Dennis Santana pitched in the most games for the Pirates in 2025, with 70 games.

	NAME	G	SEASON	TM	W	L	W%	GS	ERA	SO	CG	SHO	SV	IP	H	ER	R	HR	BB	HBP	GF	IBB	TBF	WP	K/9	BB/9	K/BB	HR/9	K%	BB%	WHIP	BABIP	RA	ERA-	FIP	FIP-	H/9	PRAA
1	Dennis Santana D. Santana	70	2025	PIT	4	5	.444	0	2.18	60	0	0	16	70.1	44	17	18	5	17	3	34	0	270	0	7.68	2.18	3.53	0.64	22.2	6.3	0.87	.211	2.30	51	3.20	77	5.63	7.3
2	Caleb Ferguson C. Ferguson	45	2025	PIT	2	2	.500	0	3.74	34	0	0	0	43.1	33	18	18	1	14	5	2	2	176	0	7.06	2.91	2.43	0.21	19.3	8.0	1.08	.262	3.74	87	3.17	77	6.85	4.6
3	Isaac Mattson I. Mattson	44	2025	PIT	3	3	.500	0	2.45	45	0	0	0	47.2	35	13	14	4	19	2	12	2	198	0	8.50	3.59	2.37	0.76	22.7	9.6	1.13	.242	2.64	57	3.65	88	6.61	2.5
4	David Bednar D. Bednar	42	2025	PIT	2	5	.286	0	2.37	51	0	0	17	38.0	32	10	12	2	10	1	34	2	154	3	12.08	2.37	5.10	0.47	33.1	6.5	1.11	.333	2.84	55	2.00	48	7.58	9
5	Ryan Borucki R. Borucki	35	2025	PIT	1	3	.250	0	5.28	27	0	0	0	30.2	26	18	20	4	12	1	8	1	126	2	7.92	3.52	2.25	1.17	21.4	9.5	1.24	.268	5.87	123	4.33	105	7.63	-0.7
6	Chase Shugart C. Shugart	35	2025	PIT	4	3	.571	0	3.40	31	0	0	0	45.0	33	17	18	6	17	1	11	2	181	3	6.20	3.40	1.82	1.20	17.1	9.4	1.11	.214	3.60	79	4.68	113	6.60	-2.8
7	Carmen Mlodzinski C. Mlodzinski	34	2025	PIT	5	8	.385	12	3.55	89	0	0	0	99.0	102	39	42	8	27	4	7	0	419	5	8.09	2.45	3.30	0.73	21.2	6.4	1.30	.323	3.82	82	3.32	80	9.27	8.9
8	Mitch Keller M. Keller	32	2025	PIT	6	15	.286	32	4.19	150	0	0	0	176.1	171	82	91	21	51	10	0	0	749	5	7.66	2.60	2.94	1.07	20.0	6.8	1.26	.290	4.64	97	4.01	97	8.73	2.3
9	Paul Skenes P. Skenes	32	2025	PIT	10	10	.500	32	1.97	216	1	0	0	187.2	136	41	45	11	42	6	0	0	733	2	10.36	2.01	5.14	0.53	29.5	5.7	0.95	.273	2.16	46	2.36	57	6.52	37
10	Kyle Nicolas K. Nicolas	31	2025	PIT	1	2	.333	0	4.74	34	0	0	0	38.0	34	20	21	3	18	2	5	0	167	1	8.05	4.26	1.89	0.71	20.4	10.8	1.37	.282	4.97	110	3.94	95	8.05	0.8
11	Andrew Heaney A. Heaney	26	2025	PIT	5	10	.333	23	5.39	84	0	0	0	120.1	125	72	74	24	39	9	0	0	525	2	6.28	2.92	2.15	1.80	16.0	7.4	1.36	.274	5.53	125	5.52	134	9.35	-18.6
12	Braxton Ashcraft B. Ashcraft	26	2025	PIT	4	4	.500	8	2.71	71	0	0	0	69.2	63	21	22	3	24	2	6	1	292	1	9.17	3.10	2.96	0.39	24.3	8.2	1.25	.313	2.84	63	2.77	67	8.14	10.5
