The Colorado Rockies and the Chicago White Sox were tied for the most runs in a game in 2006, with 20 runs.

Interpreted as:

MLB team most runs in a regular-season game 2006

	TEAM	R	DATE	TM		OPP	RESULT	AB	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Rockies	20	9/18/2006	COL	vs	SFG	W 20-8	41	19	5	0	4	20	7	1	7	0	0	51	36	9	2	0	0	0	.463	.551	.878	1.429
2	White Sox	20	6/20/2006	CWS	vs	STL	W 20-6	49	24	3	0	4	19	1	2	5	0	0	52	39	7	0	0	0	0	.490	.519	.796	1.315
3	Dodgers	19	9/28/2006	LAD	@	COL	W 19-11	42	17	5	0	4	18	8	1	7	1	0	51	34	9	0	0	0	2	.405	.510	.810	1.319
4	Devil Rays	19	7/29/2006	TBD	@	NYY	W 19-6	43	17	6	0	4	18	5	2	5	1	0	52	35	10	1	1	0	0	.395	.471	.814	1.285
5	Indians	19	7/4/2006	CLE	vs	NYY	W 19-1	44	21	6	0	6	19	6	1	6	0	0	52	45	12	1	0	0	0	.477	.549	1.023	1.572
6	Marlins	18	7/5/2006	FLA	@	WSH	W 18-9	46	19	4	1	2	18	3	1	10	0	0	50	31	7	0	0	1	1	.413	.460	.674	1.134
7	Tigers	18	4/29/2006	DET	vs	MIN	W 18-1	48	23	6	0	4	15	2	1	10	1	0	51	41	10	0	0	0	0	.479	.510	.854	1.364
8	Orioles	18	4/19/2006	BAL	vs	CLE	W 18-9	46	21	4	0	3	17	1	0	3	2	0	47	34	7	0	0	0	1	.457	.468	.739	1.207
9	Tigers	17	9/15/2006	DET	vs	BAL	W 17-2	44	19	6	1	4	16	5	0	7	1	0	49	39	11	0	0	1	0	.432	.490	.886	1.376
10	Mets	17	7/8/2006	NYM	vs	FLA	W 17-3	40	16	2	2	3	17	4	1	4	0	0	45	31	7	0	0	0	0	.400	.467	.775	1.242
11	Yankees	17	4/29/2006	NYY	vs	TOR	W 17-6	41	15	3	0	4	16	9	0	9	2	0	50	30	7	0	0	0	0	.366	.480	.732	1.212
12	Yankees	16	9/27/2006	NYY	vs	BAL	W 16-5	41	18	4	0	5	16	4	1	4	0	0	47	37	9	0	1	0	0	.439	.489	.902	1.392
13	Yankees	16	9/25/2006	NYY	@	TBD	W 16-1	45	20	3	0	4	16	5	1	3	0	0	51	35	7	0	0	0	2	.444	.510	.778	1.288
14	Marlins	16	9/11/2006	FLA	vs	NYM	W 16-5	43	20	4	0	5	15	3	0	7	0	1	46	39	9	0	0	1	0	.465	.500	.907	1.407
15	Phillies	16	9/2/2006	PHI	vs	ATL	W 16-4	42	20	4	0	1	14	5	1	6	0	0	51	27	5	0	3	1	0	.476	.510	.643	1.153
16	Phillies	16	8/2/2006	PHI	@	STL	W 16-8	42	18	2	1	4	16	4	1	3	0	0	49	34	7	1	1	0	2	.429	.479	.810	1.289
17	Yankees	16	7/2/2006	NYY	vs	NYM	W 16-7	38	14	3	0	4	14	7	0	1	1	0	45	29	7	0	0	0	0	.368	.467	.763	1.230
18	Royals	16	6/8/2006	KCR	vs	TEX	W 16-12	41	18	2	0	2	16	5	0	6	0	0	47	26	4	0	1	0	1	.439	.489	.634	1.124
19	Rockies	16	6/7/2006	COL	vs	PIT	W 16-9	33	14	3	2	1	16	9	1	4	0	0	49	24	6	1	5	0	0	.424	.500	.727	1.227
20	Twins	16	5/20/2006	MIN	@	MIL	W 16-10	41	15	3	2	1	15	11	1	9	2	0	54	25	6	0	1	0	1	.366	.500	.610	1.110
21	Dodgers	16	5/19/2006	LAD	vs	LAA	W 16-3	47	25	4	1	1	16	3	1	7	1	1	53	34	6	1	1	1	1	.532	.558	.723	1.281
22	Brewers	16	4/29/2006	MIL	@	CHC	W 16-2	43	16	3	0	6	15	11	0	5	0	0	54	37	9	0	0	0	0	.372	.500	.860	1.360
23	Orioles	16	4/5/2006	BAL	vs	TBD	W 16-6	39	16	5	0	3	16	9	0	4	0	0	49	30	8	0	1	0	0	.410	.510	.769	1.279
24	Cubs	16	4/3/2006	CHC	@	CIN	W 16-7	42	18	5	1	1	15	7	0	4	0	0	52	28	7	1	2	2	1	.429	.490	.667	1.157
25	Tigers	15	9/23/2006	DET	@	KCR	W 15-4	43	17	4	1	1	14	9	1	4	0	0	53	26	6	0	0	0	1	.395	.509	.605	1.114