Walter Johnson has the most career at-bats by a starting pitcher, with 2,045 at-bats.

	NAME	AB	G	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Walter Johnson W. Johnson	2,045	666	209	481	86	37	22		95	10		12		2,220	707	145	70				.235	.273	.346	.618
2	Warren Spahn W. Spahn	1,825	665	137	357	57	6	33	183	95	7	479	4	1	2,008	525	96	67	14	0	22	.196	.236	.288	.524
3	Grover Alexander G. Alexander	1,751	600	149	368	58	13	11		75	2	262	3		1,918	485	82	90				.210	.243	.277	.520
4	Steve Carlton S. Carlton	1,717	677	120	346	49	6	13	140	40	10	411	2	2	1,874	446	68	94	13	0	34	.202	.222	.260	.482
5	Red Ruffing R. Ruffing	1,631	538	190	442	84	11	32	217	74	6	211	1		1,748	644	127	37			11	.271	.305	.395	.700
6	Christy Mathewson C. Mathewson	1,591	551	141	337	43	12	7		112	15		21		1,780	425	62	62				.212	.270	.267	.537
7	Greg Maddux G. Maddux	1,587	718	100	271	35	2	5	84	34	5	418	11	2	1,805	325	42	177	2	0	15	.171	.190	.205	.395
8	Early Wynn E. Wynn	1,572	611	127	339	53	4	15	150	120	2	298	1	0	1,748	445	72	50	4	0	32	.216	.271	.283	.555
9	Eddie Plank E. Plank	1,507	529	122	312	35	6	3		63	24		12		1,665	368	44	71				.207	.250	.244	.495
10	Phil Niekro P. Niekro	1,503	595	79	257	40	1	7	109	16	12	298	0	1	1,666	320	48	123	12	0	35	.171	.185	.213	.398
11	Robin Roberts R. Roberts	1,492	609	105	252	55	9	5	103	132	8	358	3	1	1,747	340	69	109	6	0	31	.169	.239	.228	.467
12	Ted Lyons T. Lyons	1,452	484	134	340	46	9	5	137	65	6	183	0		1,605	419	60	82			9	.234	.270	.289	.558
13	Eppa Rixey E. Rixey	1,440	554	92	280	33	4	3		49	9	206	2		1,580	330	40	82				.194	.226	.229	.455
14	Burleigh Grimes B. Grimes	1,434	496	144	358	58	11	2	159	67	4	217	15		1,574	444	71	69				.250	.285	.310	.595
15	Don Sutton D. Sutton	1,349	583	58	193	15	1	0	63	60	6	364	1	0	1,554	210	16	136	3	0	29	.143	.183	.156	.338
16	Tom Seaver T. Seaver	1,312	554	95	202	28	5	12	86	108	4	484	4	0	1,548	276	45	120	4	0	22	.154	.220	.210	.430
17	Tom Glavine T. Glavine	1,310	661	90	244	25	2	1	90	99	2	326	1	0	1,629	276	28	215	3	0	13	.186	.244	.211	.455
18	George Mullin G. Mullin	1,306	425	147	354	63	22	3		113	7		17		1,442	470	88	20				.271		.360
19	Bob Gibson B. Gibson	1,298	482	118	269	43	5	24	140	59	8	403	13	10	1,452	394	72	70	17	0	13	.207	.243	.304	.547
20	Bobo Newsom B. Newsom	1,281	483	79	242	27	3	1	97	16	1	254	1	0	1,381	278	31	83			28	.189	.200	.217	.417
21	Bob Feller B. Feller	1,263	484	98	190	28	13	8	98	95	3	499	1	1	1,459	268	49	98	0	0	15	.150	.212	.212	.424
22	Lefty Grove L. Grove	1,261	457	112	189	21	5	14	113	99	2	549	1		1,460	262	40	98			1	.150	.213	.208	.421
23	Earl Whitehill E. Whitehill	1,260	473	102	256	23	7	4	97	97	1	207	3		1,412	305	34	54			1	.203	.261	.242	.503
24	Jim Bunning J. Bunning	1,243	519	75	202	19	4	6	73	33	1	351	0	2	1,367	247	29	84	6	0	33	.163	.184	.199	.383
25	Carl Hubbell C. Hubbell	1,216	433	91	229	29	1	4	96	30	1	162	1		1,320	272	34	73			6	.188	.209	.224	.432