| NAME | CG | G | W | L | W% | GS | ERA | SO | SHO | SV | IP | H | ER | R | HR | BB | HBP | GF | IBB | TBF | WP | K/9 | BB/9 | K/BB | HR/9 | K% | BB% | WHIP | BABIP | RA | ERA- | FIP | FIP- | H/9 | PRAA | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | R. Halladay | 65 | 359 | 190 | 91 | .676 | 357 | 3.17 | 1,978 | 19 | 0 | 2518.1 | 2,374 | 886 | 968 | 201 | 469 | 75 | 0 | 27 | 10,217 | 44 | 7.07 | 1.68 | 4.22 | 0.72 | 19.4 | 4.6 | 1.13 | .290 | 3.46 | 73 | 3.19 | 74 | 8.48 | 317 | |
| 2 | CC Sabathia | 38 | 561 | 251 | 161 | .609 | 560 | 3.74 | 3,093 | 12 | 0 | 3577.1 | 3,404 | 1,485 | 1,623 | 382 | 1,099 | 123 | 0 | 44 | 14,989 | 74 | 7.78 | 2.76 | 2.81 | 0.96 | 20.6 | 7.3 | 1.26 | .294 | 4.08 | 87 | 3.77 | 87 | 8.56 | 223.7 | |
| 3 | L. Hernandez | 34 | 405 | 134 | 139 | .491 | 361 | 4.52 | 1,431 | 7 | 1 | 2415.2 | 2,695 | 1,212 | 1,290 | 275 | 773 | 63 | 17 | 69 | 10,442 | 32 | 5.33 | 2.88 | 1.85 | 1.02 | 13.7 | 7.4 | 1.44 | .306 | 4.81 | 107 | 4.40 | 104 | 10.04 | -44.7 | |
| 4 | M. Buehrle | 33 | 490 | 210 | 159 | .569 | 490 | 3.81 | 1,833 | 10 | 0 | 3232.0 | 3,417 | 1,367 | 1,515 | 356 | 715 | 76 | 0 | 48 | 13,480 | 27 | 5.10 | 1.99 | 2.56 | 0.99 | 13.6 | 5.3 | 1.28 | .292 | 4.22 | 87 | 4.10 | 93 | 9.52 | 107.8 | |
| 5 | C. Lee | 29 | 328 | 143 | 91 | .611 | 324 | 3.52 | 1,824 | 12 | 0 | 2156.2 | 2,116 | 843 | 923 | 223 | 464 | 50 | 1 | 12 | 8,917 | 41 | 7.61 | 1.94 | 3.93 | 0.93 | 20.5 | 5.2 | 1.20 | .298 | 3.85 | 84 | 3.44 | 82 | 8.83 | 168.2 | |
| 6 | A. Wainwright | 28 | 478 | 200 | 128 | .610 | 411 | 3.53 | 2,202 | 11 | 3 | 2668.1 | 2,577 | 1,047 | 1,117 | 233 | 736 | 81 | 13 | 40 | 11,116 | 51 | 7.43 | 2.48 | 2.99 | 0.79 | 19.8 | 6.6 | 1.24 | .298 | 3.77 | 88 | 3.53 | 87 | 8.69 | 152.8 | |
| 7 | B. Colon | 28 | 453 | 196 | 159 | .552 | 442 | 4.13 | 1,938 | 9 | 0 | 2770.2 | 2,933 | 1,270 | 1,379 | 367 | 650 | 47 | 2 | 32 | 11,680 | 28 | 6.30 | 2.11 | 2.98 | 1.19 | 16.6 | 5.6 | 1.29 | .296 | 4.48 | 98 | 4.15 | 98 | 9.53 | 24.7 | |
| 8 | J. Verlander | 26 | 555 | 266 | 158 | .627 | 555 | 3.32 | 3,553 | 9 | 0 | 3567.2 | 3,046 | 1,317 | 1,428 | 371 | 1,004 | 121 | 0 | 28 | 14,607 | 99 | 8.96 | 2.53 | 3.54 | 0.94 | 24.3 | 6.9 | 1.14 | .280 | 3.60 | 79 | 3.43 | 81 | 7.68 | 310.9 | |
