Between the 1920 and 1929 seasons, the St. Louis Cardinals had the most runs by a team in a game, with 28 runs versus the Phillies on July 6, 1929.

Interpreted as:

MLB team most run in a regular-season game 1920s

	TEAM	R	DATE	TM		OPP	RESULT	AB	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	AVG	OBP	SLG	OPS
1	Cardinals	28	7/6/1929	SLN	@	PHN	W 28-6	53	28	4	1	2	25	9	1	1	0	0	65	40	7	2	.528	.603	.755	1.358
2	Indians	27	7/7/1923	CLE	vs	BSA	W 27-3	43	24	5	2	0	25	14	1	1	4	2	61	33	7	3	.558	.672	.767	1.440
3	Cubs	26	8/25/1922	CHC	vs	PHN	W 26-23	46	25	8	0	3	24	10	1	4	1	0	59	42	11	2	.543	.632	.913	1.545
4	Athletics	24	5/1/1929	PHA	@	BSA	W 24-6	52	29	6	0	3	23	6	1	4	1	2	60	44	9	1	.558	.610	.846	1.456
5	Indians	24	7/29/1928	CLE	vs	NYY	W 24-6	52	27	2	1	0	24	4	0	5	2	0	58	31	3	2	.519	.554	.596	1.150
6	Giants	24	9/2/1925	NYG	@	PHN	W 24-9	58	30	6	0	3	24	2	0	5	0	0	61	45	9	1	.517	.533	.776	1.309
7	Pirates	24	6/22/1925	PIT	@	SLN	W 24-6	51	21	4	0	6	20	7	1	0	2	0	60	43	10	1	.412	.492	.843	1.335
8	Yankees	24	9/28/1923	NYY	@	BSA	W 24-4	55	30	8	0	2	21	6	0	7	2	0	62	44	10	1	.545	.590	.800	1.390
9	Cardinals	23	9/16/1926	SLN	@	PHN	W 23-3	49	22	5	0	0	18	8	0	5	5	0	57	27	5	0	.449	.526	.551	1.077
10	Phillies	23	8/25/1922	PHN	@	CHC	L 23-26	52	26	4	2	0	19	11	0	5	1	1	66	34	6	3	.500	.587	.654	1.241
11	Giants	22	9/10/1924	NYG	vs	BSN	W 22-1	50	27	3	3	3	21	4	0	2	4	0	56	45	9	2	.540	.574	.900	1.474
12	Indians	22	8/7/1923	CLE	@	WSH	W 22-2	46	26	3	4	0	19	8	0	2	0	1	56	37	7	2	.565	.630	.804	1.434
13	Giants	22	6/1/1923	NYG	@	PHN	W 22-8	52	23	5	2	1	20	9	1	6	2	1	63	35	8	1	.442	.532	.673	1.205
14	Senators	21	8/5/1929	WSH	vs	DET	W 21-5	41	21	1	2	1	16	6	0	1	4	0	51	29	4	4	.512	.574	.707	1.282
15	Athletics	21	7/25/1929	PHA	vs	CLE	W 21-3	46	25	6	0	4	20	4	0	0	4	0	52	43	10	2	.543	.580	.935	1.515
16	Reds	21	6/5/1929	CIN	vs	PHN	W 21-4	43	19	0	5	0	20	6	1	2	2	0	53	29	5	3	.442	.520	.674	1.194
17	Yankees	21	7/4/1927	NYY	vs	WSH	W 21-1	41	19	5	3	3	20	11	0	2	0	0	54	39	11	2	.463	.577	.951	1.528
18	Reds	21	8/11/1926	CIN	@	PHN	W 21-3	50	21	3	0	3	20	6	0	3	0	0	56	33	6	0	.420	.482	.660	1.142
19	Pirates	21	6/20/1925	PIT	vs	BKN	W 21-5	47	25	3	3	4	19	5	1	0	0	1	54	46	10	1	.532	.585	.979	1.564
20	Indians	21	4/14/1925	CLE	@	SLA	W 21-14	49	19	2	0	4	19	7	0	5	5	1	59	33	6	3	.388	.464	.673	1.138
21	Athletics	21	8/9/1923	PHA	vs	CWS	W 21-5	44	22	3	1	2	19	7	0	4	1	0	51	33	6	0	.500	.569	.750	1.319
22	Reds	21	7/13/1923	CIN	@	PHN	W 21-7	48	22	3	0	2	21	4	0	1	1	0	53	31	5	1	.458	.500	.646	1.146
23	Yankees	21	9/25/1921	NYY	vs	CLE	W 21-7	44	20	1	2	2	19	8	0	3	1	0	52	31	5	0	.455	.538	.705	1.243
24	Phillies	21	9/14/1920	PHN	vs	CIN	W 21-10	44	17	8	0	1	13	3	0	2	2	0	50	28	9	3	.386	.426	.636	1.062
25	Tigers	21	7/25/1920	DET	vs	SLA	W 21-8	46	22	2	3	0	20	6	0	2	1	0	52	30	5	0	.478	.538	.652	1.191