The Detroit Tigers have the most wins by a team against left-handed pitchers this season, with 463 wins.

Interpreted as:

MLB team with most wins vs lefties this regular season

	TEAM	W	SEASON	L	W%	G	AB	H	2B	3B	HR	RBI	BB	HBP	SO	PA	TB	XBH	SH	SF	IBB	AVG	OBP	SLG	OPS
1	Tigers	463	2025	196	.703	54	586	153	30	4	19	87	60	3	155	659	248	53	3	7	3	.261	.329	.423	.752
2	Brewers	450	2025	287	.611	53	656	156	30	1	13	72	59	12	167	737	227	44	7	3	3	.238	.311	.346	.657
3	Yankees	424	2025	212	.667	51	545	147	36	2	26	94	74	9	142	636	265	64	0	8	12	.270	.362	.486	.848
4	Phillies	414	2025	330	.556	54	666	172	24	4	24	85	66	7	168	744	276	52	2	3	1	.258	.330	.414	.745
5	Padres	393	2025	236	.625	43	555	130	26	2	14	55	57	2	119	629	202	42	9	6	5	.234	.305	.364	.669
6	Cubs	370	2025	228	.619	50	529	138	25	4	23	80	59	3	115	598	240	52	3	4	1	.261	.336	.454	.790
7	Rays	362	2025	330	.523	54	622	139	23	1	19	60	57	7	158	692	221	43	0	5	1	.223	.294	.355	.649
8	Cardinals	360	2025	302	.544	47	581	142	35	0	12	65	66	7	151	662	213	47	3	5	3	.244	.326	.367	.693
9	Mariners	357	2025	283	.558	50	573	138	18	1	22	72	57	5	162	640	224	41	2	3	1	.241	.313	.391	.704
10	Mets	346	2025	226	.605	52	496	123	24	4	15	66	60	8	114	572	200	43	2	6	2	.248	.335	.403	.738
11	Dodgers	326	2025	324	.502	52	589	151	31	2	30	81	48	8	137	650	276	63	0	5	1	.256	.318	.469	.787
12	Twins	311	2025	190	.621	47	449	100	24	1	11	47	44	5	137	501	159	36	1	2	3	.223	.298	.354	.652
13	Red Sox	299	2025	349	.461	54	569	152	30	4	14	80	68	5	154	648	232	48	1	5	2	.267	.348	.408	.755
14	Diamondbacks	292	2025	373	.439	51	593	149	33	3	16	80	58	4	109	665	236	52	4	6	4	.251	.319	.398	.717
15	Royals	289	2025	195	.597	42	436	101	20	1	3	34	31	7	109	484	132	24	5	5	5	.232	.290	.303	.593
16	Reds	286	2025	321	.471	51	535	115	25	3	11	60	62	7	146	607	179	39	0	3	3	.215	.303	.335	.638
17	Marlins	281	2025	314	.472	50	527	126	28	3	7	51	50	5	126	595	181	38	9	4	2	.239	.309	.343	.652
18	Blue Jays	272	2025	276	.496	46	469	123	28	0	13	57	61	6	107	548	190	41	5	6	4	.262	.351	.405	.756
19	Giants	264	2025	344	.434	45	548	119	21	3	15	58	50	5	154	608	191	39	2	3	1	.217	.287	.349	.636
20	Nationals	253	2025	309	.450	50	505	118	29	1	10	62	43	6	134	562	179	40	2	6	0	.234	.298	.354	.653
21	Braves	245	2025	332	.425	48	517	113	26	3	13	57	49	3	146	577	184	42	3	5	2	.219	.287	.356	.643
22	Rangers	238	2025	333	.417	44	521	113	16	1	15	49	41	3	154	571	176	32	1	5	0	.217	.275	.338	.613
23	Guardians	235	2025	305	.435	52	478	106	21	1	9	49	43	7	137	540	156	31	4	8	3	.222	.291	.326	.617
24	White Sox	233	2025	313	.427	46	501	115	29	2	13	57	33	3	133	546	187	44	2	4	1	.230	.279	.373	.652
25	Athletics	225	2025	260	.464	50	442	120	20	1	14	50	37	1	116	485	184	35	1	3	0	.271	.327	.416	.743