The Colorado Rockies and the New York Yankees were tied for the most runs in a game in 2005, with 20 runs.

Interpreted as:

MLB team most run in a regular-season game 2005

	TEAM	R	DATE	TM		OPP	RESULT	AB	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Rockies	20	9/20/2005	COL	vs	SDP	W 20-1	48	23	5	1	4	20	3	1	6	0	0	53	42	10	0	1	0	0	.479	.509	.875	1.384
2	Yankees	20	6/21/2005	NYY	vs	TBD	W 20-11	46	23	4	1	6	20	4	0	5	0	0	51	47	11	0	1	1	0	.500	.529	1.022	1.551
3	Yankees	19	4/18/2005	NYY	vs	TBD	W 19-8	45	20	4	0	3	19	7	2	3	0	0	54	33	7	0	0	1	0	.444	.537	.733	1.270
4	Mets	18	8/24/2005	NYM	@	ARI	W 18-4	43	20	7	1	5	16	7	1	3	1	0	53	44	13	1	1	1	1	.465	.538	1.023	1.562
5	Rangers	18	6/30/2005	TEX	vs	LAA	W 18-5	39	15	3	0	8	17	8	0	9	0	0	47	42	11	0	0	0	0	.385	.489	1.077	1.566
6	Pirates	18	6/11/2005	PIT	vs	TBD	W 18-2	46	20	3	1	1	18	4	1	8	0	0	52	28	5	0	1	0	0	.435	.481	.609	1.089
7	Rangers	18	5/21/2005	TEX	vs	HOU	W 18-3	40	17	3	0	8	17	5	0	9	0	1	45	44	11	0	0	0	0	.425	.489	1.100	1.589
8	Rockies	18	5/13/2005	COL	vs	ARI	W 18-3	44	19	7	0	3	18	5	1	7	1	0	50	35	10	0	0	0	0	.432	.500	.795	1.295
9	Orioles	17	9/27/2005	BAL	vs	NYY	W 17-9	37	14	4	0	3	16	9	1	5	1	0	48	27	7	0	1	0	0	.378	.500	.730	1.230
10	Yankees	17	9/13/2005	NYY	@	TBD	W 17-3	45	20	1	0	1	17	9	0	4	0	0	54	24	2	0	0	0	1	.444	.537	.533	1.070
11	Royals	17	9/4/2005	KCR	vs	TEX	W 17-8	40	18	5	0	3	16	5	0	3	0	0	46	32	8	0	1	0	1	.450	.500	.800	1.300
12	Tigers	17	8/21/2005	DET	vs	TOR	W 17-6	38	15	4	0	3	17	5	3	4	0	0	48	28	7	0	2	0	0	.395	.479	.737	1.216
13	Reds	17	8/19/2005	CIN	vs	ARI	W 17-3	36	15	4	1	4	17	9	2	7	0	0	49	33	9	1	1	1	1	.417	.542	.917	1.458
14	Red Sox	17	7/15/2005	BOS	vs	NYY	W 17-1	39	15	8	0	2	17	9	0	5	0	0	48	29	10	0	0	0	0	.385	.500	.744	1.244
15	Red Sox	17	5/28/2005	BOS	@	NYY	W 17-1	52	27	1	0	3	17	2	1	5	0	0	57	37	4	1	1	0	0	.519	.536	.712	1.247
16	Phillies	16	9/28/2005	PHI	vs	NYM	W 16-6	40	20	1	1	3	15	7	0	10	0	0	51	32	5	1	3	2	0	.500	.540	.800	1.340
17	Red Sox	16	8/10/2005	BOS	vs	TEX	W 16-5	39	15	4	0	1	12	7	1	6	0	0	48	22	5	0	1	1	0	.385	.479	.564	1.043
18	Athletics	16	8/6/2005	OAK	@	KCR	W 16-1	45	18	5	0	2	16	10	0	6	0	0	55	29	7	0	0	0	1	.400	.509	.644	1.154
19	Marlins	16	7/23/2005	FLA	@	SFG	W 16-4	41	20	6	0	2	15	7	0	2	1	1	51	32	8	1	2	1	2	.488	.540	.780	1.320
20	Athletics	16	6/26/2005	OAK	vs	SFG	W 16-0	47	24	8	0	2	16	3	0	0	0	0	50	38	10	0	0	0	1	.511	.540	.809	1.349
21	Pirates	16	5/8/2005	PIT	@	ARI	W 16-2	43	17	4	0	3	16	6	0	4	3	0	50	30	7	0	1	0	0	.395	.460	.698	1.158
22	Braves	16	5/8/2005	ATL	vs	HOU	W 16-0	40	17	4	0	5	16	2	0	9	0	0	43	36	9	0	1	0	0	.425	.442	.900	1.342
23	Rangers	16	5/4/2005	TEX	@	OAK	W 16-7	45	18	1	0	3	15	7	1	10	0	0	53	28	4	0	0	1	1	.400	.491	.622	1.113
24	Mets	16	4/19/2005	NYM	@	PHI	W 16-4	42	15	1	1	7	16	6	1	9	0	0	49	39	9	0	0	2	0	.357	.449	.929	1.378
25	Cubs	16	4/4/2005	CHC	@	ARI	W 16-6	49	23	4	0	2	15	2	0	8	0	0	51	33	6	0	0	0	2	.469	.490	.673	1.164