Between the 2012 and 2021 seasons, Jon Lester and Max Scherzer were tied for starting the most games, with 297 starts.

Interpreted as:

most regular-season games started by a player 2012 to 2021

	NAME	GS	G	W	L	W%	ERA	SO	CG	SHO	SV	IP	H	ER	R	HR	BB	HBP	GF	IBB	TBF	WP	K/9	BB/9	K/BB	HR/9	K%	BB%	WHIP	BABIP	RA	ERA-	FIP	FIP-	H/9	PRAA
1	Jon Lester J. Lester	297	297	124	83	.599	3.73	1,594	9	2	0	1782.1	1,737	738	823	209	530	50	0	11	7,468	38	8.05	2.68	3.01	1.06	21.3	7.1	1.27	.300	4.16	89	3.84	94	8.77	43.5
2	Max Scherzer M. Scherzer	297	297	154	62	.713	2.91	2,422	12	5	0	1919.2	1,477	621	656	213	467	67	0	16	7,655	46	11.36	2.19	5.19	1.00	31.6	6.1	1.01	.282	3.08	70	2.89	70	6.92	264.1
3	Zack Greinke Z. Greinke	291	292	143	59	.708	3.13	1,677	5	2	0	1830.1	1,610	636	672	197	387	29	0	13	7,336	57	8.25	1.90	4.33	0.97	22.9	5.3	1.09	.280	3.30	77	3.38	84	7.92	133.5
4	Wade Miley W. Miley	270	275	93	90	.508	4.14	1,227	3	2	0	1541.0	1,584	709	757	169	531	39	2	10	6,605	54	7.17	3.10	2.31	0.99	18.6	8.0	1.37	.305	4.42	100	4.07	99	9.25	7.6
5	Madison Bumgarner M. Bumgarner	269	269	107	87	.552	3.35	1,661	16	7	0	1708.1	1,474	636	692	204	405	69	0	30	6,954	26	8.75	2.13	4.10	1.07	23.9	5.8	1.10	.275	3.65	86	3.57	93	7.77	49.1
6	Lance Lynn L. Lynn	262	270	114	76	.600	3.49	1,551	4	2	0	1549.0	1,410	601	648	149	563	65	2	19	6,553	50	9.01	3.27	2.75	0.87	23.7	8.6	1.27	.298	3.77	86	3.60	88	8.19	86.7
7	Rick Porcello R. Porcello	262	266	112	95	.541	4.35	1,284	10	3	0	1581.0	1,696	765	842	201	353	66	2	14	6,708	41	7.31	2.01	3.64	1.14	19.1	5.3	1.30	.311	4.79	101	3.96	95	9.65	34
8	Clayton Kershaw C. Kershaw	260	261	138	56	.711	2.33	1,925	19	12	0	1738.1	1,297	450	496	150	328	25	0	9	6,736	67	9.97	1.70	5.87	0.78	28.6	4.9	0.93	.266	2.57	60	2.64	66	6.72	261.6
9	Jose Quintana J. Quintana	257	283	83	80	.509	3.84	1,395	2	2	0	1558.0	1,544	664	717	166	457	38	7	22	6,541	64	8.06	2.64	3.05	0.96	21.3	7.0	1.28	.307	4.14	93	3.68	88	8.92	86.2
10	J.A. Happ	256	266	108	76	.587	4.16	1,307	0	0	0	1448.1	1,408	670	706	206	466	32	5	7	6,132	37	8.12	2.90	2.80	1.28	21.3	7.6	1.29	.292	4.39	100	4.21	101	8.75	-3.4
11	Justin Verlander J. Verlander	255	255	119	72	.623	3.16	1,798	12	4	0	1672.2	1,377	588	637	192	441	43	0	10	6,762	32	9.67	2.37	4.08	1.03	26.6	6.5	1.09	.276	3.43	76	3.34	80	7.41	157.6
12	Mike Leake M. Leake	248	248	85	85	.500	4.06	1,022	6	2	0	1523.0	1,623	687	754	196	316	57	0	24	6,396	29	6.04	1.87	3.23	1.16	16.0	4.9	1.27	.297	4.46	101	4.19	103	9.59	-22.8