| 9 | C. Kershaw | 25 | 455 | 223 | 96 | .699 | 451 | 2.53 | 3,052 | 15 | 0 | 2855.1 | 2,193 | 804 | 881 | 235 | 713 | 46 | 1 | 28 | 11,279 | 108 | 9.62 | 2.25 | 4.28 | 0.74 | 27.1 | 6.3 | 1.02 | .271 | 2.78 | 65 | 2.85 | 70 | 6.91 | 375.1 | |
| 10 | F. Hernandez | 25 | 419 | 169 | 136 | .554 | 418 | 3.42 | 2,524 | 11 | 0 | 2729.2 | 2,487 | 1,037 | 1,157 | 264 | 805 | 105 | 0 | 16 | 11,284 | 156 | 8.32 | 2.65 | 3.14 | 0.87 | 22.4 | 7.1 | 1.21 | .293 | 3.81 | 84 | 3.52 | 85 | 8.20 | 181.5 | |
| 11 | C. Carpenter | 25 | 245 | 110 | 60 | .647 | 244 | 3.30 | 1,287 | 12 | 0 | 1637.2 | 1,539 | 601 | 658 | 149 | 398 | 70 | 0 | 20 | 6,731 | 27 | 7.07 | 2.19 | 3.23 | 0.82 | 19.1 | 5.9 | 1.18 | .288 | 3.62 | 80 | 3.52 | 84 | 8.46 | 118.1 | |
| 12 | M. Mulder | 25 | 178 | 94 | 50 | .653 | 176 | 4.02 | 746 | 10 | 0 | 1160.0 | 1,161 | 518 | 551 | 119 | 343 | 46 | 1 | 12 | 4,857 | 41 | 5.79 | 2.66 | 2.17 | 0.92 | 15.4 | 7.1 | 1.30 | .289 | 4.27 | 92 | 4.08 | 93 | 9.01 | 40 | |
| 13 | A.J. Burnett | 24 | 415 | 157 | 148 | .515 | 410 | 3.97 | 2,423 | 10 | 0 | 2607.1 | 2,402 | 1,150 | 1,259 | 252 | 1,031 | 141 | 1 | 30 | 11,119 | 159 | 8.36 | 3.56 | 2.35 | 0.87 | 21.8 | 9.3 | 1.32 | .296 | 4.35 | 97 | 3.82 | 92 | 8.29 | 97.4 | |
| 14 | R. Johnson | 24 | 252 | 124 | 71 | .636 | 246 | 3.44 | 1,835 | 9 | 0 | 1636.2 | 1,414 | 626 | 701 | 189 | 408 | 83 | 3 | 21 | 6,685 | 29 | 10.09 | 2.24 | 4.50 | 1.04 | 27.4 | 6.1 | 1.11 | .294 | 3.85 | 78 | 3.21 | 73 | 7.78 | 214.2 | |
| 15 | J. Shields | 23 | 407 | 145 | 139 | .511 | 405 | 4.01 | 2,234 | 9 | 0 | 2616.0 | 2,581 | 1,167 | 1,267 | 361 | 746 | 97 | 1 | 22 | 10,993 | 107 | 7.69 | 2.57 | 2.99 | 1.24 | 20.3 | 6.8 | 1.27 | .294 | 4.36 | 98 | 4.16 | 101 | 8.88 | -13.5 | |
| 16 | T. Hudson | 23 | 429 | 191 | 125 | .604 | 426 | 3.46 | 1,779 | 11 | 0 | 2788.0 | 2,667 | 1,071 | 1,163 | 216 | 773 | 113 | 0 | 77 | 11,578 | 71 | 5.74 | 2.50 | 2.30 | 0.70 | 15.4 | 6.7 | 1.23 | .282 | 3.75 | 84 | 3.76 | 91 | 8.61 | 121 | |
