Between the 2001 and 2016 seasons, Albert Pujols hit the most homers, with 591 homers.

Interpreted as:

most home runs by a player 2001 to 2016

	NAME	HR	G	AB	R	H	2B	3B	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS	wRC	WRAA	wOBA	wRC+	BRAA
1	Albert Pujols A. Pujols	591	2,426	9,138	1,670	2,825	602	16	1,817	1,214	100	1,053	107	41	10,552	5,232	1,209	1	99	302	336	.309	.392	.573	.965	1951	704	.403	153	694.3
2	David Ortiz D. Ortiz	521	2,167	7,878	1,302	2,262	573	18	1,653	1,216	33	1,566	15	9	9,211	4,434	1,112	2	82	204	212	.287	.381	.563	.944	1638	550.4	.396	143	481.6
3	Alex Rodriguez A. Rodriguez	507	1,994	7,440	1,394	2,149	354	18	1,491	1,028	145	1,671	196	40	8,692	4,060	879	0	79	88	198	.289	.382	.546	.928	1543	501.9	.394	142	455
4	Adam Dunn A. Dunn	462	2,001	6,883	1,097	1,631	334	10	1,168	1,317	86	2,379	63	25	8,328	3,371	806	2	40	122	100	.237	.364	.490	.854	1285	297.9	.367	123	240
5	Miguel Cabrera M. Cabrera	446	2,096	7,853	1,321	2,519	523	17	1,553	1,011	57	1,516	38	20	9,001	4,414	986	5	75	220	279	.321	.399	.562	.961	1662	605.3	.405	153	569.1
6	Mark Teixeira M. Teixeira	409	1,862	6,936	1,099	1,862	408	18	1,298	918	111	1,441	26	7	8,029	3,533	835	0	64	91	158	.268	.360	.509	.869	1268	317.6	.371	127	262.4
7	Alfonso Soriano A. Soriano	409	1,944	7,692	1,145	2,085	478	31	1,155	495	86	1,785	287	83	8,334	3,852	918	7	54	68	123	.271	.320	.501	.821	1161	167.3	.349	111	118.3
8	Adrian Beltre A. Beltre	403	2,353	9,052	1,255	2,604	525	29	1,397	644	76	1,362	86	29	9,857	4,396	957	5	80	94	238	.288	.337	.486	.823	1393	229.3	.352	117	195
9	Carlos Beltran C. Beltran	392	2,189	8,208	1,349	2,315	489	64	1,377	967	43	1,489	269	41	9,323	4,108	945	16	89	97	163	.282	.357	.500	.858	1433	328	.366	125	287.4
10	Paul Konerko P. Konerko	387	1,983	7,132	986	1,985	344	3	1,205	812	89	1,209	7	3	8,108	3,496	734	0	75	80	230	.278	.356	.490	.846	1223	257.6	.363	120	203.2
11	Ryan Howard R. Howard	382	1,572	5,707	848	1,475	277	21	1,194	709	59	1,843	12	5	6,530	2,940	680	0	55	154	116	.258	.343	.515	.859	976	212.1	.361	121	175.3
12	Jim Thome J. Thome	379	1,469	4,788	868	1,295	237	9	1,014	983	36	1,495	2	9	5,847	2,687	625	0	40	119	93	.270	.396	.561	.957	1077	368.3	.403	146	337.1
13	Aramis Ramirez A. Ramirez	374	2,031	7,575	1,054	2,169	469	20	1,351	599	118	1,121	29	17	8,373	3,800	863	0	81	58	221	.286	.345	.502	.846	1256	263.9	.362	119	197.9
14	Lance Berkman L. Berkman	341	1,731	6,045	1,060	1,778	392	29	1,152	1,133	65	1,206	75	45	7,290	3,251	762	1	46	159	139	.294	.408	.538	.946	1335	457.5	.402	145	416.3
15	Torii Hunter T. Hunter	339	2,131	8,120	1,200	2,256	466	30	1,310	615	89	1,595	181	89	8,893	3,799	835	5	64	49	239	.278	.333	.468	.801	1209	159.2	.345	113	139.6
16	Prince Fielder P. Fielder	319	1,611	5,821	862	1,645	321	10	1,028	847	124	1,155	18	11	6,853	2,943	650	0	61	164	158	.283	.382	.506	.887	1112	311.9	.377	133	275
17	Manny Ramirez M. Ramirez	319	1,335	4,774	879	1,488	310	9	1,027	788	72	1,033	10	9	5,679	2,773	638	0	45	169	145	.312	.413	.581	.994	1108	416.2	.416	154	386.9
18	Andruw Jones A. Jones	318	1,530	5,264	825	1,298	254	15	928	653	71	1,280	57	26	6,045	2,536	587	0	57	48	146	.247	.334	.482	.816	844	110.4	.349	110	78.6
19	Carlos Lee C. Lee	318	1,820	6,919	952	1,957	408	15	1,187	604	40	818	108	41	7,650	3,349	741	1	86	59	178	.283	.340	.484	.824	1088	168.3	.352	114	134.3
20	Vladimir Guerrero V. Guerrero	313	1,575	5,999	971	1,895	353	21	1,092	563	74	712	144	64	6,686	3,229	687	0	50	198	217	.316	.379	.538	.917	1132	324.1	.384	134	288.4
21	Edwin Encarnacion E. Encarnacion	310	1,513	5,409	829	1,439	311	8	942	662	81	1,004	56	13	6,202	2,696	629	0	50	46	146	.266	.352	.498	.850	945	225.5	.365	126	187.6
22	Jose Bautista J. Bautista	308	1,519	5,139	878	1,311	267	17	862	881	66	1,113	60	26	6,159	2,536	592	23	50	53	152	.255	.368	.493	.861	967	253.3	.372	132	224.8
23	Adrian Gonzalez A. Gonzalez	308	1,804	6,739	968	1,954	415	12	1,146	751	44	1,324	6	6	7,605	3,317	735	4	67	154	195	.290	.362	.492	.854	1147	262.4	.363	129	269.3
24	Matt Holliday M. Holliday	295	1,773	6,583	1,104	1,995	448	32	1,153	744	121	1,230	107	37	7,489	3,392	775	1	40	57	206	.303	.382	.515	.897	1270	392	.386	137	335.3
25	Curtis Granderson C. Granderson	293	1,649	6,127	1,039	1,564	283	89	801	758	56	1,589	145	44	7,013	2,904	665	29	43	27	53	.255	.340	.474	.814	993	174.4	.352	118	150.6