13	Dallas Keuchel D. Keuchel	243	254	99	82	.547	3.77	1,173	12	4	0	1527.1	1,500	640	691	158	458	37	2	9	6,401	55	6.91	2.70	2.56	0.93	18.3	7.2	1.28	.293	4.07	92	3.92	95	8.84	38.6
14	Cole Hamels C. Hamels	242	242	89	68	.567	3.45	1,469	7	3	0	1536.2	1,391	589	639	169	475	75	0	17	6,380	40	8.60	2.78	3.09	0.99	23.0	7.4	1.21	.292	3.74	83	3.72	90	8.15	70.2
15	Chris Sale C. Sale	241	242	110	71	.608	3.06	1,948	16	3	0	1578.0	1,290	536	582	170	349	100	0	12	6,347	35	11.11	1.99	5.58	0.97	30.7	5.5	1.04	.296	3.32	72	2.91	69	7.36	226
16	Jake Arrieta J. Arrieta	239	245	99	79	.556	3.84	1,288	6	5	0	1392.2	1,229	594	660	151	464	56	1	18	5,783	74	8.32	3.00	2.78	0.98	22.3	8.0	1.22	.282	4.27	93	3.82	92	7.94	48.2
17	Gio Gonzalez G. Gonzalez	239	249	93	69	.574	3.61	1,349	3	2	0	1397.2	1,253	561	599	116	551	34	1	16	5,909	46	8.69	3.55	2.45	0.75	22.8	9.3	1.29	.295	3.86	89	3.53	88	8.07	75.6
18	Adam Wainwright A. Wainwright	239	243	118	70	.628	3.57	1,280	19	9	0	1501.1	1,432	596	632	133	392	50	2	29	6,205	24	7.67	2.35	3.27	0.80	20.6	6.3	1.21	.299	3.79	90	3.46	86	8.58	86.9
19	Jeff Samardzija J. Samardzija	236	236	68	97	.412	4.12	1,307	9	4	0	1475.2	1,400	676	720	189	391	51	0	18	6,126	47	7.97	2.38	3.34	1.15	21.3	6.4	1.21	.289	4.39	104	3.92	99	8.54	3.9
20	Gerrit Cole G. Cole	234	234	117	63	.650	3.20	1,673	6	3	0	1449.1	1,238	515	557	153	373	46	0	6	5,857	52	10.39	2.32	4.49	0.95	28.6	6.4	1.11	.300	3.46	79	3.08	75	7.69	168.1
21	David Price D. Price	233	266	114	56	.671	3.32	1,519	15	2	1	1528.0	1,402	563	614	160	353	44	6	8	6,247	31	8.95	2.08	4.30	0.94	24.3	5.7	1.15	.298	3.62	80	3.28	80	8.26	136.6
22	Julio Teheran J. Teheran	233	235	77	76	.503	3.79	1,197	5	3	0	1376.2	1,211	579	624	185	469	67	0	22	5,742	26	7.83	3.07	2.55	1.21	20.8	8.2	1.22	.268	4.08	93	4.31	109	7.92	-56.3
23	Kyle Gibson K. Gibson	230	236	79	83	.488	4.45	1,058	3	1	0	1336.1	1,373	661	708	156	486	49	0	14	5,749	54	7.13	3.27	2.18	1.05	18.4	8.5	1.39	.304	4.77	105	4.28	101	9.25	-3.9
24	Patrick Corbin P. Corbin	229	247	81	84	.491	4.09	1,338	5	2	2	1385.0	1,390	629	677	178	419	34	9	21	5,879	50	8.69	2.72	3.19	1.16	22.8	7.1	1.31	.310	4.40	97	3.86	93	9.03	45.5
25	Stephen Strasburg S. Strasburg	229	229	107	57	.652	3.26	1,602	2	2	0	1373.1	1,138	497	545	143	373	52	0	20	5,577	41	10.50	2.44	4.29	0.94	28.7	6.7	1.10	.292	3.57	81	3.08	77	7.46	145.2