Before 1946, Firpo Marberry had the most saves, with 99 saves.

Interpreted as:

most career regular-season saves by a player through 1945

	NAME	SV	G	W	L	W%	GS	ERA	SO	CG	SHO	IP	H	ER	R	HR	BB	HBP	GF	TBF	WP	K/9	BB/9	K/BB	HR/9	K%	BB%	WHIP	BABIP	RA	ERA-	FIP	FIP-	H/9	PRAA
1	Firpo Marberry F. Marberry	99	551	148	88	.627	186	3.63	822	86	7	2067.1	2,049	834	971	96	686	38	272	8,759	14	3.58	2.99	1.20	0.42	9.4	7.8	1.32	.274	4.23	86	3.92	94	8.92	55
2	Johnny Murphy J. Murphy	97	356	89	51	.636	40	3.54	350	17	0	945.1	904	372	425	47	397	5	253	4,048	12	3.33	3.78	0.88	0.45	8.6	9.8	1.38	.264	4.05	84	4.12	100	8.61	-4.1
3	Joe Heving J. Heving	65	430	76	48	.613	40	3.90	429	17	3	1038.2	1,136	450	559	64	380	24	232	4,579	14	3.72	3.29	1.13	0.55	9.4	8.3	1.46	.291	4.84	92	4.01	98	9.84	12.2
4	Clint Brown C. Brown	64	434	89	93	.489	130	4.26	410	62	8	1485.2	1,740	704	830	86	368	20	250	6,495	18	2.48	2.23	1.11	0.52	6.3	5.7	1.42	.295	5.03	93	4.05	90	10.54	73.8
5	Jack Quinn J. Quinn	56	756	247	218	.531	443	3.29	1,329	243	28	3920.1	4,238	1,433	1,837	103	860	91	218	16,356	62	3.05	1.97	1.55	0.24	8.1	5.3	1.30	.296	4.22	89	3.17	87	9.73	217.4
6	Lefty Grove L. Grove	54	616	300	141	.680	457	3.06	2,266	298	35	3940.2	3,849	1,339	1,594	162	1,187	42	123	16,622	51	5.18	2.71	1.91	0.37	13.6	7.1	1.28	.284	3.64	68	3.36	76	8.79	462.8
7	Waite Hoyt W. Hoyt	53	674	237	182	.566	425	3.59	1,206	226	26	3762.1	4,037	1,500	1,780	154	1,003	49	172	16,010	39	2.88	2.40	1.20	0.37	7.5	6.3	1.34	.286	4.26	89	3.76	93	9.66	103.9
8	Ace Adams A. Adams	49	299	41	32	.562	7	3.40	168	2	0	550.0	532	208	242	24	223	8	216	2,360	15	2.75	3.65	0.75	0.39	7.1	9.4	1.37	.262	3.96	94	3.72	103	8.71	-5.9
9	Wilcy Moore W. Moore	49	261	51	44	.537	32	3.70	204	14	2	691.0	732	284	356	25	232	3	161	3,025	14	2.66	3.02	0.88	0.33	6.7	7.7	1.40	.276	4.64	89	3.93	97	9.53	6.7
10	Mordecai Brown M. Brown	49	481	239	130	.648	332	2.06	1,375	271	55	3172.1	2,708	725	1,044	43	673	61	138	12,422	61	3.90	1.91	2.04	0.12	11.1	5.4	1.07	.259	2.96	71	2.42	83	7.68	161.9
11	Mace Brown M. Brown	47	369	73	56	.566	55	3.50	425	18	2	1049.0	1,099	408	495	42	372	7	200	4,520	26	3.65	3.19	1.14	0.36	9.4	8.2	1.40	.288	4.25	91	3.70	94	9.43	30.6
12	Syl Johnson S. Johnson	43	542	112	117	.489	209	4.06	920	82	11	2165.2	2,290	977	1,099	172	488	48	206	9,124	22	3.82	2.03	1.89	0.71	10.1	5.3	1.28	.283	4.57	96	4.00	93	9.52	79.1
