Vladimir Guerrero Jr. has hit the most career homers by a 22-year-old player, with 48 homers.

Interpreted as:

most home runs by a player by a 22 year old

	NAME	HR	G	AB	R	H	2B	3B	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Vladimir Guerrero Jr. V. Guerrero Jr.	48	161	604	123	188	29	1	111	86	6	110	4	1	698	363	78	0	2	7	20	.311	.401	.601	1.002
2	Joe DiMaggio J. DiMaggio	46	151	621	151	215	35	15	167	64	5	37	3		692	418	96	2				.346	.412	.673	1.085
3	Johnny Bench J. Bench	45	158	605	97	177	35	4	148	54	0	102	5	2	671	355	84	1	11	9	12	.293	.345	.587	.932
4	Gunnar Henderson G. Henderson	43	162	652	134	180	34	10	110	69	8	163	18	2	734	363	87	0	5	1	6	.276	.350	.557	.907
5	Juan Gonzalez J. Gonzalez	43	155	584	77	152	24	2	109	35	5	143	0	1	632	309	69	0	8	1	16	.260	.304	.529	.833
6	Fernando Tatis Jr. F. Tatis Jr.	42	130	478	99	135	31	0	97	62	2	153	25	4	546	292	73	0	4	6	5	.282	.364	.611	.975
7	Bryce Harper B. Harper	42	153	521	118	172	38	1	99	124	5	131	6	4	654	338	81	0	4	15	15	.330	.460	.649	1.109
8	Eddie Mathews E. Mathews	40	138	476	96	138	21	4	103	112	2	61	10	3	600	287	65	3	7		9	.290	.422	.603	1.025
9	Alex Rodriguez A. Rodriguez	39	156	655	108	190	28	5	115	41	11	128	37	13	714	345	72	4	3	0	13	.290	.341	.527	.868
10	Gleyber Torres G. Torres	38	144	546	96	152	26	0	90	48	3	129	5	2	604	292	64	1	6	3	10	.278	.337	.535	.871
11	Giancarlo Stanton G. Stanton	37	123	449	75	130	30	1	86	46	5	143	6	2	501	273	68	0	1	9	5	.290	.361	.608	.969
12	Jimmie Foxx J. Foxx	37	153	562	127	188	33	13	156	93	0	66	7		674	358	83	19				.335	.429	.637	1.066
13	Nick Kurtz N. Kurtz	36	117	420	90	122	26	2	86	63	2	151	2	1	488	260	64	0	3	3	4	.290	.383	.619	1.002
14	Reggie Jackson R. Jackson	35	154	526	93	130	15	5	83	68	5	161	18	4	604	260	55	3	2	8	3	.247	.338	.494	.832
15	Boog Powell B. Powell	35	140	464	71	131	21	0	96	68	1	99	0	0	537	257	56	2	2	8	12	.282	.374	.554	.928
16	Albert Pujols A. Pujols	34	157	590	118	185	40	2	127	72	9	69	2	4	675	331	76	0	4	13	20	.314	.394	.561	.955
17	Bob Horner B. Horner	34	112	425	67	116	9	1	80	21	0	53	0	1	449	229	44	0	3	3	15	.273	.305	.539	.844
18	Ted Williams T. Williams	34	146	495	134	194	30	6	121	128	3	33	3		626	338	70	0			13	.392	.519	.683	1.202
19	Rougned Odor R. Odor	33	150	605	89	164	33	4	88	19	4	135	14	7	632	304	70	0	4	0	6	.271	.296	.502	.798
20	Mike Trout M. Trout	33	155	581	108	175	40	6	110	104	7	172	21	3	701	326	79	0	9	5	6	.301	.408	.561	.969
21	Prince Fielder P. Fielder	33	158	578	85	151	34	1	92	62	15	124	4	4	664	286	68	0	9	8	16	.261	.343	.495	.838
22	Frank Robinson F. Robinson	33	150	565	91	161	23	6	80	59	7	88	8	2	634	295	62	2	1	5	11	.285	.359	.522	.881
23	Julio Rodríguez J. Rodríguez	32	155	654	102	180	37	2	103	47	11	175	37	10	714	317	71	0	2	6	14	.275	.333	.485	.818
24	Rafael Devers R. Devers	32	156	647	129	201	54	4	115	48	4	119	8	8	702	359	90	1	2	7	8	.311	.361	.555	.916
25	Miguel Cabrera M. Cabrera	32	158	611	106	199	48	2	114	66	2	127	2	1	683	347	82	0	4	13	18	.326	.391	.568	.959

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Some of the information used here was obtained free of charge from Retrosheet.

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Fri 3/27	ATH	@	TOR	7:07 PM
Sat 3/28	ATH	@	TOR	3:07 PM
Sun 3/29	ATH	@	TOR	1:37 PM
Mon 3/30	COL	@	TOR	7:07 PM
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Braves	76	86	.469	20.0
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Tue 9/16	ATL	@	WSH	9-4
Tue 9/16	ATH	@	BOS	4-5
Tue 9/16	TOR	@	TBR	1-2
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Wed 3/25	NYY	@	SFG	8:05 PM
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Vladimir Guerrero Jr. has hit the most career homers by a 22-year-old player, with 48 homers.

Interpreted as:

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