Brent Rooker had the most at-bats by a designated hitter in 2025, with 626 at-bats.

	NAME	AB	SEASON	TM	G	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS	WRC	WRAA	WOBA	WRC+	BRAA
1	Brent Rooker B. Rooker	626	2025	ATH	162	92	164	40	3	30	89	65	5	155	6	1	698	300	73	0	2	4	13	.262	.335	.479	.814	103	20.2	.349	125	20.4
2	Shohei Ohtani S. Ohtani	611	2025	LAD	158	146	172	25	9	55	102	109	3	187	20	6	725	380	89	0	2	20	9	.282	.392	.622	1.014	147	61.7	.418	173	63.1
3	Rafael Devers R. Devers	607	2025	TOT	163	99	153	33	0	35	109	112	6	192	1	1	729	291	68	0	4	10	16	.252	.372	.479	.851	117	30.9	.365	135	29.9
4	Kyle Schwarber K. Schwarber	604	2025	PHI	162	111	145	23	2	56	132	108	11	197	10	2	724	340	81	0	1	6	4	.240	.365	.563	.928	132	46	.391	153	45.8
5	Yandy Díaz Y. Díaz	583	2025	TBR	150	79	175	29	1	25	83	57	6	92	3	1	651	281	55	0	5	4	12	.300	.366	.482	.848	104	27.1	.364	140	30.4
6	Christian Yelich C. Yelich	573	2025	MIL	150	88	151	21	0	29	103	64	6	167	16	6	644	259	50	0	1	6	6	.264	.343	.452	.795	92	15.7	.343	120	15.5
7	Seiya Suzuki S. Suzuki	571	2025	CHC	151	75	140	31	3	32	103	71	1	164	5	2	651	273	66	0	8	1	13	.245	.326	.478	.804	93	16	.343	123	18.1
8	Trevor Larnach T. Larnach	503	2025	MIN	142	62	126	24	1	17	60	53	4	122	4	4	566	203	42	0	6	2	19	.250	.323	.404	.727	69	1.6	.317	103	1.8
9	George Springer G. Springer	498	2025	TOR	140	106	154	27	1	32	84	69	8	111	18	1	579	279	60	0	4	3	14	.309	.399	.560	.959	113	44.6	.408	167	45.4
10	Marcell Ozuna M. Ozuna	487	2025	ATL	145	61	113	19	0	21	68	94	3	144	0	0	591	195	40	0	7	2	11	.232	.355	.400	.756	80	10.1	.334	113	9.2
11	Andrew McCutchen A. McCutchen	477	2025	PIT	135	51	114	22	0	13	57	67	2	118	1	1	549	175	35	0	3	5	12	.239	.333	.367	.700	63	-1.8	.309	95	-3.3
12	Jorge Polanco J. Polanco	471	2025	SEA	138	64	125	30	0	26	78	42	3	82	6	3	524	233	56	3	5	1	7	.265	.326	.495	.821	78	15.7	.350	132	19.5
13	Kyle Manzardo K. Manzardo	470	2025	CLE	142	47	110	19	2	27	70	48	8	135	2	0	531	214	48	0	5	2	7	.234	.313	.455	.768	70	7.1	.329	113	7.8
14	Josh Bell J. Bell	468	2025	WSH	140	54	111	16	1	22	63	57	5	88	0	3	533	195	39	0	3	1	15	.237	.325	.417	.741	68	4.7	.324	108	5.1
15	Mike Trout M. Trout	456	2025	LAA	130	73	106	14	1	26	64	87	6	178	2	0	555	200	41	0	6	10	7	.232	.359	.439	.797	79	13.6	.343	119	12.4
16	Gavin Lux G. Lux	446	2025	CIN	140	49	120	28	2	5	53	56	0	114	1	0	503	167	35	0	1	0	3	.269	.350	.374	.724	63	3.8	.322	100	0
17	Wilmer Flores W. Flores	419	2025	SFG	125	44	101	10	0	16	71	34	7	88	1	0	463	159	26	0	3	0	14	.241	.307	.379	.686	51	-4.1	.302	95	-2.6
18	Colt Keith C. Keith	414	2025	DET	137	65	106	22	2	13	45	48	2	102	1	1	468	171	37	0	4	1	7	.256	.333	.413	.746	60	4.7	.326	110	5.4
19	Iván Herrera I. Herrera	388	2025	STL	107	54	110	13	0	19	66	43	15	84	8	2	450	180	32	0	4	1	20	.284	.373	.464	.837	72	18.8	.365	137	19.7
20	Starling Marte S. Marte	293	2025	NYM	98	37	79	14	0	9	34	22	9	68	7	2	329	120	23	1	4	0	7	.270	.335	.410	.745	42	3.5	.326	113	4.9
21	Randal Grichuk R. Grichuk	272	2025	TOT	113	35	62	18	1	9	27	17	1	61	0	1	293	109	28	0	3	1	6	.228	.273	.401	.674	29	-5.8	.289	81	-6.7
22	Joc Pederson J. Pederson	265	2025	TEX	96	28	48	10	1	9	26	34	5	65	2	0	305	87	20	0	1	0	5	.181	.285	.328	.614	27	-9.1	.276	75	-9
23	Giancarlo Stanton G. Stanton	249	2025	NYY	77	36	68	8	0	24	66	29	1	96	0	0	280	148	32	0	1	3	5	.273	.350	.594	.944	52	18.6	.395	157	18.7
24	Pavin Smith P. Smith	244	2025	AZ	87	36	63	17	1	8	28	41	0	92	2	2	287	106	26	0	2	1	7	.258	.362	.434	.797	42	8.1	.348	123	7.7
25	Anthony Santander A. Santander	194	2025	TOR	54	16	34	5	0	6	18	25	1	61	0	0	221	57	11	0	1	1	6	.175	.271	.294	.565	16	-10.4	.255	61	-10.1