Grover Alexander has won the most career games by a pitcher against a team, with 70 wins against the Reds.

Interpreted as:

most game regular-season winners by a player vs one franchise

	NAME	W	OPP	L	W%	G	GS	ERA	SO	CG	SHO	SV	IP	H	ER	R	HR	BB	HBP	GF	IBB	TBF	WP	K/9	BB/9	K/BB	HR/9	K%	BB%	WHIP	BABIP	RA	H/9
1	Grover Alexander G. Alexander	70	Reds	0	1.000	70	67	1.16	251	65	20	0	619.2	473		102	4	98	12	3		2,356	3	3.65	1.42	2.56	0.06	10.7	4.2	0.92	.236	1.48	6.87
2	Walter Johnson W. Johnson	66	Tigers	0	1.000	66	59	1.08	316	51	12	0	540.2	393		118	5	124	13	7		2,077	14	5.26	2.06	2.55	0.08	15.2	6.0	0.96	.240	1.96	6.54
3	Christy Mathewson C. Mathewson	65	Reds	0	1.000	65	60	0.62	274	57	12	0	554.2	437		122	8	89	7	5		2,148	6	4.45	1.44	3.08	0.13	12.8	4.1	0.95	.242	1.98	7.09
4	Warren Spahn W. Spahn	64	Cardinals	0	1.000	64	63	1.66	244	58	11	0	562.1	431	104	121	22	137	2	1	5	2,219	13	3.91	2.19	1.78	0.35	11.0	6.2	1.01	.225	1.94	6.90
5	Walter Johnson W. Johnson	63	White Sox	0	1.000	63	55	0.94	335	51	14	0	525.0	334		90	3	92	11	8		1,978	12	5.74	1.58	3.64	0.05	16.9	4.7	0.81	.215	1.54	5.73
6	Warren Spahn W. Spahn	62	Reds	0	1.000	62	60	1.78	252	54	9	0	536.1	428	106	118	31	129	5	1	7	2,117	6	4.23	2.16	1.95	0.52	11.9	6.1	1.04	.234	1.98	7.18
7	Walter Johnson W. Johnson	61	Yankees	0	1.000	61	57	0.96	346	52	20	0	541.0	346		89	7	113	14	4		2,053	11	5.76	1.88	3.06	0.12	16.9	5.5	0.85	.216	1.48	5.76
8	Lefty Grove L. Grove	60	Tigers	0	1.000	60	53	2.19	281	50	7	0	496.2	410	121	137	19	135	3	5		2,005	5	5.09	2.45	2.08	0.34	14.0	6.7	1.10	.250	2.48	7.43
9	Eddie Plank E. Plank	60	Tigers	0	1.000	60	55	0.91	266	55	11	0	521.2	429		117	2	127	16	5			4	4.59	2.19	2.09	0.03		6.3	1.07	.265	2.02	7.40
10	Walter Johnson W. Johnson	59	Athletics	0	1.000	59	56	1.03	326	49	23	0	514.2	352		83	13	98	14	3		1,986	10	5.70	1.71	3.33	0.23	16.4	4.9	0.87	.221	1.45	6.16
11	Walter Johnson W. Johnson	59	Indians	0	1.000	59	51	0.91	290	46	12	0	486.2	357		85	5	94	13	8		1,874	14	5.36	1.74	3.09	0.09	15.5	5.0	0.93	.239	1.57	6.60
12	Grover Alexander G. Alexander	57	Braves	0	1.000	57	53	1.35	212	51	10	0	492.0	395		113	12	71	4	4		1,927	3	3.88	1.30	2.99	0.22	11.0	3.7	0.95	.235	2.07	7.23
13	Warren Spahn W. Spahn	56	Giants	0	1.000	56	56	1.88	249	53	6	0	498.2	380	104	109	44	110	3	0	1	1,944	5	4.49	1.99	2.26	0.79	12.8	5.7	0.98	.218	1.97	6.86
14	Grover Alexander G. Alexander	56	Robins	0	1.000	56	51	1.15	204	50	16	0	486.1	376		92	4	68	2	5		1,882	6	3.78	1.26	3.00	0.07	10.8	3.6	0.91	.232	1.70	6.96
15	Walter Johnson W. Johnson	56	Browns	0	1.000	56	50	0.92	291	46	13	0	467.1	331		79	6	87	15	6		1,797	11	5.60	1.68	3.34	0.12	16.2	4.8	0.89	.232	1.52	6.37
16	Christy Mathewson C. Mathewson	55	Braves	0	1.000	55	52	0.55	287	44	14	0	460.0	343		85	6	88	4	3		1,778	7	5.62	1.72	3.26	0.12	16.1	4.9	0.94	.242	1.66	6.71
17	Christy Mathewson C. Mathewson	54	Pirates	0	1.000	54	47	0.49	223	43	8	0	441.1	361		101	10	58	4	7			13	4.55	1.18	3.84	0.20		3.4	0.95	.248	2.06	7.36
18	Walter Johnson W. Johnson	53	Red Sox	0	1.000	53	48	0.89	278	44	15	0	446.0	326		71	4	97	19	5		1,729	4	5.61	1.96	2.87	0.08	16.1	5.6	0.95	.242	1.43	6.58
19	Christy Mathewson C. Mathewson	52	Cardinals	0	1.000	52	48	0.77	221	38	9	0	419.2	343		100	9	80	2	4		1,632	6	4.74	1.72	2.76	0.19	13.5	4.9	1.01	.253	2.14	7.36
20	Christy Mathewson C. Mathewson	52	Phillies	0	1.000	52	49	0.57	228	43	9	0	425.1	336		97	7	82	7	3		1,655	10	4.82	1.74	2.78	0.15	13.8	5.0	0.98	.247	2.05	7.11
21	Ted Lyons T. Lyons	51	Indians	0	1.000	51	45	1.74	85	43	3	0	430.0	373	83	107	13	92	4	4		1,715	2	1.78	1.93	0.92	0.27	5.0	5.4	1.08	.237	2.24	7.81
22	Red Faber R. Faber	51	Tigers	0	1.000	51	48	1.78	160	45	8	0	441.0	366	87	106	8	122	7	3		1,786	5	3.27	2.49	1.31	0.16	9.0	6.8	1.11	.240	2.16	7.47
23	Warren Spahn W. Spahn	49	Pirates	0	1.000	49	48	1.72	237	41	9	0	424.2	334	81	94	16	120	0	1	4	1,683	3	5.02	2.54	1.98	0.34	14.1	7.1	1.07	.243	1.99	7.08
24	Early Wynn E. Wynn	49	Athletics	0	1.000	49	48	1.79	183	38	5	0	418.0	315	83	90	15	121	2	1	0	1,650	1	3.94	2.61	1.51	0.32	11.1	7.3	1.04	.226	1.94	6.78
25	Carl Hubbell C. Hubbell	49	Pirates	0	1.000	49	47	1.79	162	44	5	0	426.1	363	85	104	15	84	6	2		1,707	8	3.42	1.77	1.93	0.32	9.5	4.9	1.05	.242	2.20	7.66