| 17 | J. Vazquez | 23 | 358 | 140 | 128 | .522 | 352 | 4.04 | 2,088 | 6 | 0 | 2295.1 | 2,187 | 1,031 | 1,108 | 298 | 582 | 68 | 4 | 42 | 9,559 | 69 | 8.19 | 2.28 | 3.59 | 1.17 | 21.8 | 6.1 | 1.21 | .290 | 4.34 | 92 | 3.78 | 86 | 8.58 | 153.9 | |
| 18 | E. Santana | 21 | 425 | 151 | 129 | .539 | 386 | 4.11 | 1,978 | 11 | 0 | 2486.2 | 2,391 | 1,135 | 1,221 | 331 | 776 | 104 | 20 | 35 | 10,482 | 104 | 7.16 | 2.81 | 2.55 | 1.20 | 18.9 | 7.4 | 1.27 | .282 | 4.42 | 99 | 4.31 | 104 | 8.65 | -44.1 | |
| 19 | R. Oswalt | 20 | 365 | 163 | 102 | .615 | 341 | 3.36 | 1,852 | 8 | 0 | 2245.1 | 2,199 | 838 | 897 | 197 | 520 | 80 | 7 | 34 | 9,301 | 30 | 7.42 | 2.08 | 3.56 | 0.79 | 19.9 | 5.6 | 1.21 | .301 | 3.60 | 79 | 3.36 | 78 | 8.81 | 236.2 | |
| 20 | C. Kluber | 18 | 271 | 116 | 77 | .601 | 260 | 3.44 | 1,725 | 8 | 1 | 1641.2 | 1,486 | 627 | 684 | 177 | 368 | 65 | 4 | 9 | 6,688 | 31 | 9.46 | 2.02 | 4.69 | 0.97 | 25.8 | 5.5 | 1.13 | .301 | 3.75 | 83 | 3.22 | 78 | 8.15 | 161.7 | |
| 21 | J. Cueto | 18 | 370 | 144 | 113 | .560 | 365 | 3.52 | 1,857 | 8 | 0 | 2256.1 | 2,094 | 883 | 955 | 253 | 637 | 120 | 1 | 22 | 9,373 | 36 | 7.41 | 2.54 | 2.92 | 1.01 | 19.8 | 6.8 | 1.21 | .283 | 3.81 | 86 | 3.93 | 96 | 8.35 | 31.8 | |
| 22 | J. Lackey | 18 | 448 | 188 | 147 | .561 | 446 | 3.92 | 2,294 | 8 | 0 | 2840.1 | 2,862 | 1,237 | 1,347 | 319 | 815 | 133 | 0 | 32 | 12,030 | 125 | 7.27 | 2.58 | 2.81 | 1.01 | 19.1 | 6.8 | 1.29 | .300 | 4.27 | 92 | 3.94 | 94 | 9.07 | 79.6 | |
| 23 | M. Morris | 18 | 226 | 99 | 75 | .569 | 226 | 4.23 | 952 | 7 | 0 | 1422.1 | 1,505 | 669 | 742 | 152 | 381 | 62 | 0 | 27 | 6,075 | 22 | 6.02 | 2.41 | 2.50 | 0.96 | 15.7 | 6.3 | 1.33 | .299 | 4.70 | 99 | 4.05 | 94 | 9.52 | 38.6 | |
| 24 | C. Schilling | 18 | 214 | 106 | 51 | .675 | 192 | 3.50 | 1,377 | 5 | 9 | 1359.0 | 1,311 | 529 | 540 | 167 | 212 | 20 | 21 | 5 | 5,506 | 19 | 9.12 | 1.40 | 6.50 | 1.11 | 25.0 | 3.9 | 1.12 | .307 | 3.58 | 77 | 3.14 | 72 | 8.68 | 185.6 | |
| 25 | B. Sheets | 18 | 250 | 94 | 96 | .495 | 250 | 3.78 | 1,325 | 4 | 0 | 1596.2 | 1,577 | 670 | 736 | 184 | 369 | 32 | 0 | 28 | 6,640 | 53 | 7.47 | 2.08 | 3.59 | 1.04 | 20.0 | 5.6 | 1.22 | .295 | 4.15 | 89 | 3.65 | 85 | 8.89 | 120.8 | |