most 2021 games with different starting lineups

Jesse Orosco has appeared in the most career games, with 1,252 games.

Interpreted as:

most 2021 regular-season games with different starting by a player lineups

	NAME	G	GS	W	L	W%	ERA	SO	CG	SHO	SV	IP	H	ER	R	HR	BB	HBP	GF	IBB	TBF	WP	K/9	BB/9	K/BB	HR/9	K%	BB%	WHIP	BABIP	RA	ERA-	FIP	FIP-	H/9	PRAA
1	Jesse Orosco J. Orosco	1,252	4	87	80	.521	3.16	1,179	0	0	144	1295.1	1,055	455	512	113	581	34	501	86	5,460	40	8.19	4.04	2.03	0.79	21.6	10.6	1.26	.265	3.56	80	3.60	91	7.33	52.1
2	Mike Stanton M. Stanton	1,178	1	68	63	.519	3.92	895	0	0	84	1114.0	1,086	485	523	93	420	33	363	76	4,762	35	7.23	3.39	2.13	0.75	18.8	8.8	1.35	.299	4.23	90	3.74	86	8.77	77.6
3	John Franco J. Franco	1,119	0	90	87	.508	2.89	975	0	0	424	1245.2	1,166	400	466	81	495	22	774	78	5,312	54	7.04	3.58	1.97	0.59	18.4	9.3	1.33	.290	3.37	73	3.44	86	8.42	76
4	Mariano Rivera M. Rivera	1,115	10	82	60	.577	2.21	1,173	0	0	652	1283.2	998	315	340	71	286	46	952	41	5,103	13	8.22	2.01	4.10	0.50	23.0	5.6	1.00	.263	2.38	49	2.76	61	7.00	246.7
5	Dennis Eckersley D. Eckersley	1,071	361	197	171	.535	3.50	2,401	100	20	390	3285.2	3,076	1,278	1,382	347	738	75	577	91	13,534	28	6.58	2.02	3.25	0.95	17.7	5.5	1.16	.274	3.79	86	3.40	85	8.43	224.9
6	Hoyt Wilhelm H. Wilhelm	1,070	52	143	122	.540	2.52	1,610	20	5	228	2254.1	1,757	632	773	150	778	62	651	61	9,164	90	6.43	3.11	2.07	0.60	17.6	8.5	1.12	.245	3.09	68	3.06	82	7.01	167.6
7	Dan Plesac D. Plesac	1,064	14	65	71	.478	3.64	1,041	0	0	158	1072.0	977	433	478	105	402	17	422	54	4,539	41	8.74	3.38	2.59	0.88	22.9	8.9	1.29	.293	4.01	86	3.45	82	8.20	89.5
8	Mike Timlin M. Timlin	1,058	4	75	73	.507	3.63	872	0	0	141	1204.1	1,168	486	533	118	377	47	467	72	5,082	31	6.52	2.82	2.31	0.88	17.2	7.4	1.28	.286	3.98	81	3.93	89	8.73	65.9
9	Kent Tekulve K. Tekulve	1,050	0	94	90	.511	2.85	779	0	0	184	1436.2	1,305	455	526	63	491	17	638	179	6,001	23	4.88	3.08	1.59	0.39	13.0	8.2	1.25	.267	3.30	77	3.25	88	8.18	71.1
10	LaTroy Hawkins L. Hawkins	1,042	98	75	94	.444	4.31	983	2	0	127	1467.1	1,607	702	763	163	456	21	373	35	6,323	70	6.03	2.80	2.16	1.00	15.5	7.2	1.41	.307	4.68	94	4.17	94	9.86	38.8
11	Trevor Hoffman T. Hoffman	1,035	0	61	75	.449	2.87	1,133	0	0	601	1089.1	846	347	378	100	307	9	856	58	4,388	49	9.36	2.54	3.69	0.83	25.8	7.0	1.06	.263	3.12	71	3.07	73	6.99	143.1
12	Jose Mesa J. Mesa	1,022	95	80	109	.423	4.36	1,038	6	2	321	1548.2	1,629	750	811	151	651	55	633	57	6,804	75	6.03	3.78	1.59	0.88	15.3	9.6	1.47	.301	4.71	100	4.31	99	9.47	9.5
