Between the 1915 and 1927 seasons, Babe Ruth hit the most homers, with 416 home runs.

	NAME	HR	G	AB	R	H	2B	3B	RBI	BB	HBP	SO	SB	PA	TB	XBH	SH	AVG	OBP	SLG	OPS	WRC	WRAA	WOBA	WRC+	BRAA
1	Babe Ruth B. Ruth	416	1,496	4,949	1,282	1,729	340	98	1,262	1,221	29	828	92	6,270	3,513	854	71	.349	.481	.710	1.190	1645	905.7	.527	204	849.8
2	Cy Williams C. Williams	230	1,684	6,148	949	1,824	287	68	907	586	78	622	106	6,959	2,937	585	147	.297	.365	.478	.843	1096	299.2	.392	125	206.4
3	Rogers Hornsby R. Hornsby	217	1,689	6,366	1,213	2,288	393	152	1,176	734	40	512	126	7,301	3,636	762	161	.359	.429	.571	1.000	1525	682.2	.457	175	665.3
4	Ken Williams K. Williams	185	1,190	4,261	780	1,364	246	74	828	514	27	265	149	4,940	2,313	505	138	.320	.397	.543	.940	926	329	.427	137	247.9
5	Harry Heilmann H. Heilmann	133	1,646	6,104	1,015	2,119	410	127	1,198	663	35	385	98	7,020	3,182	670	218	.347	.414	.521	.935	1331	517.1	.432	148	438.9
6	Jack Fournier J. Fournier	129	1,318	4,584	752	1,459	225	97	790	531	81	341	125	5,327	2,265	451	131	.318	.399	.494	.893	931	297.6	.413	144	289.2
7	High Pockets Kelly H. Pockets Kelly	128	1,205	4,458	637	1,332	234	57	783	289	24	535	55	4,874	2,064	419	103	.299	.345	.463	.808	695	101.1	.370	116	99.4
8	Bob Meusel B. Meusel	125	1,063	4,123	641	1,309	278	79	839	293	18	458	126	4,554	2,120	482	120	.317	.365	.514	.880	751	188.2	.398	123	144.4
9	Tilly Walker T. Walker	110	1,113	3,999	556	1,115	208	49	542	340	23	423	72	4,483	1,751	367	121	.279	.339	.438	.777	609	117.7	.365	113	67.6
10	Irish Meusel I. Meusel	106	1,288	4,898	701	1,521	250	93	819	269	17	199	113	5,307	2,275	449	123	.311	.349	.464	.813	766	136	.374	117	111
11	Zack Wheat Z. Wheat	101	1,682	6,343	941	2,059	325	115	901	457	53	286	112	6,945	2,917	541	92	.325	.375	.460	.835	1078	284	.389	132	260.1
12	George Sisler G. Sisler	93	1,647	6,667	1,091	2,295	343	145	962	385	40	278	351	7,269	3,207	581	177	.344	.384	.481	.865	1188	356.9	.402	129	252
13	Wally Pipp W. Pipp	88	1,765	6,611	941	1,859	300	142	973	571	36	532	124	7,479	2,707	530	261	.281	.342	.409	.751	952	102.7	.354	105	39.4
14	Jim Bottomley J. Bottomley	86	767	2,998	480	991	188	72	612	265	20	229	27	3,375	1,581	346	92	.331	.389	.527	.916	604	185	.416	139	168.8
15	Lou Gehrig L. Gehrig	84	459	1,631	365	543	127	49	363	263	6	214	22	1,952	1,020	260	52	.333	.427	.625	1.053	431	188.9	.469	166	174.1
16	Baby Doll Jacobson B. Doll Jacobson	83	1,472	5,507	787	1,714	328	94	818	355	39	410	86	6,072	2,479	505	171	.311	.357	.450	.807	879	160.8	.374	109	69.8
17	Tristram Speaker T. Speaker	75	1,810	6,616	1,258	2,312	554	126	1,028	993	53	168	193	7,877	3,343	755	215	.349	.438	.505	.944	1517	622	.440	154	526.2
18	Goose Goslin G. Goslin	73	864	3,337	555	1,104	176	93	629	305	34	229	82	3,766	1,685	342	90	.331	.393	.505	.897	656	188.2	.410	132	164
19	Elmer Smith E. Smith	70	999	3,142	464	864	178	62	532	317	16	348	53	3,573	1,376	310	98	.275	.344	.438	.782	492	92.9	.366	111	50.2
20	Bing Miller B. Miller	69	892	3,240	511	1,033	198	52	509	170	49	208	63	3,600	1,542	319	141	.319	.362	.476	.838	549	101.5	.383	111	52.4
21	Gavvy Cravath G. Cravath	68	677	2,158	308	602	131	41	378	318	15	302	41	2,541	1,019	240	50	.279	.375	.472	.848	407	155.3	.407	153	136.7
22	Hack Wilson H. Wilson	67	460	1,653	306	503	92	36	325	205	14	211	32	1,909	868	195	37	.304	.386	.525	.911	337	102.1	.414	142	100.5
23	Ty Cobb T. Cobb	67	1,698	6,391	1,313	2,348	427	155	1,085	814	43	288	403	7,421	3,286	649	173	.367	.442	.514	.956	1453	611	.446	160	531
24	Al Simmons A. Simmons	66	558	2,237	367	794	163	42	449	144	5	180	44	2,440	1,239	271	54	.355	.395	.554	.949	463	159	.429	137	122.9
25	Gabby Hartnett G. Hartnett	66	564	1,788	240	507	115	21	298	182	15	223	18	2,029	862	202	44	.284	.355	.482	.837	307	54.6	.381	118	46.3