| NAME | QS | G | W | L | W% | GS | ERA | SO | CG | SHO | SV | IP | H | ER | R | HR | BB | HBP | GF | IBB | TBF | WP | K/9 | BB/9 | K/BB | HR/9 | K% | BB% | WHIP | BABIP | RA | H/9 | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | J. Santana | 94 | 134 | 70 | 32 | .686 | 134 | 2.89 | 983 | 6 | 4 | 0 | 912.1 | 705 | 293 | 314 | 103 | 198 | 18 | 0 | 1 | 3,592 | 26 | 9.70 | 1.95 | 4.96 | 1.02 | 27.4 | 5.5 | 0.99 | .263 | 3.10 | 6.95 | |
| 2 | R. Oswalt | 93 | 137 | 69 | 37 | .651 | 134 | 3.15 | 710 | 9 | 3 | 0 | 911.1 | 917 | 319 | 341 | 67 | 208 | 32 | 1 | 18 | 3,791 | 12 | 7.01 | 2.05 | 3.41 | 0.66 | 18.7 | 5.5 | 1.23 | .306 | 3.37 | 9.06 | |
| 3 | T. Glavine | 90 | 132 | 52 | 42 | .553 | 132 | 3.84 | 434 | 4 | 3 | 0 | 822.0 | 852 | 351 | 378 | 77 | 257 | 13 | 0 | 24 | 3,502 | 4 | 4.75 | 2.81 | 1.69 | 0.84 | 12.4 | 7.3 | 1.35 | .285 | 4.14 | 9.33 | |
| 4 | B. Webb | 87 | 135 | 55 | 46 | .545 | 135 | 3.30 | 708 | 11 | 6 | 0 | 908.1 | 848 | 333 | 391 | 65 | 300 | 24 | 0 | 25 | 3,801 | 39 | 7.02 | 2.97 | 2.36 | 0.64 | 18.6 | 7.9 | 1.26 | .290 | 3.87 | 8.40 | |
| 5 | J. Peavy | 87 | 123 | 58 | 33 | .637 | 123 | 2.97 | 844 | 5 | 3 | 0 | 795.0 | 664 | 262 | 279 | 67 | 233 | 30 | 0 | 23 | 3,250 | 12 | 9.55 | 2.64 | 3.62 | 0.76 | 26.0 | 7.2 | 1.13 | .288 | 3.16 | 7.52 | |
| 6 | C. Zambrano | 85 | 131 | 64 | 34 | .653 | 131 | 3.35 | 777 | 4 | 1 | 0 | 863.1 | 693 | 321 | 352 | 78 | 383 | 51 | 0 | 15 | 3,638 | 25 | 8.10 | 3.99 | 2.03 | 0.81 | 21.4 | 10.5 | 1.25 | .262 | 3.67 | 7.22 | |
| 7 | D. Davis | 82 | 136 | 47 | 46 | .505 | 136 | 4.09 | 677 | 3 | 2 | 0 | 826.0 | 805 | 375 | 405 | 80 | 369 | 21 | 0 | 16 | 3,592 | 20 | 7.38 | 4.02 | 1.83 | 0.87 | 18.8 | 10.3 | 1.42 | .297 | 4.41 | 8.77 | |
| 8 | B. Arroyo | 81 | 136 | 47 | 45 | .511 | 130 | 3.99 | 582 | 4 | 1 | 0 | 835.1 | 838 | 370 | 422 | 98 | 228 | 52 | 1 | 19 | 3,555 | 20 | 6.27 | 2.46 | 2.55 | 1.06 | 16.4 | 6.4 | 1.28 | .285 | 4.55 | 9.03 | |
| 9 | J. Lackey | 80 | 132 | 60 | 38 | .612 | 131 | 3.65 | 712 | 7 | 5 | 0 | 849.0 | 845 | 344 | 378 | 67 | 255 | 40 | 0 | 13 | 3,598 | 54 | 7.55 | 2.70 | 2.79 | 0.71 | 19.8 | 7.1 | 1.30 | .308 | 4.01 | 8.96 | |
| 10 | L. Hernandez | 80 | 137 | 50 | 49 | .505 | 137 | 4.29 | 551 | 12 | 2 | 0 | 921.2 | 995 | 439 | 462 | 114 | 324 | 33 | 0 | 30 | 3,990 | 8 | 5.38 | 3.16 | 1.70 | 1.11 | 13.8 | 8.1 | 1.43 | .297 | 4.51 | 9.72 | |
| 11 | D. Willis | 79 | 135 | 54 | 48 | .529 | 135 | 3.87 | 615 | 13 | 6 | 0 | 862.0 | 898 | 371 | 415 | 81 | 286 | 49 | 0 | 21 | 3,725 | 19 | 6.42 | 2.99 | 2.15 | 0.85 | 16.5 | 7.7 | 1.37 | .303 | 4.33 | 9.38 | |
| 12 | M. Buehrle | 79 | 130 | 54 | 40 | .574 | 130 | 3.88 | 527 | 11 | 3 | 0 | 887.0 | 952 | 382 | 428 | 111 | 184 | 23 | 0 | 16 | 3,698 | 3 | 5.35 | 1.87 | 2.86 | 1.13 | 14.3 | 5.0 | 1.28 | .295 | 4.34 | 9.66 | |
