5 players are tied for the most home runs in a game in the 1st inning, with 2 homers. The first three are David Ortiz on August 12, 2008, Aaron Boone on August 9, 2002 and Bret Boone on May 2, 2002.
Interpreted as:
most home runs by a player in the first inning in one regular-season game| NAME | HR | DATE | TM | OPP | AB | H | 2B | 3B | RBI | BB | HBP | SO | PA | TB | XBH | SH | SF | IBB | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | D. Ortiz | 2 | 8/12/2008 |  BOS | vs |  TEX | 2 | 2 | 0 | 0 | 6 | 0 | 0 | 0 | 2 | 8 | 2 | 0 | 0 | 0 |
| 2 |  | A. Boone | 2 | 8/9/2002 |  CIN | vs |  SDP | 2 | 2 | 0 | 0 | 4 | 0 | 0 | 0 | 2 | 8 | 2 | 0 | 0 | 0 |
| 3 | | B. Boone | 2 | 5/2/2002 |  SEA | @ |  CWS | 2 | 2 | 0 | 0 | 4 | 0 | 0 | 0 | 2 | 8 | 2 | 0 | 0 | 0 |
| 4 | | M. Cameron | 2 | 5/2/2002 | SEA | @ | CWS | 2 | 2 | 0 | 0 | 2 | 0 | 0 | 0 | 2 | 8 | 2 | 0 | 0 | 0 |
| 5 | | V. Hayes | 2 | 6/11/1985 |  PHI | vs |  NYM | 2 | 2 | 0 | 0 | 5 | 0 | 0 | 0 | 2 | 8 | 2 | 0 | 0 | 0 |
| 6 | | D. Schneider | 1 | 7/2/2025 |  TOR | vs |  NYY | 1 | 1 | 0 | 0 | 2 | 0 | 0 | 0 | 1 | 4 | 1 | 0 | 0 | 0 |
| 7 | | A. Barger | 1 | 7/2/2025 | TOR | vs | NYY | 1 | 1 | 0 | 0 | 3 | 0 | 0 | 0 | 1 | 4 | 1 | 0 | 0 | 0 |
| 8 | | S. Frelick | 1 | 7/2/2025 |  MIL | @ | NYM | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 4 | 1 | 0 | 0 | 0 |
| 9 |  | B. Rooker | 1 | 7/2/2025 |  ATH | @ |  TBR | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 4 | 1 | 0 | 0 | 0 |
| 10 | | J. Rogers | 1 | 7/2/2025 |  DET | @ |  WSH | 1 | 1 | 0 | 0 | 3 | 0 | 0 | 0 | 1 | 4 | 1 | 0 | 0 | 0 |
| 11 |  | R. Greene | 1 | 7/2/2025 | DET | @ | WSH | 1 | 1 | 0 | 0 | 3 | 0 | 0 | 0 | 1 | 4 | 1 | 0 | 0 | 0 |
| 12 | | M. Yastrzemski | 1 | 7/2/2025 |  SFG | @ |  AZ | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 4 | 1 | 0 | 0 | 0 |
| 13 |  | W. Smith | 1 | 7/2/2025 |  LAD | vs | CWS | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 4 | 1 | 0 | 0 | 0 |
| 14 | | H. Goodman | 1 | 7/1/2025 |  COL | vs |  HOU | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 4 | 1 | 0 | 0 | 0 |
| 15 | | S. Horwitz | 1 | 6/30/2025 |  PIT | vs |  STL | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 4 | 1 | 0 | 0 | 0 |
| 16 | | S. Langeliers | 1 | 6/30/2025 | ATH | @ | TBR | 1 | 1 | 0 | 0 | 3 | 0 | 0 | 0 | 1 | 4 | 1 | 0 | 0 | 0 |
| 17 |  | T. Story | 1 | 6/30/2025 | BOS | vs | CIN | 1 | 1 | 0 | 0 | 3 | 0 | 0 | 0 | 1 | 4 | 1 | 0 | 0 | 0 |
| 18 |  | T. Pham | 1 | 6/29/2025 | PIT | vs | NYM | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 4 | 1 | 0 | 0 | 0 |
| 19 |  | O. Cruz | 1 | 6/29/2025 | PIT | vs | NYM | 1 | 1 | 0 | 0 | 2 | 0 | 0 | 0 | 1 | 4 | 1 | 0 | 0 | 0 |
| 20 | | K. Carpenter | 1 | 6/29/2025 | DET | vs |  MIN | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 4 | 1 | 0 | 0 | 0 |
| 21 | | A. Barger | 1 | 6/29/2025 | TOR | @ | BOS | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 4 | 1 | 0 | 0 | 0 |
| 22 |  | V. Guerrero Jr. | 1 | 6/29/2025 | TOR | @ | BOS | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 4 | 1 | 0 | 0 | 0 |
| 23 | | N. Gorman | 1 | 6/29/2025 | STL | @ |  CLE | 1 | 1 | 0 | 0 | 3 | 0 | 0 | 0 | 1 | 4 | 1 | 0 | 0 | 0 |
| 24 |  | J. Aranda | 1 | 6/28/2025 | TBR | @ |  BAL | 1 | 1 | 0 | 0 | 2 | 0 | 0 | 0 | 1 | 4 | 1 | 0 | 0 | 0 |
| 25 |  | W. Abreu | 1 | 6/28/2025 | BOS | vs | TOR | 1 | 1 | 0 | 0 | 3 | 0 | 0 | 0 | 1 | 4 | 1 | 0 | 0 | 0 |
Results may be incomplete. StatMuse has complete event-level data for home runs going back to the 1974 season.
Some of the information used here was obtained free of charge from Retrosheet.
Phillies 
Cubs 
Padres 
MIA 
LAA 
