The Kansas City Royals had the lowest run differential by a team in 2005, with a differential of -234 runs.

	TEAM	DIFF	SEASON	G	W%	W	L	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Royals	-234	2005	162	.346	56	106	5,503	701	1,445	289	34	126	653	424	63	1,008	53	33	6,086	2,180	449	46	50	23	139	.263	.320	.396	.716
2	Devil Rays	-186	2005	162	.414	67	95	5,552	750	1,519	289	40	157	717	412	69	990	151	49	6,118	2,359	486	34	51	25	133	.274	.329	.425	.754
3	Diamondbacks	-160	2005	162	.475	77	85	5,550	696	1,419	291	27	191	670	606	55	1,094	67	26	6,327	2,337	509	71	45	51	132	.256	.332	.421	.754
4	Rockies	-122	2005	162	.414	67	95	5,542	740	1,477	280	34	150	704	509	64	1,103	65	32	6,237	2,275	464	88	34	36	125	.267	.333	.411	.744
5	Giants	-96	2005	162	.463	75	87	5,462	649	1,427	299	26	128	617	431	49	901	71	35	6,077	2,162	453	91	44	26	147	.261	.319	.396	.714
6	Pirates	-89	2005	162	.414	67	95	5,573	680	1,445	292	38	139	656	471	72	1,092	73	30	6,221	2,230	469	56	49	38	130	.259	.322	.400	.723
7	Orioles	-71	2005	162	.457	74	88	5,551	729	1,492	296	27	189	700	447	54	902	83	37	6,134	2,409	512	40	42	31	145	.269	.327	.434	.761
8	Dodgers	-70	2005	162	.438	71	91	5,433	685	1,374	284	21	149	653	541	67	1,094	58	35	6,131	2,147	454	57	33	30	139	.253	.326	.395	.721
9	Reds	-69	2005	163	.451	73	89	5,565	820	1,453	335	15	222	784	611	62	1,303	72	23	6,320	2,484	572	43	39	42	116	.261	.339	.446	.785
10	Tigers	-64	2005	162	.438	71	91	5,602	723	1,521	283	45	168	678	384	53	1,038	66	28	6,135	2,398	496	44	52	24	137	.272	.321	.428	.750
11	Mariners	-52	2005	162	.426	69	93	5,507	699	1,408	289	34	130	657	466	48	986	102	47	6,095	2,155	453	37	37	50	115	.256	.317	.391	.709
12	Padres	-42	2005	162	.506	82	80	5,502	684	1,416	269	39	130	655	600	49	977	99	44	6,271	2,153	438	72	48	41	122	.257	.333	.391	.724
13	Nationals	-34	2005	162	.500	81	81	5,426	639	1,367	311	32	117	615	491	89	1,090	45	45	6,142	2,093	460	91	45	55	130	.252	.322	.386	.708
14	Marlins	-15	2005	162	.512	83	79	5,502	717	1,499	306	32	128	678	512	67	918	96	38	6,213	2,253	466	82	50	61	144	.272	.339	.409	.748
15	Cubs	-11	2005	162	.488	79	83	5,584	703	1,506	323	23	194	674	419	50	920	65	39	6,159	2,457	540	69	37	49	131	.270	.324	.440	.764
16	Rangers	7	2005	162	.488	79	83	5,716	865	1,528	311	29	260	834	495	48	1,112	67	15	6,300	2,677	600	9	32	20	123	.267	.329	.468	.798
17	Twins	26	2005	162	.512	83	79	5,564	688	1,441	269	32	134	644	485	59	978	102	44	6,192	2,176	435	42	42	49	155	.259	.323	.391	.714
18	Brewers	29	2005	162	.500	81	81	5,448	726	1,413	327	19	175	689	531	73	1,162	79	34	6,156	2,303	521	66	38	55	137	.259	.331	.423	.754
19	Blue Jays	70	2005	162	.494	80	82	5,581	775	1,480	307	39	136	735	486	89	955	72	35	6,233	2,273	482	21	56	18	126	.265	.331	.407	.738
20	Mets	74	2005	162	.512	83	79	5,505	722	1,421	279	32	175	683	486	48	1,075	153	40	6,146	2,289	486	69	38	49	103	.258	.322	.416	.738
21	Phillies	81	2005	162	.543	88	74	5,542	807	1,494	282	35	167	760	639	56	1,083	116	27	6,345	2,347	484	62	46	76	107	.270	.348	.423	.772
22	Astros	84	2005	163	.549	89	73	5,462	693	1,400	281	32	161	654	481	72	1,037	115	44	6,139	2,228	474	82	42	43	116	.256	.322	.408	.730
23	Braves	95	2005	162	.556	90	72	5,486	769	1,453	308	37	184	733	534	45	1,084	92	32	6,186	2,387	529	75	46	56	146	.265	.333	.435	.768
24	White Sox	96	2005	162	.611	99	63	5,529	741	1,450	253	23	200	713	435	79	1,002	137	67	6,145	2,349	476	53	49	27	122	.262	.322	.425	.747
25	Yankees	97	2005	162	.586	95	67	5,624	886	1,552	259	16	229	847	637	73	989	84	27	6,405	2,530	504	28	43	41	125	.276	.355	.450	.805