Ted Lyons had the most games pitched when allowing 6+ runs, with 130 games.

Interpreted as:

most regular-season games giving up by a player 6 or more runs

	NAME	G	R	W	L	W%	GS	ERA	SO	CG	SHO	SV	IP	H	ER	HR	BB	HBP	GF	IBB	TBF	WP	K/9	BB/9	K/BB	HR/9	K%	BB%	WHIP	BABIP	RA	H/9
1	Ted Lyons T. Lyons	130	940	16	101	.137	125	7.74	250	59	0	0	890.1	1,382	766	93	332	14	1		4,371	22	2.53	3.36	0.75	0.94	5.7	7.6	1.93	.350	9.50	13.97
2	Red Ruffing R. Ruffing	127	898	12	90	.118	126	8.68	351	33	0	0	788.2	1,221	761	103	368	11	0		3,924	17	4.01	4.20	0.95	1.18	8.9	9.4	2.01	.362	10.25	13.93
3	Burleigh Grimes B. Grimes	125	895	23	86	.211	120	7.59	260	44	0	0	832.0	1,305	702	53	363	31	4		4,150	27	2.81	3.93	0.72	0.57	6.3	8.7	2.00	.364	9.68	14.12
4	Earl Whitehill E. Whitehill	124	867	22	83	.210	124	8.39	291	32	0	0	790.2	1,230	737	76	400	24	0		3,977	17	3.31	4.55	0.73	0.87	7.3	10.1	2.06	.362	9.87	14.00
5	George Uhle G. Uhle	102	695	10	71	.123	99	7.82	211	33	0	0	655.2	1,033	570	37	246	36	0		3,263	16	2.90	3.38	0.86	0.51	6.5	7.5	1.95	.364	9.54	14.18
6	Nolan Ryan N. Ryan	99	655	5	81	.058	99	9.76	544	12	0	0	528.1	700	573	96	378	28	0	18	2,669	47	9.27	6.44	1.44	1.64	20.4	14.2	2.04	.372	11.16	11.92
7	Bobo Newsom B. Newsom	99	716	13	73	.151	98	8.70	366	31	0	0	638.1	930	617	69	380	10	0		3,224	14	5.16	5.36	0.96	0.97	11.4	11.8	2.05	.359	10.10	13.11
8	Sad Sam Jones S. Sam Jones	97	680	13	68	.160	93	8.23	186	28	0	0	613.2	956	561	44	266	13	1		3,007	12	2.73	3.90	0.70	0.65	6.2	8.8	1.99	.365	9.97	14.02
9	Phil Niekro P. Niekro	96	632	6	74	.075	96	9.14	342	10	0	0	529.2	800	538	116	240	21	0	14	2,637	21	5.81	4.08	1.43	1.97	13.0	9.1	1.96	.357	10.74	13.59
10	Early Wynn E. Wynn	96	648	8	71	.101	95	8.89	274	18	0	0	571.0	876	564	98	301	12	0	6	2,864	13	4.32	4.74	0.91	1.54	9.6	10.5	2.06	.357	10.21	13.81
11	Tim Wakefield T. Wakefield	94	641	4	74	.051	93	10.76	296	2	0	0	464.1	746	555	122	245	35	1	14	2,408	30	5.74	4.75	1.21	2.36	12.3	10.2	2.13	.365	12.42	14.46
12	Jack Morris J. Morris	89	601	14	62	.184	89	10.23	288	2	0	0	475.0	743	540	114	250	17	0	25	2,412	40	5.46	4.74	1.15	2.16	11.9	10.4	2.09	.361	11.39	14.08
13	Livan Hernandez L. Hernandez	88	602	4	70	.054	87	11.82	268	0	0	0	426.1	762	560	112	197	14	0	15	2,216	13	5.66	4.16	1.36	2.36	12.1	8.9	2.25	.400	12.71	16.09
14	Gaylord Perry G. Perry	88	580	4	71	.053	88	9.44	308	10	0	0	485.1	776	509	97	193	13	0	27	2,394	27	5.71	3.58	1.60	1.80	12.9	8.1	2.00	.381	10.76	14.39
15	Wes Ferrell W. Ferrell	88	632	15	59	.203	86	8.87	188	31	0	0	552.0	901	544	71	278	7	2		2,804	10	3.07	4.53	0.68	1.16	6.7	9.9	2.14	.367	10.30	14.69
16	Grover Alexander G. Alexander	87	595	11	60	.155	85	6.38	225	34	0	0	620.2	927		48	177	13	1		2,915	8	3.26	2.57	1.27	0.70	7.7	6.1	1.78	.358	8.63	13.44
17	Walter Johnson W. Johnson	87	585	13	65	.167	84	4.81	327	51	0	0	625.1	862		29	225	32	2		2,968	25	4.71	3.24	1.45	0.42	11.0	7.6	1.74	.354	8.42	12.41
18	Mel Harder M. Harder	85	564	17	58	.227	84	8.23	171	12	0	0	517.1	821	473	53	208	11	1		2,562	11	2.97	3.62	0.82	0.92	6.7	8.1	1.99	.362	9.81	14.28
19	Howard Ehmke H. Ehmke	84	613	12	62	.162	81	8.20	212	32	0	0	561.2	861	512	37	295	43	3			9	3.40	4.73	0.72	0.59		10.6	2.06	.377	9.82	13.80
20	Bartolo Colon B. Colon	83	566	1	71	.014	83	12.50	259	0	0	0	369.1	699	513	132	151	13	0	12	1,961	4	6.31	3.68	1.72	3.22	13.2	7.7	2.30	.403	13.79	17.03
21	Eppa Rixey E. Rixey	82	564	11	64	.147	80	8.06	140	17	0	0	493.2	807	442	32	169	7	1		2,428	14	2.55	3.08	0.83	0.58	5.8	7.0	1.98	.373	10.28	14.71
22	Kenny Rogers K. Rogers	81	556	4	55	.068	80	11.57	223	3	0	0	394.1	666	507	102	191	25	0	8	2,048	15	5.09	4.36	1.17	2.33	10.9	9.3	2.17	.374	12.69	15.20
23	Robin Roberts R. Roberts	80	530	14	59	.192	80	8.38	222	20	0	0	500.2	739	466	118	142	6	0	15	2,387	4	3.99	2.55	1.56	2.12	9.3	5.9	1.76	.327	9.53	13.28
24	Jamie Moyer J. Moyer	79	549	2	60	.032	79	12.06	224	0	0	0	369.1	669	495	129	156	23	0	13	1,936	11	5.46	3.80	1.44	3.14	11.6	8.1	2.23	.385	13.38	16.30
25	Bobby Witt B. Witt	79	524	3	62	.046	79	11.97	254	1	0	0	356.1	597	474	84	270	7	0	11	1,913	26	6.42	6.82	0.94	2.12	13.3	14.1	2.43	.395	13.23	15.08