1.64	0.33	11.7	7.1	1.27	.279	3.94	84	3.49	89	8.73	88
25	Bullet Joe Bush B. Joe Bush	118	94	.557	270	215	3.97	631	129	13	11	1725.2	1,777	761	863	79	687	39	44	7,450	41	3.29	3.58	0.92	0.41	8.5	9.2	1.43	.282	4.50	98	4.10	102	9.27	-18.7