Since 1960, Rickey Henderson has the most runs, with 2,295 runs.

	NAME	R	G	AB	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS	WRC	WRAA	WOBA	WRC+	BRAA
1	Rickey Henderson R. Henderson	2,295	3,081	10,961	3,055	510	66	297	1,115	2,190	98	1,694	1,406	335	13,346	4,588	873	30	67	61	172	.279	.401	.419	.820	2074	509.6	.372	132	507.9
2	Barry Bonds B. Bonds	2,227	2,986	9,847	2,935	601	77	762	1,996	2,558	106	1,539	514	141	12,606	5,976	1,440	4	91	688	165	.298	.444	.607	1.051	2663	1,143.3	.435	172	1,142
3	Pete Rose P. Rose	2,165	3,562	14,053	4,256	746	135	160	1,314	1,566	107	1,143	198	149	15,861	5,752	1,041	56	79	167	247	.303	.375	.409	.784	2190	480.1	.354	121	368.7
4	Alex Rodriguez A. Rodriguez	2,021	2,784	10,566	3,115	548	31	696	2,086	1,338	176	2,287	329	76	12,207	5,813	1,275	16	111	97	261	.295	.380	.550	.930	2178	690.1	.395	141	629.5
5	Derek Jeter D. Jeter	1,923	2,747	11,195	3,465	544	66	260	1,311	1,082	170	1,840	358	97	12,602	4,921	870	97	58	39	287	.310	.377	.440	.817	1877	346.6	.360	119	305.9
6	Albert Pujols A. Pujols	1,914	3,080	11,421	3,384	686	16	703	2,218	1,373	123	1,404	117	43	13,041	6,211	1,405	1	123	316	426	.296	.374	.544	.918	2233	685	.385	141	673
7	Craig Biggio C. Biggio	1,844	2,850	10,876	3,060	668	55	291	1,175	1,160	285	1,753	414	124	12,503	4,711	1,014	101	81	68	150	.281	.363	.433	.796	1768	248.9	.352	115	238.9
8	Carl Yastrzemski C. Yastrzemski	1,816	3,308	11,988	3,419	646	59	452	1,844	1,845	40	1,393	168	116	13,991	5,539	1,157	13	105	190	323	.285	.379	.462	.841	2155	643.2	.375	130	469.8
9	Paul Molitor P. Molitor	1,782	2,683	10,835	3,319	605	114	234	1,307	1,094	47	1,244	504	131	12,160	4,854	953	75	109	100	209	.306	.369	.448	.817	1785	375.3	.361	122	319.5
10	Dave Winfield D. Winfield	1,669	2,973	11,003	3,110	540	88	465	1,833	1,216	25	1,686	223	96	12,358	5,221	1,093	19	95	172	319	.283	.353	.475	.827	1811	416.2	.364	128	400.6
11	Johnny Damon J. Damon	1,668	2,490	9,736	2,769	522	109	235	1,139	1,003	50	1,257	408	103	10,917	4,214	866	57	71	38	93	.284	.352	.433	.785	1471	131.2	.344	105	69.7
12	Rafael Palmeiro R. Palmeiro	1,663	2,831	10,472	3,020	585	38	569	1,835	1,353	87	1,348	97	40	12,046	5,388	1,192	15	119	172	232	.288	.371	.515	.885	1975	522.8	.380	130	453.5
13	Ken Griffey Jr. K. Griffey Jr.	1,662	2,671	9,801	2,781	524	38	630	1,836	1,312	81	1,779	184	69	11,304	5,271	1,192	8	102	246	199	.284	.370	.538	.907	1892	521.1	.384	132	453.4
14	Joe Morgan J. Morgan	1,650	2,649	9,277	2,517	449	96	268	1,133	1,865	40	1,015	689	162	11,329	3,962	813	51	96	76	105	.271	.392	.427	.819	1717	490	.372	135	447.2
15	Cal Ripken Jr. C. Ripken Jr.	1,647	3,001	11,551	3,184	603	44	431	1,695	1,129	66	1,305	36	39	12,883	5,168	1,078	10	127	107	350	.276	.340	.447	.788	1734	219.3	.346	111	175.1
16	Gary Sheffield G. Sheffield	1,636	2,576	9,217	2,689	467	27	509	1,676	1,475	135	1,171	253	104	10,947	4,737	1,003	9	111	130	235	.292	.393	.514	.907	1907	574.5	.391	141	567.2
17	Robin Yount R. Yount	1,632	2,856	11,008	3,142	583	126	251	1,406	966	48	1,350	271	105	12,249	4,730	960	104	123	95	217	.285	.342	.430	.772	1603	229.2	.343	113	193.9
18	Eddie Murray E. Murray	1,627	3,026	11,336	3,255	560	35	504	1,917	1,333	18	1,516	110	43	12,817	5,397	1,099	2	128	222	315	.287	.359	.476	.836	1904	432.6	.365	127	406.9
19	Chipper Jones C. Jones	1,619	2,499	8,984	2,726	549	38	468	1,623	1,512	18	1,409	150	46	10,614	4,755	1,055	3	97	177	253	.303	.401	.529	.930	1904	598.1	.397	141	563
20	Lou Brock L. Brock	1,610	2,616	10,332	3,023	486	141	149	900	761	49	1,730	938	307	11,235	4,238	776	47	46	124	114	.293	.343	.410	.753	1406	210.2	.336	109	113.1
21	Jim Thome J. Thome	1,583	2,543	8,422	2,328	451	26	612	1,699	1,747	69	2,548	19	20	10,313	4,667	1,089	1	74	173	165	.276	.402	.554	.956	1925	653.9	.406	145	589.5
22	George Brett G. Brett	1,583	2,707	10,349	3,154	665	137	317	1,596	1,096	33	908	201	97	11,624	5,044	1,119	26	120	229	235	.305	.369	.487	.857	1799	496.2	.374	132	436.3
23	Carlos Beltran C. Beltran	1,582	2,586	9,768	2,725	565	78	435	1,587	1,084	51	1,795	312	49	11,031	4,751	1,078	18	110	104	203	.279	.350	.486	.837	1621	297.8	.358	118	246.4
24	Tim Raines T. Raines	1,571	2,502	8,872	2,605	430	113	170	980	1,330	42	966	808	146	10,359	3,771	713	39	76	148	142	.294	.385	.425	.810	1517	318.9	.361	125	306.9
25	Hank Aaron H. Aaron	1,562	2,412	8,840	2,634	419	52	576	1,680	1,121	19	1,068	220	64	10,074	4,885	1,047	3	91	234	221	.298	.375	.553	.927	1771	695.7	.403	154	619.5