The Houston Astros had the highest run differential by a team in 2019, with a differential of 280 runs.

	TEAM	DIFF	SEASON	G	W%	W	L	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Astros	280	2019	162	.660	107	55	5,613	920	1,538	323	28	288	891	645	66	1,166	67	27	6,391	2,781	639	10	57	17	146	.274	.352	.495	.848
2	Dodgers	273	2019	162	.654	106	56	5,493	886	1,414	302	20	279	861	607	81	1,356	57	10	6,281	2,593	601	55	45	47	100	.257	.338	.472	.810
3	Yankees	204	2019	162	.636	103	59	5,583	943	1,493	290	17	306	904	569	49	1,437	55	22	6,244	2,735	613	10	33	18	113	.267	.339	.490	.829
4	Twins	185	2019	162	.623	101	61	5,732	939	1,547	318	23	307	906	525	81	1,334	28	21	6,389	2,832	648	10	41	21	101	.270	.338	.494	.832
5	Athletics	165	2019	162	.599	97	65	5,561	845	1,384	292	23	257	800	578	87	1,338	49	21	6,269	2,493	572	7	36	17	140	.249	.327	.448	.776
6	Nationals	149	2019	162	.574	93	69	5,512	873	1,460	298	27	231	824	584	81	1,308	116	29	6,267	2,505	556	48	42	33	117	.265	.342	.454	.796
7	Rays	113	2019	162	.593	96	66	5,628	769	1,427	291	29	217	730	542	73	1,493	94	37	6,285	2,427	537	8	34	20	114	.254	.325	.431	.757
8	Braves	112	2019	162	.599	97	65	5,560	855	1,432	277	29	249	824	619	60	1,467	89	28	6,299	2,514	555	25	35	39	104	.258	.336	.452	.789
9	Indians	112	2019	162	.574	93	69	5,425	769	1,354	286	18	223	731	563	50	1,332	103	35	6,124	2,345	527	40	46	30	110	.250	.323	.432	.756
10	Cardinals	102	2019	162	.562	91	71	5,449	764	1,336	246	24	210	714	561	76	1,420	116	29	6,165	2,260	480	40	39	15	110	.245	.322	.415	.737
11	Cubs	97	2019	162	.519	84	78	5,461	814	1,378	270	26	256	783	581	83	1,460	45	24	6,194	2,468	552	30	39	33	127	.252	.331	.452	.783
12	Red Sox	73	2019	162	.519	84	78	5,770	901	1,554	345	27	245	857	590	49	1,382	68	30	6,473	2,688	617	20	44	36	127	.269	.340	.466	.806
13	Diamondbacks	70	2019	162	.525	85	77	5,633	813	1,419	288	40	220	778	540	70	1,360	88	14	6,314	2,447	548	31	40	36	120	.252	.323	.434	.757
14	Mets	54	2019	162	.531	86	76	5,624	791	1,445	280	17	242	767	516	95	1,384	56	27	6,290	2,485	539	28	27	34	129	.257	.328	.442	.770
15	Brewers	3	2019	162	.549	89	73	5,542	769	1,366	279	17	250	744	629	72	1,563	101	25	6,301	2,429	546	20	38	42	120	.246	.329	.438	.767
16	Reds	-10	2019	162	.463	75	87	5,450	701	1,328	235	27	227	679	492	89	1,436	80	38	6,094	2,298	489	30	33	25	111	.244	.315	.422	.736
17	Phillies	-20	2019	162	.500	81	81	5,571	774	1,369	311	26	215	742	562	57	1,453	78	18	6,258	2,377	552	34	34	47	97	.246	.319	.427	.746
18	Rangers	-68	2019	162	.481	78	84	5,540	810	1,374	296	24	223	765	534	67	1,578	131	38	6,202	2,387	543	17	44	18	98	.248	.319	.431	.750
19	Giants	-95	2019	162	.475	77	85	5,579	678	1,332	300	26	167	655	475	50	1,435	47	28	6,170	2,185	493	24	42	26	111	.239	.302	.392	.694
20	Angels	-99	2019	162	.444	72	90	5,542	769	1,368	268	21	220	734	586	67	1,276	65	20	6,241	2,338	509	4	42	29	143	.247	.324	.422	.746
21	Blue Jays	-102	2019	162	.414	67	95	5,493	726	1,299	270	21	247	697	509	45	1,514	51	20	6,089	2,352	538	14	28	10	107	.236	.305	.428	.733
22	Padres	-107	2019	162	.432	70	92	5,391	682	1,281	224	24	219	652	504	55	1,581	70	37	6,018	2,210	467	37	31	19	120	.238	.308	.410	.718
23	Rockies	-123	2019	162	.438	71	91	5,660	835	1,502	323	41	224	803	489	43	1,503	71	31	6,286	2,579	588	51	43	25	111	.265	.326	.456	.782
24	White Sox	-124	2019	161	.447	72	89	5,529	708	1,443	260	20	182	676	378	66	1,549	63	28	6,041	2,289	462	36	32	13	114	.261	.314	.414	.728
25	Mariners	-135	2019	162	.420	68	94	5,500	758	1,305	254	28	239	730	588	58	1,581	115	47	6,197	2,332	521	14	37	7	83	.237	.316	.424	.740