Barry Bonds has hit the most career home runs against left-handed pitchers, with 227 homers.

Interpreted as:

most hr by a player vs left hand pitchers ever

	NAME	HR	G	AB	H	2B	3B	RBI	BB	HBP	SO	PA	TB	XBH	SH	SF	IBB	AVG	OBP	SLG	OPS
1	Barry Bonds B. Bonds	227	1,925	3,351	968	201	29	660	706	54	575	4,147	1,908	457	2	34	111	.289	.417	.569	.986
2	Albert Pujols A. Pujols	200	1,461	2,981	896	206	4	568	390	17	339	3,423	1,710	410	0	35	105	.301	.381	.574	.954
3	Ken Griffey Jr. K. Griffey Jr.	186	1,665	3,091	830	149	9	558	319	39	646	3,488	1,555	344	5	34	20	.269	.341	.503	.844
4	Dave Winfield D. Winfield	183	1,532	3,356	992	173	31	584	503	4	434	3,893	1,776	387	2	28	102	.296	.385	.529	.914
5	Alex Rodriguez A. Rodriguez	172	1,314	2,672	761	150	12	502	427	24	560	3,151	1,451	334	0	28	57	.285	.385	.543	.928
6	Frank Thomas F. Thomas	160	1,013	1,955	630	125	3	422	453	12	313	2,445	1,241	288	0	25	63	.322	.448	.635	1.083
7	Rafael Palmeiro R. Palmeiro	160	1,636	3,142	872	154	11	574	306	28	427	3,526	1,528	325	13	37	10	.278	.343	.486	.830
8	Mark McGwire M. McGwire	156	830	1,595	424	75	1	378	399	12	373	2,032	969	232	0	26	69	.266	.411	.608	1.018
9	Sammy Sosa S. Sosa	151	1,088	2,247	665	112	12	409	349	4	585	2,620	1,254	275	5	15	81	.296	.389	.558	.947
10	Matt Williams M. Williams	147	932	1,982	565	92	8	396	171	7	335	2,181	1,114	247	4	17	51	.285	.341	.562	.903
11	Eddie Murray E. Murray	142	1,693	3,708	1,022	185	8	576	375	9	442	4,133	1,649	335	0	41	59	.276	.340	.445	.785
12	Manny Ramirez M. Ramirez	141	1,079	2,088	699	161	3	463	404	21	357	2,537	1,289	305	0	24	101	.335	.443	.617	1.060
13	Nelson Cruz N. Cruz	138	1,044	2,093	612	111	7	362	278	23	485	2,417	1,151	256	0	19	57	.292	.378	.550	.928
14	Andre Dawson A. Dawson	137	1,207	2,733	810	144	25	432	184	17	376	2,967	1,415	306	2	31	63	.296	.341	.518	.859
15	Jose Canseco J. Canseco	136	823	1,740	486	83	6	380	249	15	467	2,024	989	225	0	20	31	.279	.371	.568	.939
16	Mike Schmidt M. Schmidt	133	967	1,909	572	111	16	367	378	15	336	2,323	1,114	260	3	18	80	.300	.416	.584	.999
17	Andres Galarraga A. Galarraga	132	1,067	2,299	700	139	7	442	194	20	501	2,539	1,249	278	0	26	48	.304	.360	.543	.903
18	Gary Sheffield G. Sheffield	131	1,062	2,259	693	108	8	438	370	17	233	2,671	1,210	247	4	21	41	.307	.405	.536	.941
19	Lance Parrish L. Parrish	130	1,089	2,521	687	104	16	373	252	5	445	2,808	1,213	250	6	24	32	.273	.337	.481	.818
20	Dave Kingman D. Kingman	130	817	1,741	429	69	5	326	209	10	469	1,983	898	204	3	20	43	.246	.327	.516	.843
21	Cal Ripken Jr. C. Ripken Jr.	128	1,500	3,261	929	192	11	444	357	14	304	3,675	1,527	331	4	39	54	.285	.354	.468	.822
22	Paul Konerko P. Konerko	127	1,060	2,185	647	124	3	398	263	13	325	2,479	1,158	254	1	17	31	.296	.372	.530	.902
23	Fred McGriff F. McGriff	126	1,506	2,811	744	108	14	487	335	15	672	3,185	1,258	248	2	22	9	.265	.344	.448	.791
24	Carlos Beltran C. Beltran	124	1,309	2,656	744	181	16	434	253	13	493	2,952	1,329	321	3	27	25	.280	.342	.500	.843
25	George Foster G. Foster	123	974	2,174	625	103	19	396	232	8	383	2,435	1,135	245	0	21	62	.287	.355	.522	.877