Since 2000, David Ortiz has crushed the most homers by a designated hitter, with 531 homers.

	NAME	HR	G	AB	R	H	2B	3B	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS	wRC	WRAA	wOBA	wRC+	BRAA
1	David Ortiz D. Ortiz	531	2,297	8,293	1,361	2,379	609	19	1,716	1,273	33	1,647	16	9	9,689	4,619	1,159	2	88	206	225	.287	.380	.557	.937	1706	556	.394	141	483.8
2	Shohei Ohtani S. Ohtani	280	1,018	3,730	708	1,050	192	45	669	541	25	1,104	165	43	4,316	2,172	517	0	20	88	49	.282	.374	.582	.957	807	292.3	.397	156	288.6
3	Nelson Cruz N. Cruz	263	1,099	4,020	596	1,101	179	6	743	429	64	1,041	16	7	4,551	2,081	448	0	38	50	116	.274	.350	.518	.868	727	188.9	.366	135	191.8
4	Edwin Encarnacion E. Encarnacion	220	929	3,365	545	878	166	2	636	474	45	726	31	7	3,925	1,708	388	0	41	29	94	.261	.356	.508	.864	619	161.2	.367	131	141.8
5	Frank Thomas F. Thomas	220	951	3,307	526	904	178	2	664	591	46	656	4	5	3,983	1,746	400	0	39	35	74	.273	.387	.528	.915	697	202.3	.391	136	186
6	Travis Hafner T. Hafner	213	1,183	4,058	619	1,107	250	13	731	598	90	976	11	7	4,775	2,022	476	0	29	81	86	.273	.376	.498	.874	766	193.9	.374	132	189.5
7	Giancarlo Stanton G. Stanton	183	722	2,638	359	642	108	1	484	306	18	895	6	1	2,982	1,301	292	0	20	17	84	.243	.324	.493	.817	435	81.4	.347	124	84.4
8	Jim Thome J. Thome	182	805	2,503	432	663	127	2	506	490	19	786	1	1	3,032	1,340	311	0	20	46	59	.265	.387	.535	.922	530	165.9	.393	139	145.9
9	J.D. Martinez	179	870	3,324	506	936	222	11	595	353	26	928	10	1	3,738	1,717	412	0	35	31	110	.282	.352	.517	.868	605	156.4	.365	130	137.6
10	Yordan Alvarez Y. Alvarez	170	677	2,455	429	728	156	6	493	346	40	566	9	2	2,867	1,406	332	0	26	42	60	.297	.389	.573	.961	549	206.4	.402	163	212.4
11	Kendrys Morales K. Morales	154	980	3,550	413	933	185	3	536	306	35	748	2	4	3,916	1,586	342	0	25	23	125	.263	.325	.447	.772	502	53.8	.332	110	46.8
12	Marcell Ozuna M. Ozuna	141	635	2,321	335	624	112	1	384	294	11	630	3	1	2,644	1,161	254	0	18	8	58	.269	.351	.500	.852	425	110.6	.364	131	102.3
13	Victor Martinez V. Martinez	115	969	3,558	405	1,033	188	0	540	319	25	409	4	4	3,942	1,566	303	0	40	67	131	.290	.349	.440	.789	521	73.7	.339	113	56.4
14	Jorge Soler J. Soler	113	484	1,735	273	435	99	2	280	226	25	520	5	1	1,999	877	214	0	13	7	48	.251	.343	.505	.849	314	69.9	.358	125	63.6
15	Billy Butler B. Butler	111	1,097	3,902	437	1,107	226	4	557	373	27	659	4	3	4,336	1,674	341	0	34	48	155	.284	.348	.429	.777	564	70.5	.337	110	52
16	Edgar Martinez E. Martinez	111	668	2,337	339	689	142	1	481	406	29	456	9	3	2,805	1,166	254	0	33	42	62	.295	.401	.499	.900	481	130.8	.386	138	137.6
17	Adam Dunn A. Dunn	108	553	1,908	232	385	68	0	288	327	15	747	4	4	2,263	777	176	0	13	15	25	.202	.321	.407	.728	266	15.1	.322	101	0.9
18	Brent Rooker B. Rooker	99	444	1,635	235	438	86	6	270	173	20	504	21	4	1,838	833	191	0	10	9	29	.268	.343	.509	.853	292	73.8	.363	138	82.1
19	Albert Pujols A. Pujols	95	509	1,884	215	486	69	0	352	154	19	278	9	3	2,080	840	164	0	23	20	81	.258	.317	.446	.763	256	12.9	.325	107	15.5
20	Kyle Schwarber K. Schwarber	94	314	1,181	221	287	45	2	236	215	16	396	15	5	1,421	618	141	0	9	10	10	.243	.365	.523	.888	243	76.3	.378	144	74.2
21	Brad Fullmer B. Fullmer	89	548	1,897	295	532	123	12	314	153	32	261	24	12	2,101	946	224	0	19	22	45	.280	.341	.499	.840	307	44.5	.356	113	33.7
22	Evan Gattis E. Gattis	84	409	1,420	173	343	56	11	238	106	10	347	3	2	1,554	673	151	0	18	11	38	.242	.295	.474	.769	191	11.4	.324	107	13.5
23	Jonny Gomes J. Gomes	84	514	1,543	232	370	70	10	231	195	43	517	33	16	1,803	712	164	2	20	7	20	.240	.338	.461	.799	246	27.2	.345	113	26.8
24	Dmitri Young D. Young	82	487	1,793	255	500	100	13	267	143	28	379	6	3	1,975	872	195	0	11	32	55	.279	.340	.486	.826	278	36.5	.350	115	36.7
25	Khris Davis K. Davis	76	356	1,244	179	286	49	2	216	126	18	378	0	0	1,400	567	127	0	12	8	34	.230	.307	.456	.763	176	5.9	.323	106	9.7