Alex Rodriguez has smashed the most career grand slams, with 25 grand slams.

	NAME	GRANDSLAM	G	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Alex Rodriguez A. Rodriguez	25	2,784	10,566	2,021	3,115	548	31	696	2,086	1,338	176	2,287	329	76	12,207	5,813	1,275	16	111	97	261	.295	.380	.550	.930
2	Manny Ramirez M. Ramirez	21	2,302	8,244	1,544	2,574	547	20	555	1,831	1,329	109	1,813	38	33	9,774	4,826	1,122	2	90	216	243	.312	.411	.585	.996
3	Eddie Murray E. Murray	19	3,026	11,336	1,627	3,255	560	35	504	1,917	1,333	18	1,516	110	43	12,817	5,397	1,099	2	128	222	315	.287	.359	.476	.836
4	Robin Ventura R. Ventura	18	2,079	7,064	1,006	1,885	338	14	294	1,182	1,075	23	1,179	24	38	8,271	3,133	646	33	76	132	177	.267	.362	.444	.806
5	Carlos Lee C. Lee	17	2,099	7,983	1,125	2,273	469	19	358	1,363	655	47	984	125	47	8,786	3,854	846	3	98	60	206	.285	.339	.483	.821
6	Albert Pujols A. Pujols	16	3,080	11,421	1,914	3,384	686	16	703	2,218	1,373	123	1,404	117	43	13,041	6,211	1,405	1	123	316	426	.296	.374	.544	.918
7	Ryan Howard R. Howard	15	1,572	5,707	848	1,475	277	21	382	1,194	709	59	1,843	12	5	6,530	2,940	680	0	55	154	116	.258	.343	.515	.859
8	Richie Sexson R. Sexson	15	1,367	4,928	748	1,286	260	17	306	943	588	52	1,313	14	13	5,604	2,498	583	0	36	31	144	.261	.344	.507	.851
9	Ken Griffey Jr. K. Griffey Jr.	15	2,671	9,801	1,662	2,781	524	38	630	1,836	1,312	81	1,779	184	69	11,304	5,271	1,192	8	102	246	199	.284	.370	.538	.907
10	Jason Giambi J. Giambi	14	2,260	7,267	1,227	2,010	405	9	440	1,441	1,366	180	1,572	20	12	8,908	3,753	854	2	93	97	166	.277	.399	.516	.916
11	Mike Piazza M. Piazza	14	1,912	6,911	1,048	2,127	344	8	427	1,335	759	30	1,113	17	20	7,745	3,768	779	0	45	146	229	.308	.377	.545	.922
12	Mark McGwire M. McGwire	14	1,874	6,187	1,167	1,626	252	6	583	1,414	1,317	75	1,596	12	8	7,660	3,639	841	3	78	150	147	.263	.394	.588	.982
13	Carlos Delgado C. Delgado	13	2,035	7,283	1,241	2,038	483	18	473	1,512	1,109	172	1,745	14	8	8,657	3,976	974	0	93	186	152	.280	.383	.546	.929
14	Jeff Kent J. Kent	13	2,298	8,498	1,320	2,461	560	47	377	1,518	801	125	1,522	94	60	9,537	4,246	984	10	103	61	224	.290	.356	.500	.855
15	Albert Belle A. Belle	13	1,539	5,853	974	1,726	389	21	381	1,239	683	55	961	88	41	6,673	3,300	791	4	78	91	193	.295	.369	.564	.933
16	Gary Sheffield G. Sheffield	13	2,576	9,217	1,636	2,689	467	27	509	1,676	1,475	135	1,171	253	104	10,947	4,737	1,003	9	111	130	235	.292	.393	.514	.907
17	Harold Baines H. Baines	13	2,830	9,908	1,299	2,866	488	49	384	1,628	1,062	14	1,441	34	34	11,092	4,604	921	9	99	187	298	.289	.356	.465	.820
18	Dave Kingman D. Kingman	13	1,941	6,677	901	1,575	240	25	442	1,210	608	53	1,816	85	49	7,429	3,191	707	16	75	72	139	.236	.302	.478	.780
19	Manny Machado M. Machado	12	1,767	6,927	1,011	1,933	373	18	345	1,063	620	27	1,324	105	39	7,648	3,377	736	14	60	69	212	.279	.338	.488	.825
20	Edwin Encarnacion E. Encarnacion	12	1,960	7,040	1,099	1,832	370	10	424	1,261	903	105	1,426	61	14	8,114	3,494	804	0	66	54	185	.260	.350	.496	.846
21	Mark Teixeira M. Teixeira	12	1,862	6,936	1,099	1,862	408	18	409	1,298	918	111	1,441	26	7	8,029	3,533	835	0	64	91	158	.268	.360	.509	.869
22	Travis Hafner T. Hafner	12	1,183	4,058	619	1,107	250	13	213	731	598	90	976	11	7	4,775	2,022	476	0	29	81	86	.273	.376	.498	.874
23	Adam Dunn A. Dunn	12	2,001	6,883	1,097	1,631	334	10	462	1,168	1,317	86	2,379	63	25	8,328	3,371	806	2	40	122	100	.237	.364	.490	.854
24	Miguel Tejada M. Tejada	12	2,171	8,434	1,230	2,407	468	23	307	1,302	553	122	1,079	85	38	9,203	3,842	798	23	71	73	277	.285	.336	.456	.791
25	Derrek Lee D. Lee	12	1,942	6,962	1,081	1,959	432	30	331	1,078	874	70	1,622	104	48	7,963	3,444	793	2	55	72	199	.281	.365	.495	.859