Cy Young has lost the most career games, with 316 games.

Interpreted as:

most games lost in the regular season by starting by a player wb

	NAME	L	GS	W	L%	G	W%	ERA	SO	CG	SHO	SV	IP	H	ER	R	HR	BB	HBP	GF	IBB	TBF	WP	K/9	BB/9	K/BB	HR/9	K%	BB%	WHIP	BABIP	RA	ERA-	FIP	FIP-	H/9	PRAA
1	Cy Young C. Young	316	815	511	.382	906	.618	2.63	2,803	749	76	17	7356.0	7,092	2,147	3,167	138	1,217	161	84		29,565	156	3.43	1.49	2.30	0.17	9.5	4.1	1.13	.275	3.87	74	2.84	79	8.68	620
2	Pud Galvin P. Galvin	308	681	361	.460	697	.540	2.87	1,799	639	57	1	5941.1	6,352	1,895	3,315	121	744	54	18		25,160	220	2.73	1.13	2.42	0.18	7.2	3.0	1.19	.278	5.02	94	2.97	95	9.62	94.5
3	Nolan Ryan N. Ryan	292	773	324	.474	807	.526	3.19	5,714	222	61	3	5386.0	3,923	1,911	2,178	321	2,795	158	13	78	22,575	277	9.55	4.67	2.04	0.54	25.3	12.4	1.25	.265	3.64	90	2.96	83	6.56	370.2
4	Walter Johnson W. Johnson	279	666	417	.401	802	.599	2.17	3,509	531	110	34	5914.1	4,913	1,424	1,902	97	1,363	205	127		23,405	154	5.34	2.07	2.57	0.15	15.0	5.8	1.06	.264	2.89	68	2.42	76	7.48	472.8
5	Phil Niekro P. Niekro	274	716	318	.463	864	.537	3.35	3,342	245	45	29	5404.0	5,044	2,012	2,337	482	1,809	123	83	86	22,677	226	5.57	3.01	1.85	0.80	14.7	8.0	1.27	.270	3.89	87	3.61	95	8.40	116.1
6	Gaylord Perry G. Perry	265	690	314	.458	777	.542	3.11	3,534	303	53	10	5350.0	4,938	1,846	2,128	399	1,379	108	33	164	21,953	160	5.95	2.32	2.56	0.67	16.1	6.3	1.18	.275	3.58	85	3.06	85	8.31	312.9
7	Don Sutton D. Sutton	256	756	324	.441	774	.559	3.26	3,574	178	58	5	5282.1	4,692	1,914	2,104	472	1,343	82	12	102	21,631	112	6.09	2.29	2.66	0.80	16.5	6.2	1.14	.261	3.58	92	3.23	90	7.99	181.2
8	Jack Powell J. Powell	254	516	245	.509	578	.491	2.97	1,621	422	46	15	4389.0	4,319	1,450	1,991	110	1,021	120	57		17,896	67	3.32	2.09	1.59	0.23	9.1	5.7	1.22	.280	4.08	95	3.01	97	8.86	35
9	Eppa Rixey E. Rixey	251	554	266	.485	692	.515	3.15	1,350	290	37	14	4494.2	4,633	1,572	1,986	93	1,082	76	99		18,754	97	2.70	2.17	1.25	0.19	7.2	5.8	1.27	.281	3.98	88	3.29	91	9.28	162.7
10	Bert Blyleven B. Blyleven	250	685	287	.466	692	.534	3.31	3,701	242	60	0	4970.0	4,632	1,830	2,029	430	1,322	155	3	71	20,491	114	6.70	2.39	2.80	0.78	18.1	6.5	1.20	.282	3.67	85	3.18	82	8.39	368.6
11	Robin Roberts R. Roberts	245	609	286	.461	676	.539	3.41	2,357	305	45	25	4688.2	4,582	1,774	1,962	505	902	54	49	69	19,174	33	4.52	1.73	2.61	0.97	12.3	4.7	1.17	.265	3.77	89	3.50	91	8.80	179.6
12	Warren Spahn W. Spahn	245	665	363	.403	750	.597	3.09	2,583	382	63	28	5243.2	4,830	1,798	2,016	434	1,434	42	67	60	21,547	81	4.43	2.46	1.80	0.74	12.0	6.7	1.19	.258	3.46	84	3.44	94	8.29	124.4