13	Charlie Root C. Root	42	632	201	160	.557	341	3.59	1,459	177	21	3197.1	3,252	1,274	1,467	189	889	79	186	13,529	22	4.11	2.50	1.64	0.53	10.8	6.6	1.30	.281	4.13	91	3.79	94	9.15	86.7
14	Allen Russell A. Russell	42	345	70	76	.479	112	3.52	603	54	5	1394.1	1,382	545	693	58	610	44	154	5,939	28	3.89	3.94	0.99	0.37	10.2	10.3	1.43	.286	4.47	101	3.77	109	8.92	-52.3
15	Bob Smith B. Smith	41	435	106	139	.433	229	3.94	618	128	16	2246.1	2,472	983	1,139	132	670	18	157	9,651	11	2.48	2.68	0.92	0.53	6.4	6.9	1.40	.285	4.56	101	4.22	106	9.90	-74
16	Hooks Dauss H. Dauss	41	538	223	182	.551	388	3.30	1,201	245	22	3390.2	3,407	1,245	1,594	87	1,067	121	120	14,175	48	3.19	2.83	1.13	0.23	8.5	7.5	1.32	.284	4.23	97	3.33	97	9.04	43.7
17	Jack Russell J. Russell	39	557	85	141	.376	182	4.46	418	71	3	2050.2	2,454	1,017	1,187	83	571	26	209	9,020	22	1.83	2.51	0.73	0.36	4.6	6.3	1.48	.299	5.21	104	4.07	96	10.77	34.5
18	Dick Coffman D. Coffman	38	472	72	95	.431	132	4.65	372	47	8	1460.1	1,782	755	894	92	463	35	194	6,526	17	2.29	2.85	0.80	0.57	5.7	7.1	1.54	.304	5.51	106	4.42	101	10.98	0
19	Herb Pennock H. Pennock	37	617	241	162	.598	419	3.60	1,227	249	35	3571.2	3,900	1,428	1,699	128	916	36	135	15,096	65	3.09	2.31	1.34	0.32	8.1	6.1	1.35	.295	4.28	95	3.50	93	9.83	113.6
20	George Caster G. Caster	36	350	74	99	.428	127	4.51	576	62	6	1336.1	1,427	669	807	120	573	24	150	5,911	15	3.88	3.86	1.01	0.81	9.7	9.7	1.50	.283	5.44	103	4.47	105	9.61	-27.6
21	Slim Sallee S. Sallee	36	476	174	143	.549	305	2.56	836	189	25	2821.2	2,729	804	1,092	68	573	43	123	11,476	12	2.67	1.83	1.46	0.22	7.3	5.0	1.17	.267	3.48	89	2.87	97	8.70	25.8
22	Red Ames R. Ames	36	533	183	167	.523	371	2.63	1,702	209	27	3198.0	2,896	934	1,313	41	1,034	64	118	13,080	156	4.79	2.91	1.65	0.12	13.0	7.9	1.23	.279	3.70	93	2.54	88	8.15	121.5
23	Al Benton A. Benton	35	261	62	61	.504	127	3.72	499	44	7	1134.0	1,138	469	575	67	480	10	95	4,961	25	3.96	3.81	1.04	0.53	10.1	9.7	1.43	.274	4.56	85	3.94	93	9.03	37.7
24	Ed Walsh E. Walsh	35	430	195	126	.607	315	1.82	1,736	250	57	2964.1	2,346	598	873	23	617	52	105	11,413	76	5.27	1.87	2.81	0.07	15.2	5.4	1.00	.259	2.65	69	2.02	79	7.12	164.3
25	Guy Bush G. Bush	34	542	176	136	.564	308	3.86	850	151	16	2722.0	2,950	1,166	1,366	151	859	41	146	11,750	51	2.81	2.84	0.99	0.50	7.2	7.3	1.40	.284	4.52	96	4.16	102	9.75	-33.5