| NAME | QS | G | W | L | W% | GS | ERA | SO | CG | SHO | SV | IP | H | ER | R | HR | BB | HBP | GF | IBB | TBF | WP | K/9 | BB/9 | K/BB | HR/9 | K% | BB% | WHIP | BABIP | RA | H/9 | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | J. Santana | 139 | 193 | 99 | 48 | .673 | 193 | 2.86 | 1,335 | 9 | 6 | 0 | 1313.1 | 1,067 | 417 | 455 | 146 | 307 | 25 | 0 | 9 | 5,257 | 36 | 9.15 | 2.10 | 4.35 | 1.00 | 25.4 | 5.8 | 1.05 | .267 | 3.12 | 7.31 | |
| 2 | R. Oswalt | 132 | 199 | 94 | 53 | .639 | 196 | 3.35 | 1,013 | 15 | 5 | 0 | 1301.1 | 1,299 | 484 | 513 | 109 | 297 | 50 | 1 | 24 | 5,410 | 17 | 7.01 | 2.05 | 3.41 | 0.75 | 18.7 | 5.5 | 1.23 | .302 | 3.55 | 8.98 | |
| 3 | CC Sabathia | 124 | 192 | 93 | 56 | .624 | 192 | 3.40 | 1,129 | 24 | 10 | 0 | 1301.1 | 1,201 | 491 | 540 | 113 | 341 | 45 | 0 | 16 | 5,348 | 19 | 7.81 | 2.36 | 3.31 | 0.78 | 21.1 | 6.4 | 1.18 | .292 | 3.73 | 8.31 | |
| 4 | B. Arroyo | 122 | 203 | 77 | 69 | .527 | 197 | 4.09 | 872 | 8 | 3 | 0 | 1255.2 | 1,271 | 570 | 639 | 158 | 361 | 67 | 1 | 27 | 5,349 | 27 | 6.25 | 2.59 | 2.42 | 1.13 | 16.3 | 6.7 | 1.30 | .286 | 4.58 | 9.11 | |
| 5 | M. Buehrle | 122 | 197 | 82 | 62 | .569 | 197 | 3.86 | 772 | 13 | 4 | 0 | 1319.0 | 1,414 | 565 | 631 | 160 | 281 | 33 | 0 | 23 | 5,490 | 9 | 5.27 | 1.92 | 2.75 | 1.09 | 14.1 | 5.1 | 1.29 | .295 | 4.31 | 9.65 | |
| 6 | C. Zambrano | 119 | 189 | 87 | 47 | .649 | 189 | 3.49 | 1,059 | 6 | 3 | 0 | 1221.1 | 1,020 | 474 | 515 | 106 | 533 | 66 | 0 | 22 | 5,167 | 36 | 7.80 | 3.93 | 1.99 | 0.78 | 20.5 | 10.3 | 1.27 | .269 | 3.80 | 7.52 | |
| 7 | D. Davis | 118 | 196 | 62 | 68 | .477 | 196 | 4.12 | 935 | 3 | 2 | 0 | 1175.1 | 1,168 | 538 | 582 | 118 | 536 | 29 | 0 | 21 | 5,131 | 39 | 7.16 | 4.10 | 1.74 | 0.90 | 18.2 | 10.4 | 1.45 | .299 | 4.46 | 8.94 | |
| 8 | D. Haren | 117 | 182 | 76 | 55 | .580 | 173 | 3.52 | 992 | 9 | 2 | 0 | 1154.0 | 1,091 | 451 | 493 | 131 | 248 | 31 | 2 | 20 | 4,747 | 51 | 7.74 | 1.93 | 4.00 | 1.02 | 20.9 | 5.2 | 1.16 | .287 | 3.84 | 8.51 | |
| 9 | J. Garland | 117 | 196 | 83 | 62 | .572 | 194 | 4.33 | 637 | 9 | 5 | 0 | 1258.1 | 1,363 | 606 | 666 | 151 | 341 | 35 | 0 | 23 | 5,353 | 20 | 4.56 | 2.44 | 1.87 | 1.08 | 11.9 | 6.4 | 1.35 | .289 | 4.76 | 9.75 | |
| 10 | J. Peavy | 116 | 166 | 77 | 50 | .606 | 166 | 2.99 | 1,120 | 7 | 3 | 0 | 1070.1 | 890 | 356 | 377 | 92 | 326 | 36 | 0 | 24 | 4,369 | 20 | 9.42 | 2.74 | 3.44 | 0.77 | 25.6 | 7.5 | 1.14 | .286 | 3.17 | 7.48 | |
| 11 | D. Lowe | 115 | 204 | 83 | 70 | .542 | 202 | 4.03 | 779 | 7 | 2 | 0 | 1227.2 | 1,288 | 550 | 641 | 107 | 348 | 24 | 1 | 21 | 5,223 | 18 | 5.71 | 2.55 | 2.24 | 0.78 | 14.9 | 6.7 | 1.33 | .298 | 4.70 | 9.44 | |
| 12 | J. Lackey | 112 | 183 | 83 | 51 | .619 | 182 | 3.69 | 981 | 11 | 6 | 0 | 1188.2 | 1,183 | 487 | 533 | 110 | 342 | 59 | 0 | 15 | 5,021 | 65 | 7.43 | 2.59 | 2.87 | 0.83 | 19.5 | 6.8 | 1.28 | .304 | 4.04 | 8.96 | |