13	Colin Holderman C. Holderman	24	2025	PIT	0	2	.000	0	7.01	18	0	0	1	25.2	34	20	21	4	16	2	6	1	125	3	6.31	5.61	1.13	1.40	14.4	12.8	1.95	.353	7.36	163	5.86	142	11.92	-4.9
14	Yohan Ramírez Y. Ramírez	24	2025	PIT	3	3	.500	0	5.40	45	0	0	0	33.1	33	20	25	4	16	4	5	1	155	4	12.15	4.32	2.81	1.08	29.0	10.3	1.47	.337	6.75	126	3.79	92	8.91	1.3
15	Mike Burrows M. Burrows	23	2025	PIT	2	4	.333	19	3.94	97	0	0	0	96.0	88	42	43	13	31	5	0	1	402	2	9.09	2.91	3.13	1.22	24.1	7.7	1.24	.293	4.03	92	3.99	97	8.25	1.5
16	Bailey Falter B. Falter	22	2025	PIT	7	5	.583	22	3.73	70	0	0	0	113.1	95	47	53	17	39	1	0	0	457	4	5.56	3.10	1.79	1.35	15.3	8.5	1.18	.236	4.21	87	4.90	119	7.54	-9.7
17	Joey Wentz J. Wentz	19	2025	PIT	2	1	.667	0	4.15	22	0	0	0	26.0	25	12	14	2	11	1	7	2	115	0	7.62	3.81	2.00	0.69	19.1	9.6	1.38	.291	4.85	97	3.82	92	8.65	0.9
18	Dauri Moreta D. Moreta	18	2025	PIT	1	1	.500	0	3.24	19	0	0	0	16.2	16	6	8	2	7	0	6	1	68	0	10.26	3.78	2.71	1.08	27.9	10.3	1.38	.350	4.32	75	3.67	89	8.64	0.9
19	Justin Lawrence J. Lawrence	17	2025	PIT	1	0	1.000	0	0.51	23	0	0	0	17.2	9	1	1	0	8	2	3	2	69	2	11.72	4.08	2.88	0.00	33.3	11.6	0.96	.250	0.51	12	2.22	54	4.58	3.7
20	Evan Sisk E. Sisk	14	2025	PIT	1	1	.500	0	4.38	14	0	0	0	12.1	11	6	6	1	5	2	4	0	54	2	10.22	3.65	2.80	0.73	25.9	9.3	1.30	.313	4.38	102	3.61	87	8.03	0.7
21	Tanner Rainey T. Rainey	11	2025	PIT	0	1	.000	0	10.57	9	0	0	0	7.2	7	9	9	0	6	1	0	0	37	0	10.57	7.04	1.50	0.00	24.3	16.2	1.70	.333	10.57	246	3.52	85	8.22	0.5
22	Génesis Cabrera G. Cabrera	9	2025	PIT	0	0		0	4.91	7	0	0	0	11.0	12	6	6	2	1	1	1	0	46	0	5.73	0.82	7.00	1.64	15.2	2.2	1.18	.286	4.91	114	4.76	115	9.82	-0.8
23	Johan Oviedo J. Oviedo	9	2025	PIT	2	1	.667	9	3.57	42	0	0	0	40.1	26	16	17	6	23	3	0	0	170	1	9.37	5.13	1.83	1.34	24.7	13.5	1.21	.208	3.79	83	4.91	119	5.80	-3.5
24	Tim Mayza T. Mayza	7	2025	PIT	0	0		0	2.89	8	0	0	0	9.1	9	3	3	1	1	1	4	0	40	0	7.71	0.96	8.00	0.96	20.0	2.5	1.07	.276	2.89	67	3.45	83	8.68	0.7
25	Bubba Chandler B. Chandler	7	2025	PIT	4	1	.800	4	4.02	31	0	0	1	31.1	25	14	14	2	4	3	1	0	124	1	8.90	1.15	7.75	0.57	25.0	3.2	0.93	.274	4.02	94	2.65	64	7.18	5.2