Greg Vaughn has launched the most home runs for the Padres in a season, with 50 homers in 1998.

	NAME	HR	SEASON	TM	G	AB	R	H	2B	3B	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS	WRC	WRAA	WOBA	WRC+	BRAA
1	Greg Vaughn G. Vaughn	50	1998	SDP	158	573	112	156	28	4	119	79	5	121	11	4	661	342	82	0	4	6	7	.272	.363	.597	.960	121	39.6	.403	151	42.7
2	Fernando Tatis Jr. F. Tatis Jr.	42	2021	SDP	130	478	99	135	31	0	97	62	2	153	25	4	546	292	73	0	4	6	5	.282	.364	.611	.975	106	39.9	.403	158	40.4
3	Phil Nevin P. Nevin	41	2001	SDP	149	546	97	167	31	0	126	71	4	147	4	4	624	321	72	0	3	7	13	.306	.388	.588	.976	120	42.9	.408	154	44.2
4	Adrian Gonzalez A. Gonzalez	40	2009	SDP	160	552	90	153	27	2	99	119	5	109	1	1	681	304	69	1	4	22	23	.277	.407	.551	.958	124	42.1	.404	156	47.3
5	Ken Caminiti K. Caminiti	40	1996	SDP	146	546	109	178	37	2	130	78	4	99	11	5	638	339	79	0	10	16	15	.326	.408	.621	1.028	132	49.6	.426	169	56
6	Nate Colbert N. Colbert	38	1972	SDP	151	563	87	141	27	2	111	70	2	127	15	6	643	286	67	3	5	14	12	.250	.333	.508	.841	95	32	.374	139	27.7
7	Nate Colbert N. Colbert	38	1970	SDP	156	572	84	148	17	6	86	56	4	150	3	5	636	291	61	1	3	8	11	.259	.328	.509	.836	94	22.5	.365	123	18.2
8	Adrian Gonzalez A. Gonzalez	36	2008	SDP	162	616	103	172	32	1	119	74	7	142	0	0	700	314	69	0	3	18	24	.279	.361	.510	.871	108	23.7	.369	131	26.8
9	Juan Soto J. Soto	35	2023	SDP	162	568	97	156	32	1	109	132	2	129	12	5	708	295	68	1	5	11	18	.275	.410	.519	.930	131	45	.395	154	47
10	Fred McGriff F. McGriff	35	1992	SDP	152	531	79	152	30	4	104	96	1	108	8	6	632	295	69	0	4	23	14	.286	.394	.556	.950	113	44.8	.411	163	43.2
11	Phil Plantier P. Plantier	34	1993	SDP	138	462	67	111	20	1	100	61	7	124	4	5	536	235	55	1	5	7	4	.240	.335	.509	.843	80	15.8	.363	121	13.7
12	Dave Winfield D. Winfield	34	1979	SDP	159	597	97	184	27	10	118	85	2	71	15	9	686	333	71	0	2	24	9	.308	.395	.558	.953	125	45.1	.407	160	49
13	Hunter Renfroe H. Renfroe	33	2019	SDP	140	440	64	95	19	1	64	46	2	154	5	0	494	215	53	0	6	1	6	.216	.289	.489	.778	62	0	.320	99	-0.6
14	Gary Sheffield G. Sheffield	33	1992	SDP	146	557	87	184	34	3	100	48	6	40	5	6	618	323	70	0	7	5	19	.330	.385	.580	.965	117	50.1	.425	172	48.6
15	Manny Machado M. Machado	32	2022	SDP	150	578	100	172	37	1	102	63	1	133	9	1	644	307	70	0	2	10	12	.298	.366	.531	.898	110	36.8	.382	153	40
16	Manny Machado M. Machado	32	2019	SDP	156	587	81	150	21	2	85	65	6	128	5	3	661	271	55	0	3	3	24	.256	.334	.462	.796	92	8.6	.335	109	7.9
17	Chase Headley C. Headley	31	2012	SDP	161	604	95	173	31	2	115	86	4	157	17	6	699	301	64	0	5	2	7	.286	.376	.498	.875	115	35.1	.378	146	38
18	Adrian Gonzalez A. Gonzalez	31	2010	SDP	160	591	87	176	33	0	101	93	2	114	0	0	692	302	64	2	4	35	15	.298	.393	.511	.904	112	32.3	.379	143	35.3
19	Phil Nevin P. Nevin	31	2000	SDP	143	538	87	163	34	1	107	59	4	121	2	0	605	292	66	0	4	9	17	.303	.374	.543	.916	104	24.4	.387	133	27.1
20	Fred McGriff F. McGriff	31	1991	SDP	153	528	84	147	19	1	106	105	2	135	4	1	642	261	51	0	7	26	14	.278	.396	.494	.890	105	32.9	.385	144	31.8
21	Manny Machado M. Machado	30	2023	SDP	138	543	75	140	21	0	91	50	2	109	3	2	601	251	51	0	6	1	20	.258	.319	.462	.782	81	7.7	.334	113	9.4
22	Wil Myers W. Myers	30	2017	SDP	155	567	80	138	29	3	74	70	5	180	20	6	649	263	62	0	7	3	15	.243	.328	.464	.792	87	7.8	.335	107	5.8
23	Adrian Gonzalez A. Gonzalez	30	2007	SDP	161	646	101	182	46	3	100	65	3	140	0	0	720	324	79	0	6	9	6	.282	.347	.502	.849	107	18.1	.361	123	21.7
24	Ryan Klesko R. Klesko	30	2001	SDP	146	538	105	154	34	6	113	88	3	89	23	4	638	290	70	0	9	7	16	.286	.384	.539	.923	112	32.8	.388	141	34.1
25	Steve Finley S. Finley	30	1996	SDP	161	655	126	195	45	9	95	56	4	87	22	8	721	348	84	1	5	5	20	.298	.354	.531	.885	118	25.4	.377	136	32.7