4 teams were tied for the most strikeouts in a game in 1981, with 15 strikeouts. The first three are the New York Mets on September 16, 1981, the Seattle Mariners on September 3, 1981 and the Chicago Cubs on May 10, 1981.

Interpreted as:

MLB team most strikeout in a regular-season game 1981

	TEAM	SO	DATE	TM		OPP	RESULT	AB	R	H	2B	3B	HR	RBI	BB	HBP	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Mets	15	9/16/1981	NYM	vs	PHI	W 5-4	31	5	8	3	0	1	5	4	0	0	0	35	14	4	0	0	0	0	.258	.343	.452	.794
2	Mariners	15	9/3/1981	SEA	@	BOS	W 8-7	80	8	24	7	1	0	6	8	1	1	0	90	33	8	1	0	2	1	.300	.371	.413	.783
3	Cubs	15	5/10/1981	CHC	@	ATL	N 5-5	48	5	10	1	0	2	5	4	1	1	0	56	17	3	2	1	2	1	.208	.278	.354	.632
4	Orioles	15	4/25/1981	BAL	vs	BOS	W 7-2	35	7	12	3	0	0	6	3	0	0	0	38	15	3	0	0	0	1	.343	.395	.429	.823
5	Athletics	14	5/23/1981	OAK	vs	TOR	W 3-2	49	3	11	0	0	1	3	5	0	0	2	55	14	1	0	1	0	0	.224	.291	.286	.577
6	Athletics	14	5/3/1981	OAK	vs	NYY	L 2-3	40	2	9	0	0	0	2	0	0	1	0	40	9	0	0	0	0	0	.225	.225	.225	.450
7	Padres	13	10/3/1981	SDP	@	SFG	W 4-3	46	4	8	2	1	0	2	6	0	2	0	55	12	3	2	1	2	0	.174	.264	.261	.525
8	Expos	13	9/21/1981	MON	vs	PHI	W 1-0	52	1	7	1	0	0	1	12	0	2	0	66	8	1	2	0	4	2	.135	.297	.154	.451
9	Cubs	13	9/20/1981	CHC	@	MON	L 0-4	30	0	3	2	0	0	0	1	0	0	0	31	5	2	0	0	0	0	.100	.129	.167	.296
10	Cardinals	13	8/22/1981	STL	vs	LAD	L 2-3	29	2	4	0	0	0	2	4	0	1	1	33	4	0	0	0	0	1	.138	.242	.138	.380
11	Cubs	13	8/15/1981	CHC	vs	PIT	W 4-3	54	4	14	1	1	0	2	6	0	2	0	62	17	2	1	1	1	0	.259	.328	.315	.643
12	Cardinals	12	10/2/1981	STL	@	PIT	L 7-8	39	7	11	1	0	2	5	6	0	1	0	45	18	3	0	0	0	1	.282	.378	.462	.839
13	Braves	12	9/26/1981	ATL	vs	CIN	L 0-2	31	0	5	0	0	0	0	6	0	0	0	37	5	0	0	0	0	1	.161	.297	.161	.459
14	Blue Jays	12	9/22/1981	TOR	vs	OAK	L 2-3	45	2	9	1	0	0	2	8	0	1	0	54	10	1	1	0	1	1	.200	.321	.222	.543
15	Astros	12	9/14/1981	HOU	vs	CIN	L 2-4	32	2	4	1	0	0	2	1	0	0	0	33	5	1	0	0	0	0	.125	.152	.156	.308
16	Athletics	12	9/13/1981	OAK	vs	KCR	L 5-6	45	5	14	0	0	1	5	4	0	2	0	52	17	1	2	1	1	1	.311	.360	.378	.738
17	Red Sox	12	9/11/1981	BOS	@	NYY	L 1-4	28	1	2	0	0	0	1	5	0	0	0	34	2	0	0	1	0	0	.071	.206	.071	.277
18	Mets	12	8/24/1981	NYM	@	CIN	L 0-2	29	0	2	0	0	0	0	2	0	0	0	31	2	0	0	0	0	0	.069	.129	.069	.198
19	White Sox	12	8/18/1981	CWS	@	NYY	L 0-4	32	0	6	1	0	0	0	0	0	0	0	32	7	1	0	0	0	1	.188	.188	.219	.406
20	Braves	12	8/16/1981	ATL	@	LAD	L 5-6	39	5	11	1	0	3	5	0	0	1	0	39	21	4	0	0	0	0	.282	.282	.538	.821
21	Mets	12	6/10/1981	NYM	vs	CIN	L 0-2	33	0	6	0	0	0	0	1	0	1	0	34	6	0	0	0	0	0	.182	.206	.182	.388
22	Giants	12	6/5/1981	SFG	@	PIT	W 5-3	38	5	9	0	0	2	5	3	0	0	0	41	15	2	0	0	0	0	.237	.293	.395	.687
23	Athletics	12	5/21/1981	OAK	@	BOS	L 0-3	28	0	2	1	0	0	0	5	1	4	1	34	3	1	0	0	0	0	.071	.235	.107	.342
24	Athletics	12	5/9/1981	OAK	vs	MIL	W 6-5	45	6	15	2	0	1	5	5	0	0	1	53	20	3	3	0	2	2	.333	.400	.444	.844
25	Angels	12	5/4/1981	CAL	vs	NYY	L 2-4	30	2	4	2	0	1	2	2	0	0	0	32	9	3	0	0	0	1	.133	.188	.300	.488