The Chicago Cubs have the highest run differential by a team this season, with a differential of 101 runs.

Interpreted as:

MLB team best run differential this regular season

	TEAM	DIFF	SEASON	G	W%	W	L	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Cubs	101	2025	75	.600	45	30	2,593	401	658	135	15	104	393	263	20	592	90	15	2,905	1,135	254	6	23	9	34	.254	.325	.438	.762
2	Yankees	99	2025	75	.573	43	32	2,535	382	643	130	11	114	368	298	32	661	54	20	2,895	1,137	255	3	27	21	51	.254	.336	.449	.785
3	Tigers	81	2025	77	.623	48	29	2,605	379	656	124	14	94	365	250	31	672	27	6	2,913	1,090	232	4	23	7	43	.252	.322	.418	.741
4	Dodgers	76	2025	77	.610	47	30	2,628	426	694	131	13	117	408	294	28	623	44	13	2,982	1,202	261	3	29	17	58	.264	.341	.457	.798
5	Rays	71	2025	76	.553	42	34	2,557	360	654	121	6	80	341	239	26	642	101	23	2,849	1,027	207	7	20	3	50	.256	.323	.402	.725
6	Mets	60	2025	76	.592	45	31	2,536	335	620	123	13	95	326	275	48	595	61	10	2,886	1,054	231	3	24	14	65	.244	.327	.416	.743
7	Astros	53	2025	76	.579	44	32	2,551	324	658	111	7	81	309	221	35	586	43	18	2,836	1,026	199	9	20	7	66	.258	.323	.402	.726
8	Phillies	42	2025	76	.605	46	30	2,587	358	666	120	11	81	342	269	29	592	65	15	2,908	1,051	212	7	16	9	46	.257	.332	.406	.739
9	Giants	41	2025	76	.553	42	34	2,494	320	579	111	12	71	302	277	28	641	42	16	2,835	927	194	14	22	6	51	.232	.313	.372	.685
10	Cardinals	36	2025	76	.539	41	35	2,587	359	664	133	4	72	339	246	42	600	42	14	2,906	1,021	209	9	22	11	55	.257	.329	.395	.723
11	Reds	32	2025	76	.513	39	37	2,546	351	629	126	7	84	337	263	23	661	61	23	2,856	1,021	217	6	18	7	45	.247	.321	.401	.722
12	Brewers	31	2025	76	.539	41	35	2,532	344	612	108	8	69	320	261	31	630	93	25	2,860	943	185	16	20	9	37	.242	.318	.372	.690
13	Braves	20	2025	74	.459	34	40	2,506	309	613	103	7	79	296	256	22	626	38	12	2,808	967	189	7	17	8	47	.245	.318	.386	.704
14	Red Sox	20	2025	77	.519	40	37	2,660	365	662	144	11	94	349	261	36	714	64	15	2,978	1,110	249	6	15	15	42	.249	.323	.417	.740
15	Rangers	20	2025	76	.487	37	39	2,495	276	573	107	8	78	265	209	29	616	63	18	2,755	930	193	3	19	6	38	.230	.295	.373	.667
16	Padres	20	2025	75	.533	40	35	2,505	317	626	113	11	64	293	235	21	531	55	15	2,804	953	188	18	25	8	51	.250	.317	.380	.697
17	Mariners	7	2025	74	.514	38	36	2,524	326	613	102	4	95	315	268	37	660	76	20	2,855	1,008	201	11	15	7	43	.243	.323	.399	.722
18	Twins	0	2025	75	.493	37	38	2,519	320	610	120	8	82	308	223	47	624	36	14	2,806	992	210	1	16	4	48	.242	.314	.394	.708
19	Diamondbacks	-3	2025	75	.507	38	37	2,546	389	651	136	17	108	381	273	35	580	56	17	2,896	1,145	261	13	29	9	50	.256	.333	.450	.782
20	Blue Jays	-14	2025	75	.533	40	35	2,525	321	644	130	3	77	309	241	29	512	38	12	2,835	1,011	210	16	24	13	59	.255	.324	.400	.725
21	Royals	-16	2025	76	.500	38	38	2,556	259	635	124	15	55	255	181	24	518	60	26	2,802	954	194	18	23	12	38	.248	.302	.373	.675
22	Guardians	-28	2025	74	.500	37	37	2,408	279	552	103	7	75	264	227	27	606	59	17	2,696	894	185	9	25	10	46	.229	.300	.371	.671
23	Angels	-61	2025	75	.480	36	39	2,497	305	559	96	8	107	294	189	39	731	35	14	2,749	992	211	7	17	9	43	.224	.287	.397	.684
24	Pirates	-65	2025	77	.390	30	47	2,542	247	573	93	13	53	237	254	28	670	69	22	2,846	851	159	7	15	11	67	.225	.301	.335	.636
25	White Sox	-69	2025	76	.316	24	52	2,493	267	555	117	6	60	256	248	15	665	55	15	2,787	864	183	11	20	4	42	.223	.295	.347	.641