The Cleveland Blues have the most runs by a team in a game on May 5, with 22 runs against the Buffalo Bisons on May 5, 1880.

	TEAM	R	DATE	TM		OPP	RESULT	AB	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Blues	22	5/5/1880	CLE	vs	BUF	W 22-3
2	Cubs	21	5/5/1938	CHC	vs	PHN	W 21-2	40	18	3	3	2	20	13	0	2	0	0	53	33	8	0			2	.450	.585	.825	1.410
3	Brewers	21	5/5/1901	MIL	vs	CWS	W 21-7	53	25	6	1	1	18	2	0	-10	2	-10	57	36	8	2		-10	-10	.472	.491	.679	1.170
4	Cubs	20	5/5/2001	CHC	vs	LAD	W 20-1	39	18	2	0	3	17	9	0	13	0	1	50	29	5	2	0	0	2	.462	.563	.744	1.306
5	Ward's Wonders	20	5/5/1890	BKP	vs	BSP	W 20-4
6	Athletics	18	5/5/1962	KCA	vs	CLE	W 18-6	46	21	1	0	4	15	3	1	6	0	0	51	34	5	0	1	1	0	.457	.490	.739	1.229
7	Dodgers	18	5/5/1943	BKN	vs	PHN	W 18-6	44	23	7	0	1	18	4	1	0	1	0	49	33	8	0			0	.523	.571	.750	1.321
8	Yankees	18	5/5/1931	NYY	vs	WSH	W 18-8	41	19	5	0	2	18	7	0	5	0	0	49	30	7	1				.463	.542	.732	1.273
9	Red Sox	18	5/5/1930	BSA	vs	CLE	W 18-3	46	23	5	2	0	17	6	0	0	0	0	53	32	7	1				.500	.558	.696	1.253
10	Athletics	18	5/5/1891	PHA	vs	BAL	W 18-5
11	Cowboys	18	5/5/1889	KCC	vs	STL	W 18-12
12	Browns	18	5/5/1888	STL	@	LOU	W 18-1
13	Rockies	17	5/5/2016	COL	@	SFG	W 17-7	45	17	6	0	2	17	1	1	3	0	0	48	29	8	1	0	0	0	.378	.404	.644	1.049
14	Rangers	17	5/5/2000	TEX	vs	OAK	W 17-16	44	21	3	0	1	17	5	1	5	0	1	51	27	4	1	0	0	1	.477	.540	.614	1.154
15	Yankees	17	5/5/1951	NYY	@	SLA	W 17-6	48	21	7	0	3	13	8	0	5	2	1	57	37	10	1		0	1	.438	.518	.771	1.289
16	Cubs	17	5/5/1937	CHC	@	PHN	W 17-4	39	17	1	1	3	16	8	3	3	3	0	51	29	5	1			2	.436	.560	.744	1.304
17	Orioles	17	5/5/1885	BAL	vs	NYM	W 17-4
18	Grays	17	5/5/1882	PRO	@	WOR	W 17-2
19	Athletics	16	5/5/2000	OAK	@	TEX	L 16-17	43	16	3	0	5	16	8	0	8	0	1	51	34	8	0	0	0	0	.372	.471	.791	1.261
20	Red Sox	16	5/5/1988	BOS	vs	CWS	W 16-3	40	18	6	0	1	15	6	0	2	0	0	47	27	7	1	0	0	1	.450	.522	.675	1.197
21	Tigers	16	5/5/1956	DET	@	BOS	W 16-4	47	20	5	0	1	15	7	1	5	1	1	55	28	6	0	0	1	0	.426	.509	.596	1.105
22	Red Stockings	16	5/5/1888	CIN	vs	KCC	W 16-6
23	Grays	16	5/5/1887	BKN	vs	NYM	W 16-13
24	Indians	15	5/5/1991	CLE	@	OAK	W 15-6	46	19	5	1	2	14	4	0	8	0	0	51	32	8	0	1	0	0	.413	.451	.696	1.147
25	Giants	15	5/5/1945	NYG	vs	BSN	W 15-5	34	11	2	0	1	14	9	1	1	0	0	44	16	3	0			2	.324	.477	.471	.948