The Chicago Colts put up their most runs in a game versus the Louisville Colonels on June 29, 1897, with 36 runs.
Interpreted as:
most cubs runs in a regular-season game| TEAM | R | DATE | TM | OPP | RESULT | AB | H | 2B | 3B | HR | RBI | BB | HBP | SO | SB | CS | PA | TB | XBH | SH | SF | IBB | GIDP | AVG | OBP | SLG | OPS | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | Colts | 36 | 6/29/1897 |  CHI | vs | LOU | W 36-7 | ||||||||||||||||||||||
| 2 | | White Stockings | 35 | 7/24/1882 | CWS | vs | CLE | W 35-4 | ||||||||||||||||||||||
| 3 | | White Stockings | 31 | 7/3/1883 | CWS | vs | BUF | W 31-7 | ||||||||||||||||||||||
| 4 | | White Stockings | 30 | 7/22/1876 | CWS | vs | LOU | W 30-7 | ||||||||||||||||||||||
| 5 | | Colts | 28 | 8/25/1891 | CHI | vs |  BKN | W 28-5 | ||||||||||||||||||||||
| 6 | | Cubs | 26 | 8/18/1995 | CHC | @ |  COL | W 26-7 | 54 | 27 | 7 | 1 | 3 | 26 | 6 | 0 | 8 | 0 | 0 | 60 | 45 | 11 | 0 | 0 | 0 | 1 | .500 | .550 | .833 | 1.383 |
| 7 |  | Cubs | 26 | 8/25/1922 |  CHC | vs |  PHN | W 26-23 | 46 | 25 | 8 | 0 | 3 | 24 | 10 | 1 | 4 | 1 | 0 | 59 | 42 | 11 | 2 | .543 | .632 | .913 | 1.545 | |||
| 8 | | Colts | 26 | 8/1/1894 | CHI | vs |  STL | W 26-8 | ||||||||||||||||||||||
| 9 | | White Stockings | 26 | 9/6/1883 | CWS | vs | DET | W 26-6 | ||||||||||||||||||||||
| 10 |  | Cubs | 24 | 7/3/1945 |  CHC | @ |  BSN | W 24-2 | 53 | 28 | 7 | 0 | 1 | 22 | 8 | 1 | 0 | 0 | 0 | 62 | 38 | 8 | 0 | 0 | .528 | .597 | .717 | 1.314 | ||
| 11 | | Colts | 24 | 5/20/1895 | CHI | vs | PHI | W 24-6 | ||||||||||||||||||||||
| 12 | | Colts | 24 | 7/25/1894 | CHI | vs |  PIT | W 24-6 | ||||||||||||||||||||||
| 13 | | White Stockings | 24 | 7/1/1885 | CWS | vs |  BSN | W 24-10 | ||||||||||||||||||||||
| 14 | | White Stockings | 24 | 9/9/1882 | CWS | vs | TRO | W 24-1 | ||||||||||||||||||||||
| 15 |  | Cubs | 23 | 5/17/1977 |  CHC | vs |  SDP | W 23-6 | 50 | 24 | 4 | 0 | 7 | 22 | 5 | 1 | 0 | 0 | 0 | 57 | 49 | 11 | 1 | 0 | 0 | 1 | .480 | .536 | .980 | 1.516 |
| 16 |  | Cubs | 23 | 4/17/1954 |  CHC | vs | STL | W 23-13 | 44 | 20 | 7 | 0 | 2 | 21 | 12 | 0 | 1 | 0 | 0 | 57 | 33 | 9 | 0 | 1 | 1 | 2 | .455 | .561 | .750 | 1.311 |
| 17 | | White Stockings | 23 | 7/14/1882 | CWS | vs | DET | W 23-4 | ||||||||||||||||||||||
| 18 | | White Stockings | 23 | 8/26/1876 | CWS | vs | STL | W 23-3 | ||||||||||||||||||||||
| 19 | | White Stockings | 23 | 7/25/1876 | CWS | vs | CIN | W 23-3 | ||||||||||||||||||||||
| 20 | | Cubs | 22 | 6/3/1987 | CHC | vs |  HOU | W 22-7 | 44 | 21 | 3 | 0 | 6 | 21 | 9 | 0 | 6 | 1 | 0 | 54 | 42 | 9 | 0 | 1 | 0 | 1 | .477 | .556 | .955 | 1.510 |
| 21 | | Cubs | 22 | 5/17/1979 | CHC | vs |  PHI | L 22-23 | 56 | 26 | 3 | 1 | 6 | 22 | 3 | 0 | 4 | 0 | 0 | 59 | 49 | 10 | 0 | 0 | 0 | 2 | .464 | .492 | .875 | 1.367 |
| 22 |  | Cubs | 22 | 8/13/1937 |  CHC | vs |  CIN | W 22-6 | 46 | 21 | 0 | 2 | 0 | 17 | 9 | 0 | 4 | 0 | 0 | 55 | 25 | 2 | 0 | 0 | .457 | .545 | .543 | 1.089 | ||
| 23 | | White Stockings | 22 | 7/4/1884 | CWS | vs | PHN | W 22-3 | ||||||||||||||||||||||
| 24 | | White Stockings | 22 | 5/30/1883 | CWS | @ | PHN | W 22-4 | ||||||||||||||||||||||
| 25 | | Cubs | 21 | 4/23/2022 | CHC | vs | PIT | W 21-0 | 48 | 23 | 4 | 0 | 1 | 19 | 4 | 1 | 3 | 2 | 0 | 53 | 30 | 5 | 0 | 0 | 0 | 1 | .479 | .528 | .625 | 1.153 |
Results may be incomplete. StatMuse has complete team, game-level data for runs going back to the 1901 season.
Some of the information used here was obtained free of charge from Retrosheet.
Brewers 
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DET 
Yankees 
Rays 
Twins 
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