Walter Johnson has won the most career games, with 417 wins.

Interpreted as:

most game regular-season winner by player

	NAME	W	L	W%	G	GS	ERA	SO	CG	SHO	SV	IP	H	ER	R	HR	BB	HBP	GF	IBB	TBF	WP	K/9	BB/9	K/BB	HR/9	K%	BB%	WHIP	BABIP	RA	H/9
1	Walter Johnson W. Johnson	417	0	1.000	417	376	0.97	2,182	339	109	0	3521.1	2,439		615	43	705	99	41		13,494	76	5.58	1.80	3.10	0.11	16.2	5.2	0.89	.229	1.57	6.23
2	Grover Alexander G. Alexander	373	0	1.000	373	350	1.34	1,448	336	88	0	3282.1	2,586		683	68	518	32	22		12,702	16	3.97	1.42	2.80	0.19	11.4	4.1	0.95	.237	1.87	7.09
3	Christy Mathewson C. Mathewson	373	0	1.000	373	343	0.58	1,676	304	79	0	3096.1	2,382		639	50	492	29	30			58	4.87	1.43	3.41	0.15		4.1	0.93	.241	1.86	6.92
4	Warren Spahn W. Spahn	363	0	1.000	363	358	1.73	1,579	322	63	0	3186.2	2,432	614	688	173	756	17	4	21	12,464	37	4.46	2.14	2.09	0.49	12.7	6.1	1.00	.227	1.94	6.87
5	Greg Maddux G. Maddux	355	0	1.000	355	355	1.83	1,767	92	35	0	2602.1	2,020	529	593	125	416	57	0	43	10,038	29	6.11	1.44	4.25	0.43	17.6	4.1	0.94	.247	2.05	6.99
6	Roger Clemens R. Clemens	354	0	1.000	354	354	1.73	2,599	92	46	0	2682.0	1,891	515	553	125	680	70	0	12	10,452	64	8.72	2.28	3.82	0.42	24.9	6.5	0.96	.253	1.86	6.35
7	Steve Carlton S. Carlton	329	0	1.000	329	327	1.73	2,261	216	55	0	2783.1	1,997	536	602	123	789	25	1	30	10,859	92	7.31	2.55	2.87	0.40	20.8	7.3	1.00	.245	1.95	6.46
8	Eddie Plank E. Plank	326	0	1.000	326	299	0.76	1,502	291	69	0	2812.2	2,086		566	18	626	108	26			31	4.81	2.00	2.40	0.06		5.9	0.96	.246	1.81	6.67
9	Nolan Ryan N. Ryan	324	0	1.000	324	318	1.45	2,802	163	61	0	2584.1	1,413	415	479	74	1,133	62	4	12	10,119	87	9.76	3.95	2.47	0.26	27.7	11.2	0.99	.221	1.67	4.92
10	Don Sutton D. Sutton	324	0	1.000	324	321	1.66	1,751	151	58	0	2572.2	1,837	474	529	148	513	21	2	16	9,922	46	6.13	1.79	3.41	0.52	17.6	5.2	0.91	.226	1.85	6.43
11	Phil Niekro P. Niekro	318	0	1.000	318	302	1.77	1,566	180	45	0	2531.1	1,876	497	573	147	709	56	14	11	9,989	77	5.57	2.52	2.21	0.52	15.7	7.1	1.02	.230	2.04	6.67
12	Gaylord Perry G. Perry	314	0	1.000	314	305	1.54	1,762	226	53	0	2648.0	1,905	453	532	107	550	40	5	28	10,212	52	5.99	1.87	3.20	0.36	17.3	5.4	0.93	.232	1.81	6.47
13	Tom Seaver T. Seaver	311	0	1.000	311	310	1.61	2,014	186	61	0	2575.0	1,740	460	494	131	628	27	1	25	9,900	45	7.04	2.19	3.21	0.46	20.3	6.3	0.92	.227	1.73	6.08
14	Tom Glavine T. Glavine	305	0	1.000	305	305	1.95	1,318	50	25	0	2207.0	1,731	479	539	117	563	27	0	32	8,697	29	5.37	2.30	2.34	0.48	15.2	6.5	1.04	.242	2.20	7.06
15	Randy Johnson R. Johnson	303	0	1.000	303	301	1.86	2,721	75	37	0	2257.1	1,509	466	518	146	615	84	1	6	8,788	46	10.85	2.45	4.42	0.58	31.0	7.0	0.94	.261	2.07	6.02
16	Early Wynn E. Wynn	300	0	1.000	300	287	1.68	1,362	224	49	0	2540.1	1,837	475	536	112	834	27	13	4	10,081	24	4.83	2.95	1.63	0.40	13.5	8.3	1.05	.223	1.90	6.51
17	Lefty Grove L. Grove	300	0	1.000	300	268	2.11	1,483	242	35	0	2482.1	2,133	582	673	72	628	18	28		10,052	25	5.38	2.28	2.36	0.26	14.8	6.2	1.11	.263	2.44	7.73
18	Tommy John T. John	288	0	1.000	288	284	1.57	1,051	129	46	0	2282.2	1,840	399	475	85	442	42	3	26	8,883	51	4.14	1.74	2.38	0.34	11.8	5.0	1.00	.242	1.87	7.25
19	Bert Blyleven B. Blyleven	287	0	1.000	287	286	1.60	1,803	167	60	0	2336.2	1,691	416	471	105	523	58	0	17	9,033	37	6.94	2.01	3.45	0.40	20.0	5.8	0.95	.242	1.81	6.51
20	Robin Roberts R. Roberts	286	0	1.000	286	275	2.04	1,285	238	45	0	2466.1	1,953	560	608	183	389	26	9	8	9,575	15	4.69	1.42	3.30	0.67	13.4	4.1	0.95	.230	2.22	7.13
21	Fergie Jenkins F. Jenkins	284	0	1.000	284	278	1.85	1,754	208	49	0	2394.0	1,782	493	557	177	409	38	4	29	9,241	30	6.59	1.54	4.29	0.67	19.0	4.4	0.92	.234	2.09	6.70
22	Jim Kaat J. Kaat	283	0	1.000	283	260	1.87	1,273	146	31	0	2198.0	1,804	456	536	133	383	47	15	24	8,637	52	5.21	1.57	3.32	0.54	14.7	4.4	0.99	.246	2.19	7.39
23	Red Ruffing R. Ruffing	273	0	1.000	273	264	2.18	1,093	228	45	0	2351.1	1,903	569	635	82	700	17	9		9,439	22	4.18	2.68	1.56	0.31	11.6	7.4	1.11	.241	2.43	7.28
24	Mike Mussina M. Mussina	270	0	1.000	270	270	2.16	1,560	43	23	0	1949.1	1,565	468	499	134	356	24	0	6	7,582	33	7.20	1.64	4.38	0.62	20.6	4.7	0.99	.260	2.30	7.23
25	Burleigh Grimes B. Grimes	270	0	1.000	270	249	2.07	919	234	35	0	2309.2	2,065	531	663	60	591	45	17		9,403	39	3.58	2.30	1.55	0.23	9.8	6.3	1.15	.257	2.58	8.05