Carlos Pena has hit the most career homers against Andy Pettitte, with 6 home runs.

Interpreted as:

most home runs by a player vs Andy Pettitte

	NAME	HR	G	AB	H	2B	3B	RBI	BB	HBP	SO	PA	TB	XBH	SH	SF	IBB	AVG	OBP	SLG	OPS
1	Carlos Pena C. Pena	6	17	46	16	0	3	12	4	3	15	53	40	9	0	0	0	.348	.434	.870	1.304
2	Carlos Delgado C. Delgado	5	25	66	21	3	0	17	10	0	18	77	39	8	0	1	0	.318	.403	.591	.994
3	Alex Rodriguez A. Rodriguez	5	13	42	9	0	0	9	3	0	5	45	24	5	0	0	1	.214	.267	.571	.838
4	Rafael Palmeiro R. Palmeiro	4	19	58	19	0	0	15	0	1	3	61	31	4	0	2	0	.328	.328	.534	.862
5	Herbert Perry H. Perry	4	12	33	13	2	0	5	2	1	6	36	27	6	0	0	0	.394	.444	.818	1.263
6	Manny Ramirez M. Ramirez	4	29	79	32	8	0	20	8	1	7	89	52	12	0	1	2	.405	.461	.658	1.119
7	Jose Canseco J. Canseco	4	15	40	13	3	0	13	5	0	8	45	28	7	0	0	0	.325	.400	.700	1.100
8	Jose Bautista J. Bautista	3	12	31	10	1	1	7	5	0	3	36	22	5	0	0	0	.323	.417	.710	1.126
9	J.D. Drew	3	15	42	15	3	0	4	1	0	13	43	27	6	0	0	0	.357	.372	.643	1.015
10	Jhonny Peralta J. Peralta	3	6	16	6	1	1	9	2	0	0	18	18	5	0	0	0	.375	.444	1.125	1.569
11	Reggie Sanders R. Sanders	3	4	10	4	0	0	4	1	0	3	11	13	3	0	0	0	.400	.455	1.300	1.755
12	Scott Rolen S. Rolen	3	15	38	12	4	0	6	3	0	8	41	25	7	0	0	1	.316	.366	.658	1.024
13	Troy Glaus T. Glaus	3	13	37	10	4	0	6	7	0	11	44	23	7	0	0	1	.270	.386	.622	1.008
14	Randy Velarde R. Velarde	3	7	19	7	1	0	3	5	0	2	24	17	4	0	0	0	.368	.500	.895	1.395
15	Ed Sprague E. Sprague	3	11	31	7	2	0	7	4	0	8	35	18	5	0	0	0	.226	.314	.581	.895
16	Garret Anderson G. Anderson	3	25	82	33	3	0	10	1	0	11	83	45	6	0	0	0	.402	.410	.549	.958
17	Ken Griffey Jr. K. Griffey Jr.	3	21	59	21	3	0	9	7	0	8	66	33	6	0	0	0	.356	.424	.559	.984
18	Frank Thomas F. Thomas	3	20	51	19	4	0	15	11	0	6	62	32	7	0	0	1	.373	.484	.627	1.111
19	Evan Longoria E. Longoria	2	10	23	3	1	0	4	4	1	11	29	10	3	0	1	0	.130	.276	.435	.711
20	Billy Butler B. Butler	2	7	18	5	2	0	2	3	0	4	21	13	4	0	0	0	.278	.381	.722	1.103
21	Nick Markakis N. Markakis	2	15	44	12	2	0	4	1	0	6	45	20	4	0	0	0	.273	.289	.455	.743
22	Ben Zobrist B. Zobrist	2	10	25	10	1	0	7	3	0	3	29	17	3	0	1	0	.400	.448	.680	1.128
23	Dioner Navarro D. Navarro	2	9	19	5	0	0	4	1	0	3	22	11	2	2	0	0	.263	.300	.579	.879
24	Miguel Cabrera M. Cabrera	2	5	14	5	2	0	3	1	0	3	15	13	4	0	0	0	.357	.400	.929	1.329
25	Rich Aurilia R. Aurilia	2	7	21	8	1	1	4	1	0	2	22	17	4	0	0	0	.381	.409	.810	1.219

Unlock 2x data

StatMuse has event-level data for home runs going back to the 1974 season.

Some of the information used here was obtained free of charge from Retrosheet.

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Thu 3/26	TBR	@	STL	4:15 PM
Sat 3/28	TBR	@	STL	2:15 PM
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Tue 9/16	TOR	@	TBR	1-2
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Wed 3/25	NYY	@	SFG	8:05 PM
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Carlos Pena has hit the most career homers against Andy Pettitte, with 6 home runs.

Interpreted as:

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