Since 2000, Fernando Rodney has thrown in the most games, with 951 games.

Interpreted as:

most regular-season games by a player since 2000 pitcher

	NAME	G	W	L	W%	GS	ERA	SO	CG	SHO	SV	IP	H	ER	R	HR	BB	HBP	GF	IBB	TBF	WP	K/9	BB/9	K/BB	HR/9	K%	BB%	WHIP	BABIP	RA	ERA-	FIP	FIP-	H/9	PRAA
1	Fernando Rodney F. Rodney	951	48	71	.403	0	3.80	943	0	0	327	933.0	817	394	433	73	464	52	590	38	4,064	65	9.10	4.48	2.03	0.70	23.2	11.4	1.37	.294	4.18	91	3.76	90	7.88	43.6
2	Francisco Rodriguez F. Rodriguez	948	52	53	.495	0	2.86	1,142	0	0	437	976.0	738	310	336	98	389	17	677	42	4,011	68	10.53	3.59	2.94	0.90	28.5	9.7	1.15	.271	3.10	69	3.30	79	6.81	97
3	LaTroy Hawkins L. Hawkins	943	49	50	.495	0	3.28	684	0	0	127	946.0	927	345	377	77	267	10	372	32	3,947	43	6.51	2.54	2.56	0.73	17.3	6.8	1.26	.292	3.59	76	3.56	83	8.82	76.6
4	Kenley Jansen K. Jansen	897	50	38	.568	0	2.62	1,240	0	0	460	891.0	594	259	277	85	272	31	674	19	3,543	21	12.53	2.75	4.56	0.86	35.0	7.7	0.97	.266	2.80	66	2.61	64	6.00	142.1
5	Joe Smith J. Smith	866	55	34	.618	0	3.14	666	0	0	30	762.1	653	266	289	66	254	40	176	31	3,150	19	7.86	3.00	2.62	0.78	21.1	8.1	1.19	.276	3.41	77	3.65	89	7.71	39
6	Kyle Farnsworth K. Farnsworth	866	38	57	.400	5	4.14	893	0	0	57	858.2	804	395	429	104	360	25	292	36	3,702	36	9.36	3.77	2.48	1.09	24.1	9.7	1.36	.302	4.50	97	3.91	91	8.43	37.1
7	David Robertson D. Robertson	861	66	46	.589	1	2.91	1,154	0	0	177	876.2	656	283	306	77	357	25	354	37	3,612	57	11.85	3.67	3.23	0.79	31.9	9.9	1.16	.290	3.14	70	2.94	69	6.73	123.6
8	Mariano Rivera M. Rivera	849	56	47	.544	0	2.05	836	0	0	523	907.0	698	207	227	49	167	38	768	28	3,562	8	8.30	1.66	5.01	0.49	23.5	4.7	0.95	.263	2.25	46	2.61	59	6.93	180.9
9	Chad Qualls C. Qualls	844	52	48	.520	0	3.89	624	0	0	74	807.1	819	349	382	83	211	32	274	42	3,397	28	6.96	2.35	2.96	0.93	18.4	6.2	1.28	.301	4.26	94	3.79	91	9.13	34.9
10	Javier Lopez J. Lopez	839	30	17	.638	0	3.48	358	0	0	14	533.1	484	206	227	26	235	27	163	38	2,273	16	6.04	3.97	1.52	0.44	15.8	10.3	1.35	.281	3.83	82	3.85	95	8.17	10.5
11	Craig Kimbrel C. Kimbrel	838	56	47	.544	0	2.59	1,266	0	0	440	810.2	483	233	259	73	340	40	651	11	3,260	70	14.06	3.77	3.72	0.81	38.8	10.4	1.02	.266	2.88	63	2.58	63	5.36	131.9
12	Aroldis Chapman A. Chapman	828	58	46	.558	0	2.59	1,285	0	0	347	789.0	463	227	252	53	402	33	538	7	3,225	82	14.66	4.59	3.20	0.60	39.8	12.5	1.10	.282	2.87	63	2.40	58	5.28	151.1
