Between the 2005 and 2021 seasons, Albert Pujols had the most games, with 2,342 games.

Interpreted as:

most regular-season games played by a player between 2005 to 2021

	NAME	G	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS	WRC	WRAA	WOBA	WRC+	BRAA
1	Albert Pujols A. Pujols	2,342	8,751	1,372	2,514	483	7	519	1,646	1,041	78	1,070	103	28	9,962	4,568	1,009	0	92	272	338	.287	.365	.522	.887	1599	425.5	.372	134	421.4
2	Miguel Cabrera M. Cabrera	2,340	8,708	1,365	2,726	545	13	457	1,630	1,106	61	1,698	34	17	9,962	4,668	1,015	1	86	227	310	.313	.391	.536	.927	1749	574.6	.392	145	535.4
3	Robinson Cano R. Cano	2,234	8,673	1,257	2,624	571	33	334	1,302	616	85	1,189	51	38	9,446	4,263	938	10	62	112	284	.303	.352	.492	.844	1411	303.4	.360	125	284.7
4	Nick Markakis N. Markakis	2,154	8,302	1,119	2,388	514	22	189	1,046	891	51	1,230	66	32	9,321	3,513	725	4	73	79	214	.288	.357	.423	.781	1244	152.2	.340	109	97.6
5	Yadier Molina Y. Molina	2,095	7,420	746	2,076	394	7	169	983	524	74	862	69	36	8,132	2,991	570	41	73	47	273	.280	.330	.403	.734	950	-7.3	.319	99	-18.8
6	Curtis Granderson C. Granderson	2,048	7,211	1,215	1,794	345	94	344	937	921	67	1,908	153	50	8,278	3,359	783	30	49	31	63	.249	.337	.466	.803	1146	173.8	.347	115	148.4
7	Ichiro Suzuki I. Suzuki	2,019	7,212	970	2,165	248	67	80	538	464	32	833	352	69	7,781	2,787	395	38	35	118	72	.300	.344	.386	.730	889	-24.5	.318	98	-18.1
8	Adrian Beltre A. Beltre	1,967	7,606	1,068	2,217	460	20	330	1,197	562	70	1,142	59	16	8,312	3,707	810	1	73	80	204	.291	.343	.487	.830	1199	228.1	.355	119	179.8
9	Edwin Encarnacion E. Encarnacion	1,960	7,040	1,099	1,832	370	10	424	1,261	903	105	1,426	61	14	8,114	3,494	804	0	66	54	185	.260	.350	.496	.846	1233	280.2	.362	125	235.4
10	Adrian Gonzalez A. Gonzalez	1,913	7,097	990	2,040	434	12	316	1,195	780	45	1,395	6	7	7,999	3,446	762	4	73	158	207	.287	.358	.486	.844	1182	250.4	.359	127	257.5
11	Joey Votto J. Votto	1,900	6,722	1,114	2,027	435	21	331	1,065	1,294	64	1,481	80	29	8,128	3,497	787	0	48	147	158	.302	.416	.520	.937	1489	538.2	.400	149	476.6
12	Ian Kinsler I. Kinsler	1,888	7,423	1,243	1,999	416	41	257	909	693	92	1,046	243	74	8,299	3,268	714	32	59	11	161	.269	.337	.440	.777	1093	125.8	.338	107	69.9
13	Melky Cabrera M. Cabrera	1,887	6,878	895	1,962	383	45	144	854	510	27	891	101	37	7,527	2,867	572	48	64	41	181	.285	.334	.417	.751	915	32.9	.326	101	6.8
14	Nelson Cruz N. Cruz	1,882	6,910	1,031	1,913	351	14	449	1,238	683	80	1,751	79	32	7,731	3,639	814	2	56	76	161	.277	.346	.527	.873	1229	324.4	.369	132	297.5
15	Justin Upton J. Upton	1,828	6,673	1,056	1,748	349	38	324	1,000	779	75	1,948	151	59	7,589	3,145	711	3	59	49	141	.262	.343	.471	.814	1079	197.7	.350	118	159.1
16	Evan Longoria E. Longoria	1,823	6,829	961	1,818	409	26	317	1,089	680	70	1,540	58	19	7,671	3,230	752	1	91	85	192	.266	.335	.473	.808	1053	160.6	.344	118	167.5
17	Adam Jones A. Jones	1,823	7,009	963	1,939	336	29	282	945	340	103	1,395	97	35	7,515	3,179	647	8	55	20	190	.277	.317	.454	.771	955	83.4	.332	105	44.6
18	Joe Mauer J. Mauer	1,823	6,823	1,000	2,090	420	29	137	906	928	24	1,020	51	19	7,838	2,979	586	6	57	145	207	.306	.388	.437	.825	1157	239.1	.358	122	214.6
19	Asdrubal Cabrera A. Cabrera	1,822	6,632	886	1,763	401	28	195	869	589	68	1,330	91	32	7,401	2,805	624	51	61	26	177	.266	.329	.423	.752	916	53.3	.327	104	37.8
20	Chase Utley C. Utley	1,800	6,456	1,054	1,782	390	55	244	947	698	196	1,131	148	21	7,424	3,014	689	5	69	61	84	.276	.361	.467	.828	1093	222	.358	120	185.2
21	Ryan Zimmerman R. Zimmerman	1,799	6,654	963	1,846	417	22	284	1,061	646	31	1,384	43	16	7,401	3,159	723	1	69	43	212	.277	.341	.475	.816	1046	173.6	.350	116	140.7
22	Elvis Andrus E. Andrus	1,798	6,863	953	1,864	328	50	79	673	547	50	1,043	317	107	7,619	2,529	457	103	56	7	175	.272	.327	.368	.696	821	-63.1	.307	85	-135.4
23	Matt Holliday M. Holliday	1,782	6,609	1,092	1,980	437	29	302	1,163	771	118	1,276	105	34	7,542	3,381	768	0	44	57	211	.300	.380	.512	.892	1267	383.9	.384	136	333.7
24	Brandon Phillips B. Phillips	1,773	6,955	963	1,940	345	33	205	913	401	88	1,004	205	77	7,538	2,966	583	33	61	34	211	.279	.324	.426	.750	907	26.9	.325	97	-25
25	Victor Martinez V. Martinez	1,771	6,586	820	1,951	380	2	221	1,049	654	47	799	6	5	7,365	2,998	603	0	78	108	239	.296	.360	.455	.815	1040	178.6	.351	117	150.9