Nolan Ryan had the most games pitched when striking out 3+ batters, with 710 games.

Interpreted as:

most 3 or more strikeout regular-season games by a pitcher

	NAME	G	SO	W	L	W%	GS	ERA	CG	SHO	SV	IP	H	ER	R	HR	BB	HBP	GF	IBB	TBF	WP	K/9	BB/9	K/BB	HR/9	K%	BB%	WHIP	BABIP	RA	H/9
1	Nolan Ryan N. Ryan	710	5,596	316	247	.561	700	2.87	222	61	1	5117.2	3,576	1,632	1,869	286	2,551	139	4	71	21,187	260	9.84	4.49	2.19	0.50	26.4	12.0	1.20	.261	3.29	6.29
2	Roger Clemens R. Clemens	652	4,596	339	163	.675	652	2.99	116	45	0	4634.1	3,861	1,539	1,692	335	1,449	144	0	60	18,960	130	8.93	2.81	3.17	0.65	24.2	7.6	1.15	.284	3.29	7.50
3	Steve Carlton S. Carlton	612	3,973	309	189	.620	608	2.89	245	51	1	4641.0	3,939	1,488	1,692	323	1,602	46	3	132	19,050	158	7.70	3.11	2.48	0.63	20.9	8.4	1.19	.276	3.28	7.64
4	Don Sutton D. Sutton	604	3,345	284	179	.613	598	2.78	169	54	1	4445.1	3,655	1,372	1,517	352	1,084	65	2	84	17,883	96	6.77	2.19	3.09	0.71	18.7	6.1	1.07	.253	3.07	7.40
5	Greg Maddux G. Maddux	591	3,153	302	165	.647	590	2.80	106	34	0	4175.2	3,712	1,297	1,461	274	783	111	0	141	16,773	58	6.80	1.69	4.03	0.59	18.8	4.7	1.08	.276	3.15	8.00
6	Bert Blyleven B. Blyleven	585	3,555	266	197	.575	584	3.00	235	58	0	4419.1	3,936	1,475	1,646	349	1,155	133	0	57	18,027	94	7.24	2.35	3.08	0.71	19.7	6.4	1.15	.279	3.35	8.02
7	Gaylord Perry G. Perry	577	3,292	274	188	.593	550	2.62	282	49	5	4492.1	3,859	1,310	1,539	310	1,104	82	11	123	18,092	115	6.60	2.21	2.98	0.62	18.2	6.1	1.10	.267	3.08	7.73
8	Phil Niekro P. Niekro	575	3,027	266	187	.587	558	2.92	229	40	5	4322.0	3,756	1,401	1,641	356	1,391	98	13	65	17,822	181	6.30	2.90	2.18	0.74	17.0	7.8	1.19	.263	3.42	7.82
9	Randy Johnson R. Johnson	571	4,811	297	144	.673	561	3.02	99	37	2	3963.2	3,110	1,329	1,503	376	1,370	178	4	35	16,200	98	10.92	3.11	3.51	0.85	29.7	8.5	1.13	.289	3.41	7.06
10	Walter Johnson W. Johnson	553	3,174	343	179	.657	518	1.39	453	101	4	4717.2	3,688		1,305	67	1,020	162	34		18,579	125	6.06	1.95	3.11	0.13	17.1	5.5	1.00	.256	2.49	7.04
11	Tom Seaver T. Seaver	550	3,499	285	159	.642	550	2.53	221	58	0	4250.2	3,364	1,193	1,319	317	1,195	62	0	97	17,020	105	7.41	2.53	2.93	0.67	20.6	7.0	1.07	.255	2.79	7.12
12	Fergie Jenkins F. Jenkins	505	2,995	263	169	.609	489	2.94	247	47	1	3865.2	3,381	1,263	1,416	398	805	75	6	91	15,599	53	6.97	1.87	3.72	0.93	19.2	5.2	1.08	.263	3.30	7.87
13	Justin Verlander J. Verlander	498	3,396	257	126	.671	498	3.04	26	9	0	3276.1	2,665	1,107	1,199	325	889	107	0	24	13,257	90	9.33	2.44	3.82	0.89	25.6	6.7	1.08	.274	3.29	7.32
14	CC Sabathia	493	2,986	232	134	.634	493	3.48	37	12	0	3224.1	2,982	1,247	1,367	331	950	109	0	38	13,382	64	8.33	2.65	3.14	0.92	22.3	7.1	1.22	.294	3.82	8.32
15	Zack Greinke Z. Greinke	479	2,831	212	122	.635	470	3.20	14	4	0	2989.1	2,691	1,062	1,145	308	646	68	0	21	12,096	90	8.52	1.94	4.38	0.93	23.4	5.3	1.12	.289	3.45	8.10
16	Tom Glavine T. Glavine	478	2,328	235	124	.655	478	2.97	45	19	0	3259.0	2,989	1,077	1,200	229	1,031	37	0	98	13,502	47	6.43	2.85	2.26	0.63	17.2	7.6	1.23	.279	3.31	8.25
17	Frank Tanana F. Tanana	463	2,539	202	164	.552	456	3.20	129	34	0	3319.1	3,007	1,180	1,334	318	946	96	3	85	13,736	87	6.88	2.56	2.68	0.86	18.5	6.9	1.19	.273	3.62	8.15
18	Mike Mussina M. Mussina	453	2,696	247	112	.688	453	3.29	56	23	0	3123.2	2,841	1,143	1,224	304	648	54	0	25	12,597	60	7.77	1.87	4.16	0.88	21.4	5.1	1.12	.285	3.53	8.19
19	Warren Spahn W. Spahn	452	2,236	283	130	.685	445	2.51	308	51	0	3747.1	3,155	1,047	1,175	281	961	23	6	34	15,067	49	5.37	2.31	2.33	0.67	14.8	6.4	1.10	.248	2.82	7.58
20	John Smoltz J. Smoltz	450	2,797	193	130	.598	426	3.08	52	16	19	2968.1	2,544	1,016	1,108	231	852	44	22	75	12,113	128	8.48	2.58	3.28	0.70	23.1	7.0	1.14	.282	3.36	7.71
21	Jim Bunning J. Bunning	443	2,684	208	131	.614	427	2.77	146	39	3	3264.1	2,765	1,006	1,135	304	838	136	8	79	13,318	37	7.40	2.31	3.20	0.84	20.2	6.3	1.10	.263	3.13	7.62
22	Jamie Moyer J. Moyer	442	2,114	207	117	.639	430	3.51	29	9	0	2897.2	2,703	1,131	1,226	300	755	102	1	39	11,997	40	6.57	2.34	2.80	0.93	17.6	6.3	1.19	.275	3.81	8.40
23	Bob Gibson B. Gibson	441	3,017	239	144	.624	429	2.67	247	55	2	3544.2	2,903	1,050	1,195	221	1,143	97	5	101	14,524	95	7.66	2.90	2.64	0.56	20.8	7.9	1.14	.267	3.03	7.37
24	Andy Pettitte A. Pettitte	440	2,321	229	115	.666	439	3.51	25	4	0	2885.0	2,857	1,124	1,238	239	841	46	0	32	12,062	58	7.24	2.62	2.76	0.75	19.2	7.0	1.28	.304	3.86	8.91
25	Bartolo Colon B. Colon	439	2,356	212	133	.614	434	3.74	31	11	0	2830.1	2,782	1,175	1,262	333	764	47	0	37	11,816	35	7.49	2.43	3.08	1.06	19.9	6.5	1.25	.294	4.01	8.85