Between the 2000 and 2009 seasons, Carlos Delgado launched the most homers by a first baseman, with 324 home runs.

	NAME	HR	G	AB	R	H	2B	3B	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS	WRC	WRAA	WOBA	WRC+	BRAA
1	Carlos Delgado C. Delgado	324	1,368	4,951	863	1,416	326	12	1,045	796	126	1,121	9	3	5,938	2,738	662	0	65	151	108	.286	.394	.553	.947	1069	335.2	.397	141	309.5
2	Paul Konerko P. Konerko	295	1,477	5,357	790	1,491	274	3	935	599	71	874	7	1	6,082	2,656	572	0	55	50	194	.278	.355	.496	.851	926	176.8	.364	118	138.4
3	Derrek Lee D. Lee	270	1,448	5,254	854	1,536	339	26	841	695	52	1,164	94	41	6,048	2,737	635	2	45	67	146	.292	.378	.521	.899	1017	274.1	.383	131	239.9
4	Todd Helton T. Helton	260	1,466	5,305	1,017	1,756	431	27	981	1,001	39	741	26	17	6,409	3,021	718	2	62	164	130	.331	.436	.569	1.006	1299	508.8	.424	144	366.3
5	Albert Pujols A. Pujols	252	924	3,375	704	1,126	249	7	731	591	41	343	53	22	4,046	2,145	508	0	39	167	126	.334	.435	.636	1.070	871	377.1	.441	172	369.7
6	Jason Giambi J. Giambi	252	1,083	3,557	652	998	191	5	760	792	114	793	10	5	4,505	1,955	448	0	42	55	77	.281	.423	.550	.972	880	326	.415	156	319.4
7	Mark Teixeira M. Teixeira	242	1,060	4,023	669	1,167	266	16	798	523	65	808	15	3	4,638	2,191	524	0	27	69	92	.290	.378	.545	.923	806	239.3	.391	135	202.6
8	Richie Sexson R. Sexson	234	1,031	3,727	558	961	199	8	701	489	38	993	8	9	4,278	1,878	441	0	24	29	109	.258	.348	.504	.852	651	126.9	.364	122	117.9
9	Jim Thome J. Thome	234	822	2,842	542	782	143	8	614	611	21	880	2	8	3,499	1,643	385	0	25	77	42	.275	.404	.578	.982	672	237	.410	149	220
10	Ryan Howard R. Howard	222	732	2,687	465	750	136	11	640	406	25	878	10	3	3,145	1,574	369	0	27	105	50	.279	.376	.586	.961	561	177	.396	138	154.4
11	Carlos Pena C. Pena	202	929	3,136	495	776	153	20	566	495	47	973	18	13	3,713	1,575	375	4	31	33	47	.247	.355	.502	.858	571	119.1	.367	126	119.6
12	Jeff Bagwell J. Bagwell	186	833	3,038	596	867	174	11	568	516	46	652	44	20	3,631	1,621	371	0	31	34	94	.285	.394	.534	.927	651	200	.395	135	167.1
13	Rafael Palmeiro R. Palmeiro	170	737	2,630	414	716	138	3	496	437	24	365	9	3	3,128	1,370	311	0	37	60	56	.272	.376	.521	.897	516	127.3	.378	127	106.8
14	Prince Fielder P. Fielder	160	675	2,380	382	675	139	8	453	345	47	535	14	9	2,804	1,310	307	0	32	66	52	.284	.381	.550	.931	485	142.5	.391	137	131.1
15	Justin Morneau J. Morneau	159	827	3,083	464	869	186	13	607	337	22	503	4	7	3,486	1,558	358	0	44	64	75	.282	.352	.505	.858	520	94.7	.362	121	90.8
16	Lance Berkman L. Berkman	157	732	2,579	453	761	164	8	506	479	24	509	39	14	3,106	1,412	329	0	24	77	66	.295	.407	.547	.954	571	191.8	.403	146	180.4
17	Adam LaRoche A. LaRoche	136	838	2,877	402	787	205	7	469	306	12	688	4	8	3,230	1,414	348	5	30	37	72	.274	.343	.491	.834	464	69.3	.355	114	56
18	Adrian Gonzalez A. Gonzalez	131	655	2,426	384	690	146	7	407	312	18	510	1	2	2,776	1,243	284	2	18	58	77	.284	.368	.512	.880	440	100.1	.373	133	114.4
19	Tino Martinez T. Martinez	126	866	2,906	393	769	140	10	473	309	33	431	14	7	3,276	1,307	276	3	25	39	74	.265	.339	.450	.789	431	24.4	.339	105	18.5
20	Kevin Millar K. Millar	125	1,050	3,448	479	908	199	6	490	444	61	630	6	7	3,988	1,494	330	0	35	13	87	.263	.354	.433	.788	544	53.3	.346	107	34.9
21	Tony Clark T. Clark	121	865	2,186	288	551	115	7	398	239	8	592	0	1	2,453	1,043	243	0	20	28	75	.252	.325	.477	.802	326	23.5	.340	103	11.3
22	Ryan Klesko R. Klesko	112	674	2,331	381	650	151	12	411	366	12	407	59	19	2,738	1,161	275	2	27	34	58	.279	.376	.498	.874	440	99.8	.374	129	104.7
23	Mike Sweeney M. Sweeney	104	538	2,059	339	654	130	1	408	229	29	221	30	15	2,346	1,098	235	1	28	37	44	.318	.389	.533	.922	412	117.6	.391	131	91.9
24	Lyle Overbay L. Overbay	102	972	3,343	448	934	250	8	456	444	12	678	12	6	3,826	1,506	360	2	25	44	99	.279	.363	.450	.814	544	75.7	.353	112	56.3
25	Fred McGriff F. McGriff	101	536	1,899	248	531	84	4	351	251	8	391	4	4	2,174	926	189	0	16	33	49	.280	.363	.488	.851	331	59.5	.363	119	53.1