Nolan Ryan had the most games pitched when his Game Score was 20+, with 760 games.

Interpreted as:

most regular-season games by a player with a 20 or more game score

	NAME	G	W	L	W%	GS	ERA	SO	CG	SHO	SV	IP	H	ER	R	HR	BB	HBP	GF	IBB	TBF	WP	K/9	BB/9	K/BB	HR/9	K%	BB%	WHIP	BABIP	RA	H/9
1	Nolan Ryan N. Ryan	760	318	278	.534	760	3.05	5,624	222	61	0	5291.1	3,787	1,792	2,058	299	2,710	155	0	75	22,084	271	9.57	4.61	2.08	0.51	25.5	12.3	1.23	.262	3.50	6.44
2	Don Sutton D. Sutton	734	319	236	.575	734	3.04	3,501	178	58	0	5178.2	4,484	1,752	1,938	448	1,285	79	0	94	21,060	109	6.08	2.23	2.72	0.78	16.6	6.1	1.11	.256	3.37	7.79
3	Greg Maddux G. Maddux	718	355	208	.631	718	2.92	3,307	109	35	0	4917.1	4,499	1,596	1,807	329	955	134	0	164	19,879	68	6.05	1.75	3.46	0.60	16.6	4.8	1.11	.275	3.31	8.23
4	Phil Niekro P. Niekro	698	302	248	.549	698	3.20	3,157	245	45	0	5095.2	4,668	1,810	2,104	449	1,664	114	0	72	21,237	203	5.58	2.94	1.90	0.79	14.9	7.8	1.24	.266	3.72	8.24
5	Roger Clemens R. Clemens	690	354	173	.672	690	2.93	4,618	118	46	0	4849.1	4,023	1,581	1,749	341	1,531	157	0	61	19,828	138	8.57	2.84	3.02	0.63	23.3	7.7	1.15	.279	3.25	7.47
6	Steve Carlton S. Carlton	689	327	224	.593	689	2.99	4,067	254	55	0	5095.2	4,442	1,692	1,942	372	1,769	51	0	142	21,023	171	7.18	3.12	2.30	0.66	19.3	8.4	1.22	.276	3.43	7.85
7	Tommy John T. John	679	284	208	.577	679	3.12	2,175	162	46	0	4550.2	4,509	1,577	1,828	283	1,181	91	0	93	18,880	168	4.30	2.34	1.84	0.56	11.5	6.3	1.25	.279	3.62	8.92
8	Gaylord Perry G. Perry	671	305	235	.565	671	2.91	3,339	303	53	0	5098.0	4,605	1,647	1,910	364	1,274	97	0	136	20,779	142	5.89	2.25	2.62	0.64	16.1	6.1	1.15	.270	3.37	8.13
9	Bert Blyleven B. Blyleven	670	286	233	.551	670	3.15	3,666	242	60	0	4908.1	4,489	1,717	1,912	404	1,292	152	0	62	20,135	108	6.72	2.37	2.84	0.74	18.2	6.4	1.18	.279	3.51	8.23
10	Warren Spahn W. Spahn	659	358	223	.616	659	3.02	2,495	382	63	0	5083.0	4,653	1,706	1,912	415	1,374	38	0	52	20,848	74	4.42	2.43	1.82	0.73	12.0	6.6	1.19	.256	3.39	8.24
11	Tom Glavine T. Glavine	656	305	182	.626	656	3.24	2,570	56	25	0	4326.1	4,074	1,557	1,717	331	1,424	64	0	141	18,059	63	5.35	2.96	1.80	0.69	14.2	7.9	1.27	.274	3.57	8.48
12	Tom Seaver T. Seaver	636	310	193	.616	636	2.74	3,611	231	61	0	4745.2	3,864	1,443	1,592	368	1,356	76	0	110	19,123	120	6.85	2.57	2.66	0.70	18.9	7.1	1.10	.255	3.02	7.33
13	Jim Kaat J. Kaat	616	260	210	.553	616	3.33	2,290	180	31	0	4111.0	4,122	1,521	1,791	362	945	111	0	75	17,167	115	5.01	2.07	2.42	0.79	13.3	5.5	1.23	.279	3.92	9.02
14	Jamie Moyer J. Moyer	610	262	184	.587	610	3.91	2,299	33	10	0	3842.1	3,857	1,669	1,804	459	1,049	130	0	59	16,187	46	5.39	2.46	2.19	1.08	14.2	6.5	1.28	.277	4.23	9.03
15	Frank Tanana F. Tanana	605	236	225	.512	605	3.54	2,720	143	34	0	4113.2	3,937	1,620	1,824	427	1,213	128	0	109	17,253	113	5.95	2.65	2.24	0.93	15.8	7.0	1.25	.275	3.99	8.61
16	Robin Roberts R. Roberts	597	275	229	.546	597	3.28	2,271	305	45	0	4528.0	4,371	1,650	1,824	482	848	54	0	61	18,486	32	4.51	1.69	2.68	0.96	12.3	4.6	1.15	.262	3.63	8.69
17	Early Wynn E. Wynn	590	287	214	.573	590	3.33	2,215	288	49	0	4304.1	3,920	1,594	1,817	313	1,650	61	0	30	18,155	49	4.63	3.45	1.34	0.65	12.2	9.1	1.29	.259	3.80	8.20
18	Randy Johnson R. Johnson	587	301	152	.664	587	3.07	4,772	100	37	0	4048.0	3,198	1,380	1,562	392	1,435	182	0	35	16,595	105	10.61	3.19	3.33	0.87	28.8	8.6	1.14	.286	3.47	7.11
19	Fergie Jenkins F. Jenkins	581	278	211	.569	581	3.18	3,064	267	49	0	4318.1	3,909	1,527	1,702	453	931	82	0	98	17,563	59	6.39	1.94	3.29	0.94	17.4	5.3	1.12	.265	3.55	8.15
20	Grover Alexander G. Alexander	565	336	176	.656	565	2.40	1,952	416	90	0	4699.1	4,345	1,253	1,562	148	792	56	0		18,835	30	3.74	1.52	2.46	0.28	10.4	4.2	1.09	.264	2.99	8.32
21	Dennis Martinez D. Martinez	550	230	173	.571	550	3.49	1,974	122	30	0	3700.0	3,537	1,434	1,617	335	1,047	112	0	59	15,408	68	4.80	2.55	1.89	0.81	12.8	6.8	1.24	.268	3.93	8.60
22	CC Sabathia	546	251	149	.628	546	3.53	3,060	38	12	0	3523.0	3,281	1,381	1,515	367	1,063	120	0	40	14,667	70	7.82	2.72	2.88	0.94	20.9	7.2	1.23	.290	3.87	8.38
23	Eppa Rixey E. Rixey	541	247	227	.521	541	2.99	1,226	288	37	0	4116.2	4,204	1,367	1,741	76	957	71	0		17,110	81	2.68	2.09	1.28	0.17	7.2	5.6	1.25	.279	3.81	9.19
24	Jerry Reuss J. Reuss	530	212	172	.552	530	3.38	1,800	127	39	0	3482.1	3,458	1,309	1,510	215	1,041	54	0	95	14,659	101	4.65	2.69	1.73	0.56	12.3	7.1	1.29	.281	3.90	8.94
25	Justin Verlander J. Verlander	527	262	141	.650	527	3.13	3,438	26	9	0	3436.2	2,849	1,194	1,293	347	954	114	0	26	13,964	94	9.00	2.50	3.60	0.91	24.6	6.8	1.11	.275	3.39	7.46