Dennis Eckersley had the most games pitched when striking out 1+ batter, with 823 games.

Interpreted as:

most 1 or more strikeout regular-season games by a pitcher

	NAME	G	SO	W	L	W%	GS	ERA	CG	SHO	SV	IP	H	ER	R	HR	BB	HBP	GF	IBB	TBF	WP	K/9	BB/9	K/BB	HR/9	K%	BB%	WHIP	BABIP	RA	H/9
1	Dennis Eckersley D. Eckersley	823	2,401	185	147	.557	345	3.37	100	20	280	3025.1	2,762	1,133	1,223	309	683	69	398	88	12,403	27	7.14	2.03	3.52	0.92	19.4	5.5	1.14	.274	3.64	8.22
2	Nolan Ryan N. Ryan	786	5,714	323	287	.530	763	3.14	222	61	3	5366.2	3,887	1,871	2,138	317	2,760	157	11	77	22,448	273	9.58	4.63	2.07	0.53	25.5	12.3	1.24	.264	3.59	6.52
3	Phil Niekro P. Niekro	781	3,342	312	258	.547	693	3.23	245	45	18	5244.2	4,796	1,881	2,188	466	1,723	116	52	80	21,877	215	5.73	2.96	1.94	0.80	15.3	7.9	1.24	.267	3.75	8.23
4	Hoyt Wilhelm H. Wilhelm	749	1,613	128	95	.574	52	2.23	20	5	158	1895.2	1,395	470	586	117	593	51	469	48	7,601	70	7.66	2.82	2.72	0.56	21.2	7.8	1.05	.244	2.78	6.62
5	Don Sutton D. Sutton	743	3,574	322	240	.573	732	3.17	177	58	1	5191.0	4,553	1,826	2,008	454	1,303	79	6	98	21,187	111	6.20	2.26	2.74	0.79	16.9	6.1	1.13	.260	3.48	7.89
6	Mariano Rivera M. Rivera	739	1,173	63	37	.630	9	1.94	0	0	429	915.1	669	197	211	45	206	32	612	27	3,614	11	11.53	2.03	5.69	0.44	32.5	5.7	0.96	.289	2.07	6.58
7	Lee Smith L. Smith	733	1,251	53	64	.453	6	2.74	0	0	355	1021.2	857	311	333	66	373	7	593	79	4,236	40	11.02	3.29	3.35	0.58	29.5	8.8	1.20	.312	2.93	7.55
8	Walter Johnson W. Johnson	733	3,456	399	255	.610	635	1.70	513	108	25	5657.1	4,645		1,783	93	1,305	198	94		22,572	147	5.50	2.08	2.65	0.15	15.3	5.8	1.05	.260	2.84	7.39
9	Gaylord Perry G. Perry	729	3,534	309	247	.556	667	2.97	303	53	8	5243.0	4,755	1,733	1,998	383	1,329	105	24	154	21,403	152	6.07	2.28	2.66	0.66	16.5	6.2	1.16	.272	3.43	8.16
10	Greg Maddux G. Maddux	725	3,371	351	222	.613	722	3.14	109	35	0	4918.0	4,619	1,717	1,932	348	971	135	2	177	20,030	70	6.17	1.78	3.47	0.64	16.8	4.8	1.14	.281	3.54	8.45
11	Kenley Jansen K. Jansen	721	1,237	45	25	.643	0	2.23	0	0	380	735.1	459	182	195	65	206	26	548	15	2,887	19	15.14	2.52	6.00	0.80	42.8	7.1	0.90	.291	2.39	5.62
12	Jesse Orosco J. Orosco	720	1,179	63	48	.568	3	2.28	0	0	102	965.0	665	244	276	68	373	20	343	56	3,896	30	11.00	3.48	3.16	0.63	30.3	9.6	1.08	.265	2.57	6.20
13	Steve Carlton S. Carlton	714	4,136	326	233	.583	697	3.15	254	55	2	5151.0	4,573	1,800	2,061	401	1,795	52	8	146	21,355	179	7.23	3.14	2.30	0.70	19.4	8.4	1.24	.279	3.60	7.99
14	Rich Gossage R. Gossage	712	1,502	98	80	.551	36	2.57	16	0	244	1531.0	1,170	438	493	93	576	33	497	74	6,236	48	8.83	3.39	2.61	0.55	24.1	9.2	1.14	.267	2.90	6.88
15	Francisco Rodriguez F. Rodriguez	711	1,142	42	37	.532	0	2.64	0	0	322	759.1	548	223	243	80	296	11	510	28	3,111	57	13.54	3.51	3.86	0.95	36.7	9.5	1.11	.296	2.88	6.50
16	Charlie Hough C. Hough	709	2,362	199	189	.513	416	3.52	106	13	44	3552.0	3,005	1,390	1,593	358	1,488	160	167	39	14,988	164	5.98	3.77	1.59	0.91	15.8	9.9	1.26	.249	4.04	7.61
17	Aroldis Chapman A. Chapman	706	1,273	53	28	.654	0	1.96	0	0	304	703.2	376	153	169	37	302	25	465	5	2,795	72	16.28	3.86	4.22	0.47	45.5	10.8	0.96	.293	2.16	4.81
18	Trevor Hoffman T. Hoffman	706	1,133	44	38	.537	0	2.23	0	0	434	793.1	558	197	221	59	218	3	594	40	3,146	41	12.85	2.47	5.20	0.67	36.0	6.9	0.98	.288	2.51	6.33
19	Craig Kimbrel C. Kimbrel	699	1,265	55	33	.625	0	2.21	0	0	373	691.2	387	170	187	57	267	31	546	11	2,749	62	16.46	3.47	4.74	0.74	46.0	9.7	0.95	.292	2.43	5.04
20	Tom Gordon T. Gordon	699	1,928	128	106	.547	200	3.76	18	4	118	1946.2	1,707	814	898	155	888	36	264	50	8,322	102	8.91	4.11	2.17	0.72	23.2	10.7	1.33	.292	4.15	7.89
21	Roger Clemens R. Clemens	697	4,672	352	180	.662	696	3.09	116	45	0	4877.2	4,129	1,674	1,847	362	1,563	157	0	63	20,048	143	8.62	2.88	2.99	0.67	23.3	7.8	1.17	.283	3.41	7.62
22	Billy Wagner B. Wagner	684	1,196	37	26	.587	0	2.02	0	0	346	747.1	470	168	188	59	244	22	565	21	2,957	32	14.40	2.94	4.90	0.71	40.4	8.3	0.96	.286	2.26	5.66
23	Jim Kaat J. Kaat	678	2,462	267	197	.575	575	3.23	176	30	6	4174.1	4,122	1,498	1,757	360	953	113	45	84	17,367	115	5.31	2.05	2.58	0.78	14.2	5.5	1.22	.279	3.79	8.89
24	David Robertson D. Robertson	677	1,154	57	27	.679	1	2.54	0	0	146	720.1	506	203	224	57	283	17	281	29	2,944	46	14.42	3.54	4.08	0.71	39.2	9.6	1.10	.313	2.80	6.32
25	Warren Spahn W. Spahn	676	2,583	354	219	.618	629	2.95	374	62	14	5047.1	4,570	1,652	1,855	408	1,355	37	40	52	20,642	71	4.61	2.42	1.91	0.73	12.5	6.6	1.17	.256	3.31	8.15