The Toronto Blue Jays put up the most runs by a team in a game in 2022, with 28 runs versus the Red Sox on July 22, 2022.

Interpreted as:

MLB team most runs in a regular-season game 2022

	TEAM	R	DATE	TM		OPP	RESULT	AB	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Blue Jays	28	7/22/2022	TOR	@	BOS	W 28-5	57	29	5	0	5	28	5	1	9	0	0	63	49	10	0	0	0	0	.509	.556	.860	1.415
2	Astros	21	8/18/2022	HOU	@	CWS	W 21-5	51	25	5	0	4	21	4	0	9	1	0	55	42	9	0	0	0	1	.490	.527	.824	1.351
3	Cubs	21	4/23/2022	CHC	vs	PIT	W 21-0	48	23	4	0	1	19	4	1	3	2	0	53	30	5	0	0	0	1	.479	.528	.625	1.153
4	Reds	20	5/26/2022	CIN	vs	CHC	W 20-5	38	20	3	1	2	20	7	0	4	0	1	49	31	6	1	3	1	0	.526	.563	.816	1.378
5	Brewers	19	7/1/2022	MIL	@	PIT	W 19-2	44	16	5	0	5	18	7	0	2	2	0	51	36	10	0	0	0	0	.364	.451	.818	1.269
6	Padres	19	6/15/2022	SDP	@	CHC	W 19-5	46	21	7	1	3	19	6	2	5	0	0	55	39	11	0	1	1	1	.457	.527	.848	1.375
7	Blue Jays	18	9/20/2022	TOR	@	PHI	W 18-11	49	21	7	1	2	17	3	1	8	0	0	53	36	10	0	0	0	1	.429	.472	.735	1.206
8	Phillies	18	8/31/2022	PHI	@	ARI	W 18-2	49	24	6	1	0	15	8	0	6	0	0	57	32	7	0	0	0	2	.490	.561	.653	1.214
9	Yankees	18	6/12/2022	NYY	vs	CHC	W 18-4	41	17	4	0	4	18	7	0	7	0	0	48	33	8	0	0	0	0	.415	.500	.805	1.305
10	Cardinals	18	5/22/2022	STL	@	PIT	W 18-4	47	20	5	0	3	18	4	0	4	1	0	52	34	8	0	1	0	0	.426	.462	.723	1.185
11	Brewers	18	5/4/2022	MIL	vs	CIN	W 18-4	39	17	3	0	3	18	9	2	6	0	0	51	29	6	0	1	0	1	.436	.549	.744	1.293
12	Red Sox	17	9/10/2022	BOS	@	BAL	W 17-4	46	21	3	0	2	17	6	2	7	0	0	54	30	5	0	0	0	1	.457	.537	.652	1.189
13	Guardians	17	4/10/2022	CLE	@	KCR	W 17-3	48	22	3	2	2	17	4	1	10	0	0	53	35	7	0	0	0	1	.458	.509	.729	1.239
14	Rangers	16	8/24/2022	TEX	@	COL	W 16-4	45	18	5	1	2	16	5	0	7	0	0	50	31	8	0	0	0	0	.400	.460	.689	1.149
15	Cardinals	16	8/20/2022	STL	@	ARI	W 16-7	43	18	3	1	4	15	5	0	6	1	1	49	35	8	0	1	0	0	.419	.469	.814	1.283
16	Rockies	16	8/9/2022	COL	vs	STL	W 16-5	46	22	3	0	3	16	2	0	5	0	0	48	34	6	0	0	0	0	.478	.500	.739	1.239
17	Yankees	16	7/6/2022	NYY	@	PIT	W 16-0	46	22	4	0	6	16	8	0	10	3	0	55	44	10	0	1	0	2	.478	.545	.957	1.502
18	Red Sox	16	5/26/2022	BOS	@	CWS	W 16-7	46	19	4	0	3	14	5	0	12	1	0	51	32	7	0	0	0	1	.413	.471	.696	1.166
19	Red Sox	16	5/24/2022	BOS	@	CWS	W 16-3	45	19	5	0	4	16	5	0	12	0	0	51	36	9	0	1	0	0	.422	.471	.800	1.271
20	Braves	16	4/12/2022	ATL	vs	WSH	W 16-4	42	19	5	0	3	14	9	1	8	0	0	52	33	8	0	0	0	0	.452	.558	.786	1.343
21	Cubs	15	10/5/2022	CHC	@	CIN	W 15-2	39	13	3	0	3	15	8	1	10	1	1	48	25	6	0	0	1	0	.333	.458	.641	1.099
22	Royals	15	8/28/2022	KCR	vs	SDP	W 15-7	42	18	3	0	2	14	6	1	9	3	0	50	27	5	0	1	0	0	.429	.500	.643	1.143
23	Orioles	15	8/19/2022	BAL	vs	BOS	W 15-10	40	18	6	0	5	15	3	1	6	0	0	45	39	11	0	1	0	0	.450	.489	.975	1.464
24	Cubs	15	7/22/2022	CHC	@	PHI	W 15-2	43	19	5	0	4	14	6	1	4	0	0	50	36	9	0	0	0	3	.442	.520	.837	1.357
25	Cubs	15	6/30/2022	CHC	vs	CIN	W 15-7	45	23	5	0	4	15	3	1	4	1	0	50	40	9	0	1	0	2	.511	.540	.889	1.429