13	Steve Carlton S. Carlton	244	709	329	.426	741	.574	3.22	4,136	254	55	2	5217.2	4,672	1,864	2,130	414	1,833	53	13	150	21,683	183	7.13	3.16	2.26	0.71	19.1	8.5	1.25	.279	3.67	87	3.14	86	8.06	271.5
14	Early Wynn E. Wynn	244	611	300	.449	691	.551	3.54	2,334	289	49	16	4564.0	4,291	1,796	2,037	338	1,775	64	67	36	19,408	51	4.60	3.50	1.31	0.67	12.0	9.1	1.33	.265	4.02	94	3.64	97	8.46	56.4
15	Jim Kaat J. Kaat	237	625	283	.456	898	.544	3.45	2,461	180	31	17	4530.1	4,620	1,738	2,038	395	1,083	122	102	116	19,023	128	4.89	2.15	2.27	0.78	12.9	5.7	1.26	.282	4.05	93	3.41	91	9.18	165.8
16	Frank Tanana F. Tanana	236	616	240	.496	638	.504	3.66	2,773	143	34	1	4188.1	4,063	1,704	1,910	448	1,255	129	10	116	17,641	119	5.96	2.70	2.21	0.96	15.7	7.1	1.27	.277	4.10	94	3.78	96	8.73	66.4
17	Gus Weyhing G. Weyhing	232	505	264	.468	540	.532	3.88	1,667	449	28	4	4337.0	4,576	1,872	2,796	120	1,570	277	34		19,188	240	3.46	3.26	1.06	0.25	8.7	8.2	1.42	.286	5.80	96	3.82	97	9.50	55.7
18	Tommy John T. John	231	700	288	.445	760	.555	3.34	2,245	162	46	3	4710.1	4,783	1,749	2,017	302	1,259	98	22	102	19,692	187	4.29	2.41	1.78	0.58	11.4	6.4	1.28	.284	3.85	90	3.37	89	9.14	208.3
19	Bob Friend B. Friend	230	497	197	.539	602	.461	3.58	1,734	163	36	10	3611.0	3,772	1,438	1,652	286	894	46	56	115	15,214	50	4.32	2.23	1.94	0.71	11.4	5.9	1.29	.284	4.12	94	3.35	89	9.40	172.2
20	Ted Lyons T. Lyons	230	484	260	.469	594	.531	3.67	1,073	356	27	25	4161.0	4,489	1,696	2,056	222	1,121	31	91		17,797	55	2.32	2.42	0.96	0.48	6.0	6.3	1.35	.278	4.45	85	4.01	95	9.71	91.7
21	Greg Maddux G. Maddux	227	740	355	.390	744	.610	3.16	3,371	109	35	0	5008.1	4,726	1,756	1,981	353	999	137	3	177	20,421	70	6.06	1.80	3.37	0.63	16.5	4.9	1.14	.281	3.56	76	3.25	78	8.49	519.5
22	Fergie Jenkins F. Jenkins	226	594	284	.443	664	.557	3.34	3,192	267	49	7	4500.2	4,142	1,669	1,853	484	997	84	37	116	18,400	62	6.38	1.99	3.20	0.97	17.3	5.4	1.14	.268	3.71	87	3.27	88	8.28	222.9
23	Red Ruffing R. Ruffing	225	538	273	.452	624	.548	3.80	1,987	335	45	18	4344.0	4,284	1,833	2,115	254	1,541	58	69		18,546	46	4.12	3.19	1.29	0.53	10.7	8.3	1.34	.274	4.38	91	3.93	95	8.88	82.3
24	Tim Keefe T. Keefe	225	594	342	.397	600	.603	2.63	2,564	554	39	2	5049.2	4,438	1,474	2,470	75	1,233	83	7		20,941	240	4.57	2.20	2.08	0.13	12.2	5.9	1.12	.257	4.40	79	2.92	87	7.91	239.2
25	Bobo Newsom B. Newsom	222	483	211	.513	600	.487	3.98	2,082	246	31	21	3759.1	3,769	1,664	1,908	206	1,732	61	71		16,467	60	4.98	4.15	1.20	0.49	12.6	10.5	1.46	.288	4.57	95	3.81	92	9.02	144.5