Between the 2000 and 2009 seasons, David Weathers threw in the most games, with 713 games.

Interpreted as:

most regular-season games as a pitcher in the 2000s

	NAME	G	W	L	W%	GS	ERA	SO	CG	SHO	SV	IP	H	ER	R	HR	BB	HBP	GF	IBB	TBF	WP	K/9	BB/9	K/BB	HR/9	K%	BB%	WHIP	BABIP	RA	ERA-	FIP	FIP-	H/9	PRAA
1	David Weathers D. Weathers	713	42	52	.447	2	3.37	555	0	0	73	770.0	707	288	316	76	325	33	261	51	3,294	11	6.49	3.80	1.71	0.89	16.8	9.9	1.34	.274	3.69	78	4.31	97	8.26	9.9
2	LaTroy Hawkins L. Hawkins	654	34	37	.479	0	3.24	494	0	0	87	676.0	644	243	261	56	208	7	258	24	2,815	35	6.58	2.77	2.38	0.75	17.5	7.4	1.26	.287	3.47	71	3.64	82	8.57	59.8
3	Mariano Rivera M. Rivera	651	45	39	.536	0	2.08	669	0	0	397	713.1	548	165	182	38	137	30	590	18	2,811	7	8.44	1.73	4.88	0.48	23.8	4.9	0.96	.263	2.30	46	2.60	58	6.91	148.3
4	Alan Embree A. Embree	642	25	35	.417	0	4.73	482	0	0	23	542.0	538	285	306	66	179	13	163	28	2,314	10	8.00	2.97	2.69	1.10	20.8	7.7	1.32	.300	5.08	107	3.95	91	8.93	23.8
5	Kyle Farnsworth K. Farnsworth	626	26	44	.371	5	4.36	710	0	0	27	642.1	607	311	342	87	290	16	185	30	2,794	28	9.95	4.06	2.45	1.22	25.4	10.4	1.40	.308	4.79	100	4.06	92	8.50	25.9
6	Bob Howry B. Howry	618	39	43	.476	0	3.71	508	0	0	29	630.2	589	260	276	70	183	24	216	35	2,638	16	7.25	2.61	2.78	1.00	19.3	6.9	1.22	.280	3.94	82	3.90	87	8.41	40.6
7	Mike Timlin M. Timlin	595	43	37	.538	1	3.72	422	0	0	42	643.0	642	266	286	73	166	29	195	34	2,708	14	5.91	2.32	2.54	1.02	15.6	6.1	1.26	.282	4.00	83	4.14	95	8.99	14.8
8	Braden Looper B. Looper	594	69	61	.531	97	4.17	615	1	1	103	1089.2	1,141	505	547	124	341	39	290	33	4,681	18	5.08	2.82	1.80	1.02	13.1	7.3	1.36	.286	4.52	99	4.49	105	9.42	-25.2
9	Francisco Cordero F. Cordero	590	31	35	.470	0	3.17	645	0	0	250	624.0	554	220	248	42	281	20	426	23	2,678	25	9.30	4.05	2.30	0.61	24.1	10.5	1.34	.303	3.58	68	3.34	73	7.99	83.7
10	Todd Jones T. Jones	590	30	39	.435	1	4.30	449	0	0	191	605.1	660	289	316	56	212	21	348	26	2,640	19	6.68	3.15	2.12	0.83	17.0	8.0	1.44	.318	4.70	94	3.94	88	9.81	35.3
11	Steve Kline S. Kline	590	20	25	.444	0	3.32	311	0	0	38	488.1	458	180	199	38	198	18	188	31	2,076	15	5.73	3.65	1.57	0.70	15.0	9.5	1.34	.278	3.67	76	4.13	94	8.44	14.6
12	Ray King R. King	583	20	23	.465	0	3.39	273	0	0	2	400.1	365	151	170	32	171	16	97	17	1,697	15	6.14	3.84	1.60	0.72	16.1	10.1	1.34	.276	3.82	78	4.13	94	8.21	10.8
