Nolan Ryan had the most games pitched when striking out 2+ batters, with 752 games.

Interpreted as:

most 2 or more strikeout regular-season games by a pitcher

	NAME	G	SO	W	L	W%	GS	ERA	CG	SHO	SV	IP	H	ER	R	HR	BB	HBP	GF	IBB	TBF	WP	K/9	BB/9	K/BB	HR/9	K%	BB%	WHIP	BABIP	RA	H/9
1	Nolan Ryan N. Ryan	752	5,680	322	266	.548	737	2.97	222	61	2	5286.1	3,747	1,743	1,998	299	2,668	152	5	76	21,983	267	9.67	4.54	2.13	0.51	25.8	12.1	1.21	.262	3.40	6.38
2	Don Sutton D. Sutton	694	3,525	312	216	.591	685	3.00	177	58	1	4960.2	4,240	1,652	1,816	415	1,226	75	4	93	20,120	102	6.40	2.22	2.88	0.75	17.5	6.1	1.10	.257	3.29	7.69
3	Phil Niekro P. Niekro	684	3,245	300	228	.568	644	3.05	244	45	9	4931.1	4,375	1,669	1,937	422	1,606	109	24	76	20,421	203	5.92	2.93	2.02	0.77	15.9	7.9	1.21	.263	3.54	7.98
4	Roger Clemens R. Clemens	683	4,658	347	175	.665	683	3.07	116	45	0	4809.0	4,047	1,638	1,802	353	1,529	154	0	62	19,736	142	8.72	2.86	3.05	0.66	23.6	7.7	1.16	.283	3.37	7.57
5	Greg Maddux G. Maddux	675	3,321	335	198	.629	674	2.98	109	35	0	4659.2	4,267	1,542	1,741	324	895	126	0	163	18,851	67	6.41	1.73	3.71	0.63	17.6	4.7	1.11	.278	3.36	8.24
6	Steve Carlton S. Carlton	673	4,095	321	215	.599	665	3.02	251	54	1	4971.0	4,339	1,668	1,910	368	1,721	51	3	139	20,529	165	7.41	3.12	2.38	0.67	19.9	8.4	1.22	.278	3.46	7.86
7	Gaylord Perry G. Perry	667	3,472	295	223	.569	621	2.82	297	53	5	4980.0	4,410	1,560	1,816	356	1,248	96	17	141	20,211	135	6.27	2.26	2.78	0.64	17.2	6.2	1.14	.270	3.28	7.97
8	Walter Johnson W. Johnson	655	3,378	381	219	.635	590	1.59	491	105	14	5295.1	4,263		1,578	77	1,187	187	64		21,007	135	5.74	2.02	2.85	0.13	16.1	5.7	1.03	.259	2.68	7.25
9	Bert Blyleven B. Blyleven	642	3,669	281	226	.554	640	3.13	241	59	0	4756.1	4,315	1,654	1,842	391	1,253	144	0	64	19,484	103	6.94	2.37	2.93	0.74	18.8	6.4	1.17	.280	3.49	8.16
10	Tom Seaver T. Seaver	602	3,603	301	179	.627	602	2.68	228	60	0	4571.0	3,691	1,363	1,505	345	1,303	71	0	108	18,390	113	7.09	2.57	2.77	0.68	19.6	7.1	1.09	.256	2.96	7.27
11	Randy Johnson R. Johnson	597	4,863	302	156	.659	586	3.16	99	37	2	4069.1	3,241	1,431	1,613	396	1,451	188	4	36	16,725	107	10.76	3.21	3.35	0.88	29.1	8.7	1.15	.290	3.57	7.17
12	Tom Glavine T. Glavine	590	2,552	275	162	.629	590	3.25	52	23	0	3933.0	3,697	1,419	1,566	302	1,281	55	0	128	16,404	59	5.84	2.93	1.99	0.69	15.6	7.8	1.27	.278	3.58	8.46
13	Fergie Jenkins F. Jenkins	576	3,137	279	198	.585	547	3.14	260	49	1	4232.0	3,791	1,477	1,647	438	913	80	12	102	17,178	60	6.67	1.94	3.44	0.93	18.3	5.3	1.11	.266	3.50	8.06
14	Warren Spahn W. Spahn	575	2,482	328	176	.651	552	2.74	346	60	5	4533.0	3,978	1,379	1,545	344	1,196	31	18	44	18,402	61	4.93	2.37	2.08	0.68	13.5	6.5	1.14	.253	3.07	7.90
15	Jamie Moyer J. Moyer	560	2,350	241	159	.603	540	3.93	31	10	0	3518.0	3,490	1,537	1,660	425	958	128	3	50	14,794	50	6.01	2.45	2.45	1.09	15.9	6.5	1.26	.280	4.25	8.93
16	Frank Tanana F. Tanana	548	2,709	225	198	.532	538	3.42	137	34	0	3803.1	3,562	1,445	1,627	384	1,115	117	4	100	15,878	105	6.41	2.64	2.43	0.91	17.1	7.0	1.23	.275	3.85	8.43
17	John Smoltz J. Smoltz	538	2,973	203	142	.588	458	3.27	53	16	56	3200.0	2,793	1,162	1,257	260	936	53	68	80	13,131	137	8.36	2.63	3.18	0.73	22.6	7.1	1.17	.284	3.54	7.86
18	Charlie Hough C. Hough	538	2,191	182	160	.532	384	3.35	105	13	21	3143.0	2,596	1,170	1,351	302	1,266	146	86	33	13,156	142	6.27	3.63	1.73	0.86	16.7	9.6	1.23	.248	3.87	7.43
19	CC Sabathia	537	3,074	247	148	.625	536	3.64	37	12	0	3461.2	3,260	1,399	1,530	367	1,042	118	0	42	14,451	70	7.99	2.71	2.95	0.95	21.3	7.2	1.24	.294	3.98	8.48
20	Jim Kaat J. Kaat	537	2,321	247	159	.608	500	2.90	174	30	1	3716.2	3,518	1,199	1,417	295	807	93	13	61	15,278	102	5.62	1.95	2.88	0.71	15.2	5.3	1.16	.274	3.43	8.52
21	Zack Greinke Z. Greinke	535	2,943	221	138	.616	513	3.39	16	5	1	3238.2	3,004	1,221	1,310	351	715	72	3	23	13,189	93	8.18	1.99	4.12	0.98	22.3	5.4	1.15	.291	3.64	8.35
22	Tommy John T. John	528	2,117	231	153	.602	514	2.80	140	41	0	3693.0	3,475	1,148	1,331	216	944	71	4	80	15,130	139	5.16	2.30	2.24	0.53	14.0	6.2	1.20	.277	3.24	8.47
23	Justin Verlander J. Verlander	526	3,452	261	142	.648	526	3.24	26	9	0	3420.2	2,868	1,231	1,330	353	950	112	0	25	13,930	95	9.08	2.50	3.63	0.93	24.8	6.8	1.12	.278	3.50	7.55
24	Robin Roberts R. Roberts	517	2,259	260	181	.590	503	3.04	285	43	3	4044.1	3,760	1,364	1,508	408	764	50	9	57	16,379	26	5.03	1.70	2.96	0.91	13.8	4.7	1.12	.260	3.36	8.37
25	Dennis Eckersley D. Eckersley	516	2,094	168	109	.606	313	3.25	95	19	116	2551.1	2,307	922	994	259	589	61	167	69	10,457	22	7.39	2.08	3.56	0.91	20.0	5.6	1.14	.275	3.51	8.14