Nolan Ryan had the most games pitched when striking out 10+ batters, with 215 games.

Interpreted as:

most 10 or more stikeout regular-season games by a pitcher

	NAME	G	SO	W	L	W%	GS	ERA	CG	SHO	SV	IP	H	ER	R	HR	BB	HBP	GF	IBB	TBF	WP	K/9	BB/9	K/BB	HR/9	K%	BB%	WHIP	BABIP	RA	H/9
1	Nolan Ryan N. Ryan	215	2,547	132	54	.710	215	1.82	127	43	0	1806.2	1,027	366	429	72	827	48	0	25	7,208	91	12.69	4.12	3.08	0.36	35.3	11.5	1.03	.257	2.14	5.12
2	Randy Johnson R. Johnson	212	2,554	138	37	.789	211	2.02	69	27	0	1652.2	1,087	371	420	125	437	59	1	12	6,435	38	13.91	2.38	5.84	0.68	39.7	6.8	0.92	.295	2.29	5.92
3	Max Scherzer M. Scherzer	113	1,255	64	19	.771	113	2.04	9	4	0	795.1	489	180	193	78	144	24	0	3	3,024	18	14.20	1.63	8.72	0.88	41.5	4.8	0.80	.270	2.18	5.53
4	Roger Clemens R. Clemens	110	1,263	80	12	.870	110	1.53	47	22	0	894.2	566	152	165	38	187	17	0	4	3,405	19	12.71	1.88	6.75	0.38	37.1	5.5	0.84	.278	1.66	5.69
5	Pedro Martinez P. Martinez	108	1,243	67	19	.779	108	1.61	28	9	0	829.0	514	148	167	49	177	30	0	9	3,167	12	13.49	1.92	7.02	0.53	39.2	5.6	0.83	.279	1.81	5.58
6	Sandy Koufax S. Koufax	97	1,135	76	14	.844	97	1.64	74	17	0	868.2	502	158	179	56	240	4	0	15	3,337	25	11.76	2.49	4.73	0.58	34.0	7.2	0.85	.234	1.85	5.20
7	Curt Schilling C. Schilling	93	1,056	60	20	.750	93	2.36	26	7	0	720.0	514	189	198	69	110	9	0	4	2,758	13	13.20	1.38	9.60	0.86	38.3	4.0	0.87	.294	2.48	6.43
8	Chris Sale C. Sale	91	1,041	44	21	.677	91	1.81	7	1	0	647.0	406	130	143	43	118	30	0	2	2,471	16	14.48	1.64	8.82	0.60	42.1	4.8	0.81	.293	1.99	5.65
9	Steve Carlton S. Carlton	84	970	56	19	.747	84	2.06	52	11	0	715.0	526	164	186	37	240	6	0	24	2,868	31	12.21	3.02	4.04	0.47	33.8	8.4	1.07	.303	2.34	6.62
10	Sam McDowell S. McDowell	74	861	44	14	.759	74	1.71	44	11	0	636.1	380	121	147	22	267	14	1	10	2,537	20	12.18	3.78	3.22	0.31	33.9	10.5	1.02	.261	2.08	5.37
11	Bob Gibson B. Gibson	74	844	55	15	.786	74	1.62	62	17	0	677.0	460	122	147	28	154	17	0	14	2,627	12	11.22	2.05	5.48	0.37	32.1	5.9	0.91	.273	1.95	6.12
12	Justin Verlander J. Verlander	72	807	48	9	.842	72	1.85	8	5	0	507.0	315	104	113	47	89	11	0	3	1,921	14	14.33	1.58	9.07	0.83	42.0	4.6	0.80	.277	2.01	5.59
13	Tom Seaver T. Seaver	70	807	50	11	.820	70	1.56	46	17	0	619.0	372	107	114	40	137	8	0	11	2,345	10	11.73	1.99	5.89	0.58	34.4	5.8	0.82	.245	1.66	5.41
14	Clayton Kershaw C. Kershaw	68	767	47	9	.839	68	1.54	13	8	0	514.0	292	88	96	35	64	7	0	1	1,874	13	13.43	1.12	11.98	0.61	40.9	3.4	0.69	.257	1.68	5.11
15	Gerrit Cole G. Cole	62	708	35	7	.833	62	1.92	4	3	0	416.2	251	89	104	40	70	8	0	1	1,561	13	15.29	1.51	10.11	0.86	45.4	4.5	0.77	.287	2.25	5.42
16	Jacob deGrom J. deGrom	61	683	30	11	.732	61	1.88	1	1	0	412.0	253	86	99	35	81	2	0	4	1,550	10	14.92	1.77	8.43	0.76	44.1	5.2	0.81	.291	2.16	5.53
17	David Cone D. Cone	59	661	38	10	.792	59	2.20	14	9	0	458.2	312	112	125	36	137	15	0	6	1,818	23	12.97	2.69	4.82	0.71	36.4	7.5	0.98	.285	2.45	6.12
18	Mickey Lolich M. Lolich	54	613	35	11	.761	54	1.85	38	9	0	476.1	343	98	113	29	138	20	0	4	1,902	15	11.58	2.61	4.44	0.55	32.2	7.3	1.01	.285	2.14	6.48
19	Bert Blyleven B. Blyleven	52	585	33	14	.702	52	1.54	37	9	0	450.0	317	77	97	18	87	13	0	4	1,746	10	11.70	1.74	6.72	0.36	33.5	5.0	0.90	.287	1.94	6.34
20	Jim Bunning J. Bunning	51	553	31	7	.816	51	1.61	28	6	0	448.0	317	80	95	28	94	14	0	6	1,753	3	11.11	1.89	5.88	0.56	31.5	5.4	0.92	.272	1.91	6.37
21	Bob Feller B. Feller	51	588	42	7	.857	51	1.66	46	13	0	460.1	287	85	96	9	219	6	0		1,875	11	11.50	4.28	2.68	0.18	31.4	11.7	1.10	.264	1.88	5.61
22	Yu Darvish Y. Darvish	50	561	27	13	.675	50	1.90	1	1	0	349.2	213	74	77	33	79	8	0	1	1,333	12	14.44	2.03	7.10	0.85	42.1	5.9	0.84	.276	1.98	5.48
23	Johan Santana J. Santana	50	558	32	8	.800	50	1.92	3	2	0	365.2	223	78	81	38	68	5	0	0	1,379	8	13.73	1.67	8.21	0.94	40.5	4.9	0.80	.261	1.99	5.49
24	Corey Kluber C. Kluber	48	540	32	2	.941	48	1.61	5	1	0	363.1	219	65	73	28	54	12	0	2	1,353	5	13.38	1.34	10.00	0.69	39.9	4.0	0.75	.266	1.81	5.42
25	Stephen Strasburg S. Strasburg	47	524	32	6	.842	47	2.20	1	1	0	323.2	205	79	87	32	57	8	0	3	1,222	6	14.57	1.58	9.19	0.89	42.9	4.7	0.81	.288	2.42	5.70