| 13 | CC Sabathia | 78 | 123 | 57 | 38 | .600 | 123 | 3.62 | 681 | 12 | 4 | 0 | 818.1 | 781 | 329 | 359 | 76 | 215 | 29 | 0 | 8 | 3,387 | 12 | 7.49 | 2.36 | 3.17 | 0.84 | 20.1 | 6.3 | 1.22 | .295 | 3.95 | 8.59 | |
| 14 | J. Garland | 76 | 131 | 58 | 41 | .586 | 129 | 4.28 | 438 | 7 | 5 | 0 | 857.2 | 901 | 408 | 444 | 105 | 221 | 21 | 0 | 12 | 3,607 | 10 | 4.60 | 2.32 | 1.98 | 1.10 | 12.1 | 6.1 | 1.31 | .282 | 4.66 | 9.45 | |
| 15 | B. Zito | 75 | 137 | 52 | 47 | .525 | 136 | 4.16 | 616 | 0 | 0 | 0 | 859.0 | 794 | 397 | 426 | 105 | 352 | 39 | 0 | 11 | 3,674 | 17 | 6.45 | 3.69 | 1.75 | 1.10 | 16.8 | 9.6 | 1.33 | .269 | 4.46 | 8.32 | |
| 16 | D. Lowe | 74 | 136 | 54 | 49 | .524 | 134 | 4.08 | 521 | 6 | 2 | 0 | 822.0 | 862 | 373 | 448 | 77 | 240 | 19 | 1 | 7 | 3,517 | 12 | 5.70 | 2.63 | 2.17 | 0.84 | 14.8 | 6.8 | 1.34 | .295 | 4.91 | 9.44 | |
| 17 | G. Maddux | 73 | 136 | 58 | 51 | .532 | 136 | 4.15 | 508 | 6 | 1 | 0 | 845.2 | 897 | 390 | 416 | 98 | 131 | 22 | 0 | 18 | 3,500 | 15 | 5.41 | 1.39 | 3.88 | 1.04 | 14.5 | 3.7 | 1.22 | .291 | 4.43 | 9.55 | |
| 18 | A. Pettitte | 73 | 120 | 52 | 35 | .598 | 117 | 3.58 | 569 | 2 | 1 | 0 | 735.0 | 735 | 292 | 323 | 68 | 211 | 6 | 1 | 12 | 3,066 | 11 | 6.97 | 2.58 | 2.70 | 0.83 | 18.6 | 6.9 | 1.29 | .302 | 3.96 | 9.00 | |
| 19 | B. Penny | 72 | 120 | 48 | 32 | .600 | 119 | 3.61 | 516 | 1 | 0 | 0 | 715.1 | 720 | 287 | 302 | 57 | 213 | 20 | 0 | 14 | 3,006 | 20 | 6.49 | 2.68 | 2.42 | 0.72 | 17.2 | 7.1 | 1.30 | .301 | 3.80 | 9.06 | |
| 20 | J. Beckett | 72 | 118 | 60 | 35 | .632 | 118 | 3.89 | 670 | 4 | 2 | 0 | 740.2 | 670 | 320 | 343 | 83 | 226 | 28 | 0 | 6 | 3,073 | 24 | 8.14 | 2.75 | 2.96 | 1.01 | 21.8 | 7.4 | 1.21 | .284 | 4.17 | 8.14 | |
| 21 | T. Hudson | 72 | 125 | 55 | 37 | .598 | 125 | 3.83 | 491 | 8 | 4 | 0 | 823.1 | 844 | 350 | 377 | 63 | 241 | 38 | 0 | 26 | 3,494 | 20 | 5.37 | 2.63 | 2.04 | 0.69 | 14.1 | 6.9 | 1.32 | .293 | 4.12 | 9.23 | |
| 22 | R. Clemens | 71 | 102 | 44 | 24 | .647 | 101 | 2.68 | 573 | 1 | 0 | 0 | 638.0 | 508 | 190 | 213 | 42 | 201 | 18 | 0 | 11 | 2,587 | 18 | 8.08 | 2.84 | 2.85 | 0.59 | 22.1 | 7.8 | 1.11 | .266 | 3.00 | 7.17 | |
| 23 | J. Smoltz | 71 | 173 | 44 | 25 | .638 | 100 | 3.17 | 662 | 6 | 2 | 44 | 749.0 | 702 | 264 | 279 | 67 | 168 | 14 | 61 | 22 | 3,067 | 21 | 7.95 | 2.02 | 3.94 | 0.81 | 21.6 | 5.5 | 1.16 | .295 | 3.35 | 8.44 | |
| 24 | D. Haren | 70 | 116 | 46 | 37 | .554 | 107 | 3.70 | 563 | 5 | 0 | 0 | 708.2 | 695 | 291 | 324 | 85 | 170 | 21 | 2 | 14 | 2,957 | 27 | 7.15 | 2.16 | 3.31 | 1.08 | 19.0 | 5.7 | 1.22 | .288 | 4.11 | 8.83 | |
| 25 | J. Vazquez | 70 | 130 | 51 | 45 | .531 | 129 | 4.46 | 739 | 6 | 1 | 0 | 833.0 | 821 | 413 | 437 | 120 | 212 | 38 | 0 | 11 | 3,507 | 31 | 7.98 | 2.29 | 3.49 | 1.30 | 21.1 | 6.0 | 1.24 | .292 | 4.72 | 8.87 | |