The St. Louis Cardinals have a run differential of 1,972 runs all-time.

	TEAM	DIFF	SEASON	G	W%	W	L	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Browns	-219	1892	155	.373	56	94	5,259	703	1,188	138	53	45	553	607	52	491	209		5,918	1,567	236					.226	.312	.298	.610
2	Browns	-84	1893	135	.432	57	75	4,879	745	1,288	152	98	10	616	524	63	251	250		5,466	1,666	260					.264	.343	.341	.684
3	Browns	-182	1894	133	.424	56	76	4,610	771	1,320	171	113	54	650	442	40	289	190		5,204	1,879	338	112				.286	.354	.408	.761
4	Browns	-284	1895	136	.298	39	92	4,814	752	1,356	155	88	39	633	388	28	283	208		5,294	1,804	282	64				.282	.339	.375	.714
5	Browns	-336	1896	131	.308	40	90	4,520	593	1,162	134	78	37	487	332	35	300	185		4,988	1,563	249	101				.257	.313	.346	.659
6	Browns	-496	1897	133	.221	29	102	4,673	592	1,285	151	67	32	496	354	76	314	172		5,183	1,666	250	80				.275	.336	.357	.693
7	Browns	-358	1898	154	.260	39	111	5,214	571	1,290	149	55	13	470	383	84	405	104		5,798	1,588	217	117				.247	.309	.305	.614
8	Perfectos	80	1899	155	.556	84	67	5,304	819	1,514	172	88	47	699	468	33	264	210		5,913	2,003	307	108				.285	.347	.378	.725
9	Cardinals	-4	1900	142	.464	65	75	4,877	744	1,420	141	81	36	602	406	81	318	243		5,444	1,831	258	80				.291	.356	.375	.731
10	Cardinals	103	1901	142	.543	76	64	5,039	792	1,430	187	94	39	657	314	90	540	190		5,565	1,922	320	122				.284	.337	.381	.718
11	Cardinals	-178	1902	140	.418	56	78	4,751	517	1,226	116	37	10	402	273	52	439	158		5,183	1,446	163	107				.258	.306	.304	.610
12	Cardinals	-282	1903	139	.314	43	94	4,689	505	1,176	138	65	8	404	277	34	522	171		5,096	1,468	211	96				.251	.297	.313	.610
13	Cardinals	7	1904	155	.487	75	79	5,104	602	1,292	175	66	24	456	343	46	514	199		5,619	1,671	265	126				.253	.306	.327	.633
14	Cardinals	-207	1905	154	.377	58	96	5,066	534	1,254	140	85	20	446	391	43	631	162		5,609	1,624	245	109				.248	.307	.321	.627
15	Cardinals	-132	1906	154	.347	52	98	5,075	475	1,195	137	69	9	362	361	38	682	110		5,613	1,497	215	139				.235	.291	.295	.586
16	Cardinals	-190	1907	155	.340	52	101	5,008	419	1,163	121	52	18	331	312	42	615	125		5,518	1,442	191	156				.232	.283	.288	.571
17	Cardinals	-252	1908	154	.318	49	105	4,959	372	1,105	134	57	17	301	282	45	623	150		5,450	1,404	208	164				.223	.271	.283	.554
18	Cardinals	-145	1909	154	.355	54	98	5,108	583	1,242	148	56	15	479	568	62	648	163		5,859	1,547	219	121				.243	.326	.303	.629
19	Cardinals	-81	1910	153	.412	63	90	4,912	637	1,217	167	70	15	527	655	78	581	179		5,798	1,569	252	153				.248	.345	.319	.665
20	Cardinals	-74	1911	158	.503	75	74	5,132	671	1,295	199	86	26	567	592	65	650	175		5,970	1,744	311	181				.252	.337	.340	.677
21	Cardinals	-166	1912	153	.412	63	90	5,092	659	1,366	190	77	27	561	508	47	620	193		5,813	1,791	294	166				.268	.340	.352	.692
22	Cardinals	-229	1913	153	.340	51	99	4,967	528	1,229	152	72	15	427	451	44	573	171	176	5,618	1,570	239	156				.247	.316	.316	.632
23	Cardinals	18	1914	157	.529	81	72	5,046	558	1,249	203	65	33	461	445	42	618	204		5,720	1,681	301	187				.248	.314	.333	.647
24	Cardinals	-11	1915	157	.471	72	81	5,106	590	1,297	159	92	20	483	457	42	658	162	144	5,780	1,700	271	175				.254	.320	.333	.653
25	Cardinals	-153	1916	153	.392	60	93	5,030	476	1,223	155	74	25	413	335	33	651	182		5,514	1,601	254	116				.243	.295	.318	.613
	Total	1,972		20,662	.513	10,537	9,994	706,761	92,453	187,820	31,844	7,052	12,867	84,513	64,211	5,205	98,224	15,018	3,616	791,295	272,369	51,763	11,974	3,144	3,776	10,141	.266	.330	.385	.715