Between the 2006 and 2021 seasons, Albert Pujols smashed the most home runs, with 478 homers.

Interpreted as:

most home runs by a player from 2006 to 2021

	NAME	HR	G	AB	R	H	2B	3B	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS	WRC	WRAA	WOBA	WRC+	BRAA
1	Albert Pujols A. Pujols	478	2,181	8,160	1,243	2,319	445	5	1,529	944	69	1,005	87	26	9,262	4,208	928	0	89	245	319	.284	.360	.516	.875	1453	364	.367	132	362.3
2	Nelson Cruz N. Cruz	449	1,874	6,905	1,030	1,912	350	14	1,238	681	80	1,751	79	32	7,724	3,637	813	2	56	76	161	.277	.346	.527	.873	1228	324	.369	132	297.2
3	Miguel Cabrera M. Cabrera	424	2,182	8,095	1,259	2,528	502	11	1,514	1,042	59	1,573	33	17	9,277	4,324	937	1	80	215	290	.312	.391	.534	.925	1625	533.3	.391	145	495.6
4	Edwin Encarnacion E. Encarnacion	415	1,891	6,829	1,074	1,783	354	10	1,230	883	102	1,366	58	14	7,880	3,402	779	0	66	52	177	.261	.351	.498	.849	1206	281.2	.364	126	238
5	David Ortiz D. Ortiz	364	1,516	5,532	912	1,595	398	10	1,142	898	23	1,071	12	7	6,507	3,105	772	1	53	171	167	.288	.387	.561	.948	1164	406.3	.398	145	353.3
6	Ryan Howard R. Howard	358	1,465	5,356	791	1,374	255	19	1,126	674	57	1,730	12	4	6,140	2,741	632	0	53	146	108	.257	.343	.512	.855	911	193.5	.359	121	159.8
7	Ryan Braun R. Braun	352	1,766	6,622	1,080	1,963	408	49	1,154	586	77	1,363	216	60	7,329	3,525	809	0	44	56	179	.296	.358	.532	.891	1210	352.7	.379	135	310.8
8	Giancarlo Stanton G. Stanton	347	1,324	4,839	762	1,299	265	11	893	647	49	1,559	42	15	5,568	2,627	623	0	33	81	117	.268	.358	.543	.901	932	289	.380	142	279.1
9	Jose Bautista J. Bautista	344	1,723	5,935	1,013	1,474	308	17	972	1,022	80	1,347	69	31	7,117	2,848	669	22	58	58	167	.248	.363	.480	.843	1081	252.6	.365	127	223.3
10	Curtis Granderson C. Granderson	336	2,001	7,049	1,197	1,750	339	91	917	911	67	1,865	152	49	8,104	3,279	766	28	49	31	61	.248	.338	.465	.803	1122	170.9	.347	115	145.6
11	Joey Votto J. Votto	331	1,900	6,722	1,114	2,027	435	21	1,065	1,294	64	1,481	80	29	8,128	3,497	787	0	48	147	158	.302	.416	.520	.937	1489	538.2	.400	149	476.6
12	Justin Upton J. Upton	324	1,828	6,673	1,056	1,748	349	38	1,000	779	75	1,948	151	59	7,589	3,145	711	3	59	49	141	.262	.343	.471	.814	1079	197.7	.350	118	159.1
13	Robinson Cano R. Cano	320	2,102	8,151	1,179	2,469	537	29	1,240	600	82	1,121	50	35	8,895	4,024	886	3	59	111	268	.303	.354	.494	.848	1341	299.5	.362	127	281.4
14	Jay Bruce J. Bruce	319	1,650	5,964	839	1,455	312	32	951	600	28	1,572	65	40	6,641	2,788	663	3	46	71	101	.244	.314	.467	.781	847	79.1	.332	106	47.7
15	Evan Longoria E. Longoria	317	1,823	6,829	961	1,818	409	26	1,089	680	70	1,540	58	19	7,671	3,230	752	1	91	85	192	.266	.335	.473	.808	1053	160.6	.344	118	167.5
16	Prince Fielder P. Fielder	317	1,572	5,762	860	1,628	317	10	1,018	845	124	1,138	18	11	6,791	2,916	644	0	60	164	158	.283	.382	.506	.888	1104	311.9	.378	134	275.5
17	Adrian Beltre A. Beltre	311	1,811	7,003	999	2,063	424	19	1,110	524	65	1,034	56	15	7,662	3,458	754	1	69	74	189	.295	.346	.494	.840	1131	237.7	.359	121	187.8
18	Mike Trout M. Trout	310	1,288	4,656	967	1,419	268	49	816	865	86	1,215	203	37	5,659	2,715	627	0	52	109	58	.305	.419	.583	1.002	1134	478.3	.419	172	481.2
19	Adrian Gonzalez A. Gonzalez	310	1,870	6,947	973	2,006	427	11	1,178	770	45	1,358	6	7	7,837	3,385	748	4	71	156	204	.289	.360	.487	.847	1168	255.6	.361	128	264.1
20	Adam Dunn A. Dunn	304	1,340	4,612	677	1,067	207	4	794	855	46	1,646	22	9	5,545	2,194	515	1	31	74	70	.231	.355	.476	.831	815	167.3	.359	119	129.2
21	Mark Teixeira M. Teixeira	302	1,409	5,218	820	1,378	304	8	958	734	76	1,080	17	4	6,085	2,604	614	0	57	69	120	.264	.360	.499	.859	943	230	.368	126	194.4
22	Mark Reynolds M. Reynolds	298	1,688	5,432	794	1,283	253	14	871	707	56	1,927	64	31	6,243	2,458	565	3	45	26	117	.236	.328	.453	.780	821	94.7	.338	103	24.8
23	Chris Davis C. Davis	295	1,417	4,978	707	1,160	228	5	780	555	58	1,852	19	11	5,630	2,283	528	1	38	50	62	.233	.315	.459	.774	713	61.5	.332	106	31.8
24	Matt Kemp M. Kemp	287	1,750	6,365	950	1,808	338	37	1,031	518	26	1,641	184	63	6,982	3,081	662	1	72	69	184	.284	.337	.484	.821	985	172.6	.350	120	164.4
25	Ryan Zimmerman R. Zimmerman	284	1,779	6,596	957	1,823	407	22	1,055	643	31	1,372	43	16	7,339	3,126	713	1	68	43	211	.276	.340	.474	.814	1033	168.6	.349	115	135.8