13	Lee Smith L. Smith	1,022	6	71	92	.436	3.03	1,251	0	0	478	1289.1	1,133	434	475	89	486	10	802	100	5,388	47	8.73	3.39	2.57	0.62	23.2	9.0	1.26	.294	3.32	76	2.92	74	7.91	142
14	Roberto Hernandez R. Hernandez	1,010	3	67	71	.486	3.45	945	0	0	326	1071.1	1,002	411	475	96	462	35	667	53	4,632	50	7.94	3.88	2.05	0.81	20.4	10.0	1.37	.293	3.99	77	3.85	86	8.42	74
15	Michael Jackson M. Jackson	1,005	7	62	67	.481	3.42	1,006	0	0	142	1188.1	983	451	492	127	464	56	422	80	4,966	39	7.62	3.51	2.17	0.96	20.3	9.3	1.22	.258	3.73	81	3.95	94	7.44	38.1
16	Rich Gossage R. Gossage	1,002	37	124	107	.537	3.01	1,502	16	0	310	1809.1	1,497	605	670	119	732	47	681	90	7,507	63	7.47	3.64	2.05	0.59	20.0	9.8	1.23	.270	3.33	81	3.18	84	7.45	125.4
17	Lindy McDaniel L. McDaniel	987	74	141	119	.542	3.45	1,361	18	2	174	2139.1	2,099	821	934	172	623	15	577	136	8,971	112	5.73	2.62	2.18	0.72	15.2	6.9	1.27	.283	3.93	92	3.19	86	8.83	123.8
18	Todd Jones T. Jones	982	1	58	63	.479	3.97	868	0	0	319	1072.0	1,072	473	518	93	443	38	619	62	4,650	43	7.29	3.72	1.96	0.78	18.7	9.5	1.41	.305	4.35	89	3.94	90	9.00	55.4
19	David Weathers D. Weathers	964	69	73	88	.453	4.25	976	0	0	75	1376.1	1,432	650	711	133	604	57	304	78	6,071	41	6.38	3.95	1.62	0.87	16.1	9.9	1.48	.302	4.65	99	4.37	100	9.36	2.6
20	Fernando Rodney F. Rodney	951	0	48	71	.403	3.80	943	0	0	327	933.0	817	394	433	73	464	52	590	38	4,064	65	9.10	4.48	2.03	0.70	23.2	11.4	1.37	.294	4.18	91	3.76	90	7.88	43.6
21	Francisco Rodriguez F. Rodriguez	948	0	52	53	.495	2.86	1,142	0	0	437	976.0	738	310	336	98	389	17	677	42	4,011	68	10.53	3.59	2.94	0.90	28.5	9.7	1.15	.271	3.10	69	3.30	79	6.81	97
22	Rollie Fingers R. Fingers	944	37	114	118	.491	2.90	1,299	4	2	341	1701.1	1,474	549	615	123	492	39	709	109	6,942	40	6.87	2.60	2.64	0.65	18.7	7.1	1.16	.271	3.25	83	2.95	82	7.80	125.4
23	Gene Garber G. Garber	931	9	96	113	.459	3.34	940	4	0	218	1510.0	1,464	560	654	123	445	37	609	155	6,327	30	5.60	2.65	2.11	0.73	14.9	7.0	1.26	.280	3.90	86	3.44	90	8.73	63.2
24	Eddie Guardado E. Guardado	908	25	46	61	.430	4.31	798	0	0	187	944.2	894	452	476	138	348	16	401	39	4,011	25	7.60	3.32	2.29	1.31	19.9	8.7	1.31	.279	4.53	92	4.44	98	8.52	7
25	Cy Young C. Young	906	815	511	316	.618	2.63	2,803	749	76	17	7356.0	7,092	2,147	3,167	138	1,217	161	84		29,565	156	3.43	1.49	2.30	0.17	9.5	4.1	1.13	.275	3.87	74	2.84	79	8.68	620