| 13 | B. Webb | 111 | 170 | 77 | 53 | .592 | 170 | 3.33 | 893 | 14 | 7 | 0 | 1139.0 | 1,060 | 422 | 492 | 80 | 367 | 37 | 0 | 30 | 4,765 | 47 | 7.06 | 2.90 | 2.43 | 0.63 | 18.7 | 7.7 | 1.25 | .289 | 3.89 | 8.38 | |
| 14 | L. Hernandez | 110 | 199 | 72 | 72 | .500 | 199 | 4.70 | 720 | 16 | 2 | 0 | 1285.1 | 1,472 | 671 | 703 | 158 | 434 | 36 | 0 | 39 | 5,607 | 12 | 5.04 | 3.04 | 1.66 | 1.11 | 12.8 | 7.7 | 1.48 | .309 | 4.92 | 10.31 | |
| 15 | R. Halladay | 110 | 169 | 89 | 45 | .664 | 168 | 3.14 | 888 | 35 | 10 | 0 | 1205.0 | 1,152 | 421 | 458 | 98 | 213 | 33 | 0 | 14 | 4,867 | 17 | 6.63 | 1.59 | 4.17 | 0.73 | 18.2 | 4.4 | 1.13 | .290 | 3.42 | 8.60 | |
| 16 | J. Vazquez | 109 | 195 | 78 | 71 | .523 | 194 | 4.22 | 1,177 | 10 | 1 | 0 | 1260.2 | 1,216 | 591 | 625 | 165 | 317 | 48 | 0 | 15 | 5,271 | 39 | 8.40 | 2.26 | 3.71 | 1.18 | 22.3 | 6.0 | 1.22 | .295 | 4.46 | 8.68 | |
| 17 | J. Beckett | 108 | 177 | 89 | 51 | .636 | 177 | 3.90 | 1,041 | 9 | 4 | 0 | 1127.1 | 1,041 | 489 | 522 | 126 | 315 | 44 | 0 | 8 | 4,681 | 32 | 8.31 | 2.51 | 3.30 | 1.01 | 22.2 | 6.7 | 1.20 | .290 | 4.17 | 8.31 | |
| 18 | A. Pettitte | 108 | 185 | 80 | 57 | .584 | 182 | 3.85 | 875 | 2 | 1 | 0 | 1133.2 | 1,161 | 485 | 536 | 107 | 342 | 17 | 1 | 17 | 4,781 | 20 | 6.95 | 2.72 | 2.56 | 0.85 | 18.3 | 7.2 | 1.33 | .306 | 4.26 | 9.22 | |
| 19 | B. Zito | 106 | 202 | 72 | 77 | .483 | 201 | 4.28 | 890 | 1 | 0 | 0 | 1231.0 | 1,159 | 586 | 630 | 142 | 535 | 51 | 0 | 29 | 5,310 | 22 | 6.51 | 3.91 | 1.66 | 1.04 | 16.8 | 10.1 | 1.38 | .275 | 4.61 | 8.47 | |
| 20 | A.J. Burnett | 105 | 166 | 70 | 53 | .569 | 164 | 3.83 | 1,031 | 11 | 3 | 0 | 1058.2 | 959 | 451 | 496 | 102 | 405 | 50 | 1 | 8 | 4,484 | 58 | 8.76 | 3.44 | 2.55 | 0.87 | 23.0 | 9.0 | 1.29 | .296 | 4.22 | 8.15 | |
| 21 | T. Lilly | 104 | 184 | 81 | 60 | .574 | 184 | 4.08 | 933 | 2 | 1 | 0 | 1094.0 | 1,004 | 496 | 522 | 159 | 383 | 25 | 0 | 15 | 4,622 | 29 | 7.68 | 3.15 | 2.44 | 1.31 | 20.2 | 8.3 | 1.27 | .271 | 4.29 | 8.26 | |
| 22 | A. Harang | 99 | 186 | 65 | 70 | .481 | 184 | 4.14 | 1,017 | 13 | 6 | 0 | 1185.1 | 1,240 | 545 | 578 | 163 | 305 | 35 | 0 | 30 | 5,035 | 39 | 7.72 | 2.32 | 3.33 | 1.24 | 20.2 | 6.1 | 1.30 | .306 | 4.39 | 9.42 | |
| 23 | C. Lee | 99 | 183 | 87 | 48 | .644 | 179 | 4.01 | 850 | 13 | 4 | 0 | 1134.0 | 1,177 | 505 | 547 | 127 | 304 | 36 | 1 | 8 | 4,825 | 29 | 6.75 | 2.41 | 2.80 | 1.01 | 17.6 | 6.3 | 1.31 | .299 | 4.34 | 9.34 | |
| 24 | J. Marquis | 98 | 194 | 80 | 68 | .541 | 191 | 4.49 | 649 | 6 | 3 | 0 | 1177.1 | 1,222 | 587 | 638 | 142 | 440 | 56 | 0 | 23 | 5,117 | 35 | 4.96 | 3.36 | 1.48 | 1.09 | 12.7 | 8.6 | 1.41 | .282 | 4.88 | 9.34 | |
| 25 | K. Millwood | 98 | 180 | 66 | 63 | .512 | 180 | 4.30 | 799 | 9 | 0 | 0 | 1088.0 | 1,193 | 520 | 570 | 120 | 343 | 40 | 0 | 14 | 4,739 | 26 | 6.61 | 2.84 | 2.33 | 0.99 | 16.9 | 7.2 | 1.41 | .312 | 4.72 | 9.87 | |