Before 2006, Reggie Jackson had the most strikeouts, with 2,597 strikeouts.

Interpreted as:

most career strikeouts by a player through 2005

	NAME	SO	G	AB	R	H	2B	3B	HR	RBI	BB	HBP	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS	WRC	WRAA	WOBA	WRC+	BRAA
1	Reggie Jackson R. Jackson	2,597	2,820	9,864	1,551	2,584	463	49	563	1,702	1,375	96	228	115	11,416	4,834	1,075	13	68	164	183	.262	.356	.490	.846	1749	503	.374	139	497.6
2	Sammy Sosa S. Sosa	2,194	2,240	8,401	1,422	2,304	355	44	588	1,575	895	56	234	107	9,442	4,511	987	17	73	151	191	.274	.345	.537	.882	1502	344.6	.372	125	309.3
3	Andres Galarraga A. Galarraga	2,003	2,257	8,096	1,195	2,333	444	32	399	1,425	583	178	128	81	8,916	4,038	875	1	58	106	179	.288	.347	.499	.846	1355	286.5	.365	118	193.8
4	Jose Canseco J. Canseco	1,942	1,887	7,057	1,186	1,877	340	14	462	1,407	906	84	200	88	8,129	3,631	816	1	81	63	178	.266	.353	.515	.867	1293	321.2	.375	130	300.8
5	Willie Stargell W. Stargell	1,936	2,360	7,927	1,194	2,232	423	55	475	1,540	937	78	17	16	9,026	4,190	953	9	75	227	143	.282	.360	.529	.889	1471	511.5	.387	145	459.3
6	Mike Schmidt M. Schmidt	1,883	2,404	8,352	1,506	2,234	408	59	548	1,595	1,507	79	174	92	10,062	4,404	1,015	16	108	201	156	.267	.380	.527	.908	1717	591	.395	147	539.8
7	Fred McGriff F. McGriff	1,882	2,460	8,757	1,349	2,490	441	24	493	1,550	1,305	39	72	38	10,174	4,458	958	2	71	171	226	.284	.377	.509	.886	1678	454.1	.383	134	415.9
8	Tony Perez T. Perez	1,867	2,777	9,778	1,272	2,732	505	79	379	1,652	925	43	49	33	10,861	4,532	963	9	106	150	268	.279	.341	.463	.804	1511	343.8	.356	121	265.2
9	Dave Kingman D. Kingman	1,816	1,941	6,677	901	1,575	240	25	442	1,210	608	53	85	49	7,429	3,191	707	16	75	72	139	.236	.302	.478	.780	960	139.8	.343	113	108.5
10	Jim Thome J. Thome	1,762	1,738	5,919	1,151	1,665	324	24	430	1,193	1,257	50	18	19	7,281	3,327	778	1	54	127	106	.281	.408	.562	.970	1395	488.1	.411	147	443.6
11	Bobby Bonds B. Bonds	1,757	1,849	7,043	1,258	1,886	302	66	332	1,024	914	53	461	169	8,090	3,316	700	16	64	75	107	.268	.353	.471	.824	1192	318.7	.368	130	274.9
12	Dale Murphy D. Murphy	1,748	2,180	7,960	1,197	2,111	350	39	398	1,266	986	28	161	68	9,040	3,733	787	6	60	159	209	.265	.346	.469	.815	1291	273.7	.357	119	202.4
13	Lou Brock L. Brock	1,730	2,616	10,332	1,610	3,023	486	141	149	900	761	49	938	307	11,235	4,238	776	47	46	124	114	.293	.343	.410	.753	1406	210.2	.336	109	113.1
14	Mickey Mantle M. Mantle	1,710	2,401	8,102	1,676	2,415	344	72	536	1,509	1,733	13	153	38	9,909	4,511	952	14	47	126	113	.298	.421	.557	.977	1941	840	.428	170	821.8
15	Harmon Killebrew H. Killebrew	1,699	2,435	8,147	1,283	2,086	290	24	573	1,584	1,559	48	19	18	9,831	4,143	887	0	77	160	243	.256	.376	.509	.884	1630	569	.389	142	477.8
16	Chili Davis C. Davis	1,698	2,435	8,673	1,240	2,380	424	30	350	1,372	1,194	15	142	98	9,996	3,914	804	20	94	188	232	.274	.360	.451	.811	1420	249.9	.354	118	225.1
17	Dwight Evans D. Evans	1,697	2,606	8,996	1,470	2,446	483	73	385	1,384	1,391	53	78	59	10,569	4,230	941	52	77	60	227	.272	.370	.470	.840	1640	459.6	.375	129	357.7
18	Rickey Henderson R. Henderson	1,694	3,081	10,961	2,295	3,055	510	66	297	1,115	2,190	98	1,406	335	13,346	4,588	873	30	67	61	172	.279	.401	.419	.820	2074	509.6	.372	132	507.9
19	Dave Winfield D. Winfield	1,686	2,973	11,003	1,669	3,110	540	88	465	1,833	1,216	25	223	96	12,358	5,221	1,093	19	95	172	319	.283	.353	.475	.827	1811	416.2	.364	128	400.6
20	Gary Gaetti G. Gaetti	1,602	2,507	8,951	1,130	2,280	443	39	360	1,341	634	96	96	65	9,817	3,881	842	32	104	57	236	.255	.308	.434	.741	1161	12.7	.325	95	-58
21	Mark McGwire M. McGwire	1,596	1,874	6,187	1,167	1,626	252	6	583	1,414	1,317	75	12	8	7,660	3,639	841	3	78	150	147	.263	.394	.588	.982	1480	564.9	.415	157	558.2
22	Lee May L. May	1,570	2,071	7,609	959	2,031	340	31	354	1,244	487	49	39	35	8,219	3,495	725	9	65	85	219	.267	.313	.459	.772	1053	174.1	.343	116	143.5
23	Jeff Bagwell J. Bagwell	1,558	2,150	7,797	1,517	2,314	488	32	449	1,529	1,401	128	202	78	9,431	4,213	969	3	102	155	221	.297	.408	.540	.948	1755	596.6	.405	149	588.3
24	Craig Biggio C. Biggio	1,557	2,564	9,811	1,697	2,795	604	52	260	1,063	1,097	273	407	119	11,341	4,283	916	89	71	67	130	.285	.370	.437	.807	1651	276.9	.357	119	272.1
25	Dick Allen D. Allen	1,556	1,749	6,332	1,099	1,848	320	79	351	1,119	894	16	133	52	7,314	3,379	750	19	53	138	164	.292	.378	.534	.912	1258	491.7	.400	155	443.3