13	Justin Speier J. Speier	575	35	30	.538	0	3.88	549	0	0	17	625.2	557	270	286	93	205	45	172	35	2,657	35	7.90	2.95	2.68	1.34	20.7	7.7	1.22	.263	4.11	83	4.45	98	8.01	7.6
14	Mike Stanton M. Stanton	567	33	34	.493	0	3.83	404	0	0	19	516.2	522	220	236	36	193	17	149	41	2,226	18	7.04	3.36	2.09	0.63	18.1	8.7	1.38	.308	4.11	87	3.63	82	9.09	46.5
15	J.C. Romero	563	32	28	.533	22	4.11	469	0	0	4	578.1	532	264	287	51	328	33	101	38	2,555	34	7.30	5.10	1.43	0.79	18.4	12.8	1.49	.287	4.47	90	4.47	102	8.28	-5.9
16	Guillermo Mota G. Mota	558	34	35	.493	0	3.97	530	0	0	8	646.1	564	285	296	68	246	18	162	38	2,709	25	7.38	3.43	2.15	0.95	19.6	9.1	1.25	.269	4.12	94	4.02	93	7.85	21.6
17	Mike Myers M. Myers	558	19	12	.613	0	3.95	231	0	0	5	323.2	296	142	151	27	155	26	114	21	1,409	5	6.42	4.31	1.49	0.75	16.4	11.0	1.39	.277	4.20	85	4.41	97	8.23	5.2
18	Billy Wagner B. Wagner	558	23	24	.489	0	2.40	698	0	0	284	580.2	405	155	176	55	170	23	465	18	2,309	33	10.82	2.63	4.11	0.85	30.2	7.4	0.99	.257	2.73	55	2.89	65	6.28	97
19	Scott Eyre S. Eyre	552	20	17	.541	4	3.67	411	0	0	4	456.2	440	186	201	42	222	11	89	24	1,994	31	8.10	4.38	1.85	0.83	20.6	11.1	1.45	.304	3.96	82	3.99	91	8.67	18.8
20	Matt Herges M. Herges	550	43	33	.566	4	3.90	455	0	0	34	666.2	711	289	322	61	249	31	189	44	2,919	16	6.14	3.36	1.83	0.82	15.6	8.5	1.44	.306	4.35	90	4.16	95	9.60	17.8
21	Trevor Hoffman T. Hoffman	546	23	40	.365	0	2.77	523	0	0	363	533.0	432	164	180	46	124	5	466	20	2,142	17	8.83	2.09	4.22	0.78	24.4	5.8	1.04	.267	3.04	69	2.97	70	7.29	77.7
22	B.J. Ryan	546	20	28	.417	0	3.38	596	0	0	117	516.1	411	194	209	42	251	17	246	26	2,191	20	10.39	4.38	2.37	0.73	27.2	11.5	1.28	.287	3.64	76	3.36	74	7.16	65.4
23	Octavio Dotel O. Dotel	543	38	36	.514	20	3.52	855	0	0	83	685.0	548	268	294	87	298	29	217	27	2,897	32	11.23	3.92	2.87	1.14	29.5	10.3	1.24	.283	3.86	77	3.65	81	7.20	63.1
24	Arthur Rhodes A. Rhodes	542	37	26	.587	0	3.22	502	0	0	23	477.1	386	171	179	35	171	6	107	26	1,956	22	9.47	3.22	2.94	0.66	25.7	8.7	1.17	.283	3.38	73	3.02	68	7.28	75
25	Luis Vizcaino L. Vizcaino	542	35	30	.538	0	4.32	490	0	0	8	543.1	492	261	271	78	234	16	155	37	2,331	25	8.12	3.88	2.09	1.29	21.0	10.0	1.34	.274	4.49	98	4.51	101	8.15	-3.4