13	Sergio Romo S. Romo	821	42	36	.538	5	3.21	789	0	0	137	722.2	579	258	275	85	179	27	301	21	2,919	22	9.83	2.23	4.41	1.06	27.0	6.1	1.05	.269	3.42	82	3.32	84	7.21	50.2
14	Tyler Clippard T. Clippard	807	56	48	.538	14	3.16	956	0	0	74	872.1	625	306	327	112	344	32	212	19	3,575	48	9.86	3.55	2.78	1.16	26.7	9.6	1.11	.241	3.37	77	3.88	95	6.45	18.9
15	Bryan Shaw B. Shaw	796	43	46	.483	2	3.96	681	0	0	19	764.1	723	336	377	82	299	32	172	21	3,270	41	8.02	3.52	2.28	0.97	20.8	9.1	1.34	.295	4.44	93	4.05	97	8.51	9.3
16	Francisco Cordero F. Cordero	780	45	51	.469	0	3.38	777	0	0	329	805.2	732	303	335	62	357	27	571	28	3,460	36	8.68	3.99	2.18	0.69	22.5	10.3	1.35	.300	3.74	75	3.58	81	8.18	77.2
17	Jeremy Affeldt J. Affeldt	774	43	46	.483	42	3.97	720	0	0	28	926.0	904	408	455	76	396	42	162	41	4,034	55	7.00	3.85	1.82	0.74	17.8	9.8	1.40	.296	4.42	92	4.00	95	8.79	21.3
18	Joakim Soria J. Soria	773	36	45	.444	1	3.11	831	0	0	229	763.0	633	264	279	67	231	27	427	18	3,146	33	9.80	2.72	3.60	0.79	26.4	7.3	1.13	.284	3.29	73	3.11	74	7.47	92.7
19	Joe Nathan J. Nathan	768	57	30	.655	15	2.72	922	0	0	376	833.0	606	252	272	67	298	22	585	31	3,376	45	9.96	3.22	3.09	0.72	27.3	8.8	1.09	.261	2.94	64	3.07	73	6.55	107.5
20	Joaquin Benoit J. Benoit	764	58	49	.542	55	3.83	1,058	0	0	53	1068.2	883	455	485	129	437	32	185	21	4,498	38	8.91	3.68	2.42	1.09	23.5	9.7	1.24	.265	4.08	85	3.98	92	7.44	39.4
21	Matt Thornton M. Thornton	748	36	46	.439	1	3.41	642	0	0	23	662.2	594	251	273	52	251	20	170	37	2,799	28	8.72	3.41	2.56	0.71	22.9	9.0	1.28	.296	3.71	79	3.40	79	8.07	66.8
22	Ryan Madson R. Madson	740	61	48	.560	18	3.48	775	0	0	91	869.2	830	336	358	82	250	44	236	44	3,631	40	8.02	2.59	3.10	0.85	21.3	6.9	1.24	.302	3.70	81	3.56	82	8.59	72.4
23	Brad Ziegler B. Ziegler	739	37	38	.493	0	2.75	479	0	0	105	717.1	654	219	251	32	248	25	264	55	2,947	7	6.01	3.11	1.93	0.40	16.3	8.4	1.26	.288	3.15	68	3.49	87	8.21	41.9
24	Octavio Dotel O. Dotel	739	51	47	.520	20	3.62	1,058	0	0	109	865.2	696	348	379	105	363	35	304	38	3,656	43	11.00	3.77	2.91	1.09	28.9	9.9	1.22	.282	3.94	82	3.57	81	7.24	77.8
25	Steve Cishek S. Cishek	737	33	43	.434	0	2.98	743	0	0	133	710.2	565	235	264	54	288	59	312	38	2,993	29	9.41	3.65	2.58	0.68	24.8	9.6	1.20	.276	3.34	75	3.48	86	7.16	41.6