The Chicago White Sox put up the most runs by a team in a game in 1981, with 18 runs versus the Orioles on April 23, 1981.

Interpreted as:

MLB team most run in a regular-season game 1981

	TEAM	R	DATE	TM		OPP	RESULT	AB	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	White Sox	18	4/23/1981	CWS	vs	BAL	W 18-5	47	26	2	2	1	17	6	0	2	0	0	55	35	5	1	1	0	1	.553	.593	.745	1.337
2	Indians	17	8/30/1981	CLE	vs	SEA	W 17-11	40	16	5	0	0	15	6	0	3	2	0	48	21	5	0	2	2	1	.400	.458	.525	.983
3	Angels	17	6/3/1981	CAL	@	TOR	W 17-6	42	19	4	1	1	14	6	0	4	0	0	50	28	6	0	2	0	2	.452	.500	.667	1.167
4	Brewers	16	9/4/1981	MIL	@	MIN	W 16-5	43	18	2	0	4	16	6	2	2	0	0	52	32	6	0	1	0	2	.419	.500	.744	1.244
5	Dodgers	16	8/26/1981	LAD	@	PIT	W 16-6	46	19	5	1	0	13	5	0	5	1	0	53	26	6	1	1	0	0	.413	.462	.565	1.027
6	Athletics	16	8/24/1981	OAK	vs	CLE	W 16-4	40	20	3	2	3	14	1	0	3	0	1	44	36	8	1	2	0	0	.500	.488	.900	1.388
7	Pirates	16	6/2/1981	PIT	vs	CHC	W 16-3	39	19	5	0	0	15	9	1	5	1	0	51	24	5	1	1	1	2	.487	.580	.615	1.195
8	Dodgers	16	5/31/1981	LAD	vs	CIN	W 16-4	41	18	4	1	1	14	4	1	6	0	0	46	27	6	0	0	0	1	.439	.500	.659	1.159
9	Rangers	16	4/22/1981	TEX	@	BOS	W 16-8	44	18	6	0	1	16	4	1	5	0	0	51	27	7	0	2	0	1	.409	.451	.614	1.065
10	Athletics	16	4/17/1981	OAK	vs	SEA	W 16-1	41	18	1	0	5	16	2	2	10	1	0	46	34	6	1	0	0	0	.439	.489	.829	1.318
11	Royals	15	9/27/1981	KCR	vs	SEA	W 15-3	44	22	7	2	0	15	2	1	2	2	0	47	33	9	0	0	0	1	.500	.532	.750	1.282
12	Giants	15	6/2/1981	SFG	vs	CIN	W 15-7	34	15	2	0	2	15	6	0	2	0	0	43	23	4	2	1	1	0	.441	.512	.676	1.189
13	White Sox	15	5/23/1981	CWS	@	CAL	W 15-4	40	17	4	0	0	15	7	0	4	2	0	51	21	4	2	2	0	1	.425	.490	.525	1.015
14	Cardinals	15	5/19/1981	STL	vs	HOU	W 15-12	42	18	3	1	0	15	2	0	4	1	0	45	23	4	1	0	0	0	.429	.455	.548	1.002
15	Angels	15	5/9/1981	CAL	vs	DET	W 15-1	37	15	2	0	4	15	7	2	5	2	0	48	29	6	1	1	1	0	.405	.511	.784	1.294
16	Tigers	14	9/29/1981	DET	vs	BAL	W 14-0	36	12	2	1	3	12	9	0	5	0	0	45	25	6	0	0	2	1	.333	.467	.694	1.161
17	Cubs	14	9/27/1981	CHC	vs	PHI	W 14-0	41	18	6	1	3	14	3	0	4	0	0	45	35	10	0	1	1	0	.439	.467	.854	1.320
18	Phillies	14	9/24/1981	PHI	@	STL	W 14-6	45	20	3	0	1	14	2	0	4	0	1	47	26	4	0	0	0	1	.444	.468	.578	1.046
19	Orioles	14	9/8/1981	BAL	vs	CLE	W 14-5	39	17	7	0	2	14	6	0	7	0	0	47	30	9	0	2	0	0	.436	.489	.769	1.259
20	Tigers	14	5/19/1981	DET	vs	TEX	W 14-1	38	16	1	1	1	14	8	0	5	0	1	46	22	3	0	0	1	1	.421	.522	.579	1.101
21	White Sox	13	10/4/1981	CWS	vs	MIN	W 13-12	36	14	1	0	1	11	10	0	4	1	1	48	18	2	1	1	0	3	.389	.511	.500	1.011
22	White Sox	13	8/23/1981	CWS	@	TOR	W 13-2	46	21	4	1	2	12	2	3	3	1	0	52	33	7	0	1	2	0	.457	.500	.717	1.217
23	Mariners	13	8/14/1981	SEA	@	MIN	W 13-3	45	18	1	0	4	12	2	0	1	0	0	47	31	5	0	0	0	1	.400	.426	.689	1.114
24	Mets	13	5/25/1981	NYM	vs	PHI	W 13-3	36	15	2	1	1	13	4	1	3	1	0	43	22	4	1	1	0	2	.417	.476	.611	1.087
25	Rangers	13	5/18/1981	TEX	@	DET	W 13-5	43	19	3	0	1	12	9	2	5	2	0	54	25	4	0	0	1	2	.442	.556	.581	1.137